RESUMO
Duodenal dystrophy (DD) is the pathological change in the wall of the duodenum, which is caused by chronic inflammation in its ectopic pancreatic tissue. The most common complications of DD are acute or chronic pancreatitis and impaired duodenal patency, which along with severe pain are an indication for surgical treatment. Pancreaticoduodenal resection is recognized as the operation of choice. The paper describes a clinical case demonstrating the efficiency and safety of minimally invasive (laparoscopic) surgical technologies in this category of patients. Resectional interventions of this volume are also shown to be accompanied by the development of pancreatic insufficiency that necessitates continuous enzyme replacement therapy.
Assuntos
Duodenopatias , Duodeno/patologia , Insuficiência Pancreática Exócrina , Pâncreas/patologia , Pancreatectomia/métodos , Pancreatina/uso terapêutico , Pancreatite Crônica , Complicações Pós-Operatórias/tratamento farmacológico , Adulto , Atrofia , Coristoma/diagnóstico , Coristoma/fisiopatologia , Duodenopatias/complicações , Duodenopatias/diagnóstico , Duodenopatias/fisiopatologia , Terapia de Reposição de Enzimas , Insuficiência Pancreática Exócrina/tratamento farmacológico , Insuficiência Pancreática Exócrina/etiologia , Fármacos Gastrointestinais/uso terapêutico , Humanos , Laparoscopia/métodos , Masculino , Procedimentos Cirúrgicos Minimamente Invasivos/métodos , Pancreatite Crônica/diagnóstico , Pancreatite Crônica/etiologia , Pancreatite Crônica/fisiopatologia , Pancreatite Crônica/cirurgia , Resultado do TratamentoRESUMO
The paper describes a clinical case in a 56-year-old female patient who has been suffering from chronic autoimmune pancreatitis, chronic recurrent cholangitis for 3 years. It demonstrates diagnostic difficulties at the early stage of the disease, the specific features of its course, the sequence of treatment in the patient, and problems in choosing a therapy option to achieve a remission.
Assuntos
Doenças Autoimunes , Azatioprina/administração & dosagem , Colangite , Imunossupressores/administração & dosagem , Pancreatite Crônica , Doenças Autoimunes/diagnóstico , Doenças Autoimunes/tratamento farmacológico , Doenças Autoimunes/fisiopatologia , Colangite/diagnóstico , Colangite/tratamento farmacológico , Colangite/fisiopatologia , Feminino , Humanos , Pessoa de Meia-Idade , Pancreatite Crônica/diagnóstico , Pancreatite Crônica/tratamento farmacológico , Pancreatite Crônica/fisiopatologia , Resultado do TratamentoRESUMO
Before using MSC transplantation in the clinic to conduct preclinical studies MSCs to animals with acute and chronic pancreatitis. Work out the timing and dose of MSCs. The rationale of MSCs transplantation for the regeneration of damaged pancreatic tissue. The essence of the experiments is to establish the existence of common pathogenetic mechanisms for the development of pathological processes and sanogenesis toxic damage of pancreatic tissue. The study was work out in the rat model of acute and chronic pancreatitis, to explore beneficial and adverse effects of allogeneic stem cells for regenerative-reduction processes. For cell transplantation using allogenic stromal cell fraction of bone marrow, the cell suspension was injected at a dose of 2 x 10(6) and 5 x 10(6) cells.