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1.
PLoS One ; 14(5): e0217396, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31120980

RESUMO

BACKGROUND: Postcoital bleeding (PCB) is a common gynecological symptom that may cause concern among both patients and physicians. Current literature is inconclusive regarding management recommendations. OBJECTIVE: To identify risk-factors for dysplasia/cancer among patients presenting post-coital bleeding (PCB). METHODS: Using large health maintenance organization (HMO) database, all women reporting PCB in 2012-2015 were identified. PCB patient records in a single colposcopy center were reviewed. Age, marital status, ethnicity, gravidity, parity, BMI, smoking, PAP smear result (within 1 year of PCB presentation), colposcopy and biopsy results were recorded. Cases were matched by age and socio-economic enumeration area to controls accessing primary care clinics for routine care. RESULTS: Yearly incidence of PCB ranged from 400 to 900 per 100,000 women; highest among patients aged 26-30 years. Among the sample of 411 PCB cases with colposcopy, 201 (48.9%) had directed biopsy. Biopsy results included 68 cervicitis (33.8%), 61 koilocytosis/CIN 1/condyloma (30.3%), 44 normal tissue (21.9%), 25 cervical polyp (12.4%), 2 CIN 2/3 (1%) and 1 carcinoma (0.5%). Positive predictive value for koilocytosis/CIN 1 or higher pathology was 15.6% (64/411) and 0.7% for CIN 2 or higher grade pathology (3/411). In conditional logistic regression, multiparty was a protective factor: OR 0.39 (95% CI 0.22-0.88, P = 0.02), while pathological PAP smear was a related risk-factor: OR 3.3 (95% CI 1.31-8.35, P = 0.01). When compared to controls, PCB patients were significantly (P = 0.04) more likely to present CIN 1 or higher grade pathology (OR 1.82, 95% CI 1.02-3.33). CONCLUSIONS: Study results indicate that PCB may require colposcopy, especially for nulliparous women with an abnormal PAP smear.


Assuntos
Coito , Hemorragia/etiologia , Doenças do Colo do Útero/etiologia , Displasia do Colo do Útero/diagnóstico , Adolescente , Adulto , Estudos de Casos e Controles , Colposcopia , Feminino , Hemorragia/epidemiologia , Humanos , Incidência , Israel/epidemiologia , Pessoa de Meia-Idade , Teste de Papanicolaou , Paridade , Estudos Retrospectivos , Fatores de Risco , Doenças do Colo do Útero/diagnóstico , Doenças do Colo do Útero/epidemiologia , Displasia do Colo do Útero/epidemiologia , Neoplasias do Colo do Útero/diagnóstico , Neoplasias do Colo do Útero/epidemiologia , Esfregaço Vaginal , Adulto Jovem
2.
Gynecol Obstet Invest ; 84(1): 45-49, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30071512

RESUMO

STUDY OBJECTIVE: The study aimed to evaluate whether there is an association between the ovarian ligament length and ovarian torsion. DESIGN: This is a prospective cohort study. Design Classification: II.2. SETTING: The study was conducted in the gynecology department of a university affiliated hospital. INTERVENTION: We measured the length of the ovarian ligaments during laparoscopy. PATIENTS: A total of 56 women were recruited, of which 28 women were operated for ovarian torsion (torsion group) and 28 others for other gynecologic conditions (control group). MEASUREMENT AND MAIN RESULTS: The study found correlations between ovarian ligament length and ovarian torsion. The length of the right (2.2 ± 0.6 cm) and left ovarian ligament (2.3 ± 0.8 cm) in the control patients were similar. Ovarian torsions occurred mainly on the right side (67.9 %). The right ovarian ligament was significantly longer in the torsion group (3.2 ± 0.9 cm) than in the control group (2.2 ± 0.6 cm; p < 0.001). Even after exclusion of patients with ovarian cyst, the ovarian ligament was still significantly longer in the torsion group as compared to the control group (3.2 ± 1.1 vs. 2.2 ± 0.6 cm respectively, p = 0.01). CONCLUSION: Our results suggest that increased length of ovarian ligament might be correlated with the development of ovarian torsion. This could be a basis for ovarian ligament fixation or oophoropexy at the time of conservative surgery for ovarian torsion.


Assuntos
Ligamentos/patologia , Doenças Ovarianas/etiologia , Anormalidade Torcional/etiologia , Adulto , Feminino , Humanos , Laparoscopia , Tamanho do Órgão , Doenças Ovarianas/cirurgia , Estudos Prospectivos , Anormalidade Torcional/cirurgia , Adulto Jovem
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