RESUMO
Trichinosis was experimentally induced in rats. The morphology of encystation of Trichinella larvae was studied in the striated muscles. The efficacy of albendazole was evaluated in different intensity of Trichinella larvae infestation in the striated muscles of the laboratory animals. Encystation was shown to cease at 21 days. Albendazole showed high activity against intestinal and encapsulated larvae of Trichinella, leading to 100% death of T. spiralis. Capsules and Trichinella larvae were described to be destructed after treatment with albendazole 15 mg/kg twice daily for 10 days.
Assuntos
Albendazol/farmacologia , Anti-Helmínticos/farmacologia , Músculo Esquelético , Trichinella spiralis , Triquinelose , Animais , Músculo Esquelético/parasitologia , Músculo Esquelético/patologia , Ratos , Triquinelose/tratamento farmacológico , Triquinelose/patologiaRESUMO
The authors propose a mathematical model that makes it possible to estimate the severity of experimental trichinosis from the peripheral blood values of a laboratory animal (white blood cells, neutrophils, eosinophils, and lymphocyates).