Green synthesis of ZnO nanocubes from Ceropegia omissa H. Huber extract for photocatalytic degradation of bisphenol An under visible light to mitigate water pollution.

Plastic pollution has become a major environmental problem because it does not break down and poses risks to ecosystems and human health. This study focuses on the environmentally friendly synthesis of ZnO nanocubes using an extract from Ceropegia omissa H. Huber plant leaves. The primary goal is to investigate the viability of these nanocubes as visible-light photocatalysts for the degradation of bisphenol A (BPA). The synthesized ZnO nanocubes have a highly crystalline structure and a bandgap of 3.1 eV, making them suitable for effective visible-light photocatalysis. FTIR analysis, which demonstrates that the pertinent functional groups are present, demonstrates the chemical bonding and reducing processes that take place in the plant extract. The XPS method also studies zinc metals, oxygen valencies, and binding energies. Under visible light irradiation, ZnO nanocubes degrade BPA by 86% in 30 min. This plant-extract-based green synthesis method provides a long-term replacement for traditional procedures, and visible light photocatalysis has advantages over ultraviolet light. The study's results show that ZnO nanocubes may be good for the environment and can work well as visible light photocatalysts to break down organic pollutants. This adds to what is known about using nanoparticles to clean up the environment. As a result, this study highlights the potential of using environmentally friendly ZnO nanocubes as a long-lasting and efficient method of reducing organic pollutant contamination in aquatic environments.

Interaction between diterpene icetexanes and old yellow enzymes of Leishmania braziliensis and Trypanosoma cruzi.

Old Yellow Enzymes (OYEs) are flavin-dependent redox enzymes that promote the asymmetric reduction of activated alkenes. Due to the high importance of flavoenzymes in the metabolism of organisms, the interaction between OYEs from the parasites Trypanosoma cruzi and Leishmania braziliensis and three diterpene icetexanes (brussonol and two analogs), were evaluated in the present study, and differences in the binding mechanism and inhibition capacity of these molecules were examined. Although the aforementioned compounds showed poor and negligible activities against T. cruzi and L. braziliensis cells, respectively, the experiments with the purified enzymes indicated that the interaction occurs by divergent mechanisms. Overall, the ligands' inhibitory effect depends on their accessibility to the N5 position of the flavin's isoalloxazine ring. The results also indicated that the OYEs found in both parasites share structural similarities and showed affinities for the diterpene icetexanes in the same range. Nevertheless, the interaction between OYEs and ligands is directed by enthalpy and/or entropy in distinct ways. In conclusion, the binding site of both OYEs exhibits remarkable plasticity, and a large range of different molecules, including that can be substrates and inhibitors, can bind this site. This plasticity should be considered in drug design using OYE as a target.

Sustainability assessment of biofuel and value-added product from organic fraction of municipal solid waste.

The current study aims to examine the techno-economic and environmental assessment of biorefinery development within a circular bioeconomy context by using an organic fraction of municipal solid waste (OFMSW) by extraction of lipids, carbohydrates, and proteins with 98, 51 and 62 % by mass of conversion efficiency and yield recovery, and value-added fractions production as well. Fatty acid methyl ester (biodiesel) and glycerol (biofuel) were produced by applying transesterification process, and the remaining biomass was converted into biocrude oil by thermal liquefication. The biorefinery using 613 kg of OFMSW produced biodiesel, glycerol, and bioethanol with 126 litter, 14.3 kg, and 172 litter respectively, as well as value-added fractions, such as biocrude oil with 78 kg. The environmental impact was assessed using the life cycle assessment (LCA) framework, ReCiPe2016 Mid-point (H) approach, through 18 different environmental categories. The key findings elucidate that Terrestrial ecotoxicity, Climate change, Fossil depletion and Human toxicity were the main impact categories which are potentially contributed 9.81E+02 kg 1,4-DB eq., 1.43E+03 kg CO2 eq., 2.04E+02 kg oil eq., and 8.08E+01 kg 1,4-DB eq. The normalization (person per equivalent) analysis revealed that only categories of resource reduction (fossil and metal depletion) are the key contributors to environmental degradation. The biorefinery system's total revenue was estimated at USD 6.817,509 million annually. The calculated revenue was USD 0.026 million daily in a shift of 8 h. The Net present worth (NPW) was calculated at USD 499.97 million by assuming a discount factor of 10 % and inflation rate of 5 % for 15 years. The project is considered feasible by demonstrating 7.15 payback year. This research showcased the efficient portrayal of the biorefinery system and succinctly conveyed the significant circular bioeconomy for a greener future. Thus, it could be helpful to the stakeholder's context towards techno-economic and environmental evaluation.

Empirical analysis of cost-effective and equitable solid waste management systems: Environmental and economic perspectives.

The solid waste management (SWM) system is in a transitional phase in developing economies, and local municipalities and waste management companies are stepping toward integrating a waste treatment approach in the scheme of waste handling. However, there is an urgent need to explore cost-effective techniques, models, and potential revenue streams to sustain the state-run waste sector self-sufficiently. The proposed SWM model aims to support the local waste sector in Islamabad, the capital city of Pakistan, with 100% service area coverage to attain environmental and economic sustainability by defining dedicated waste collection streams to ensure quality material recovery under a cost-effective approach and modality. The innovative approach is applied to allocate the tonnage to various streams as per the city's current land use plan. The estimated/cost of the cleanliness services will be USD13.1 million per annum with an estimated per ton cost of USD 23. The establishment of the proposed material recovery facility (MRF) will process about 500 t/d of waste to produce 45 t/d compost and recover 130 t/d of recyclables. The environmentally friendly model saves 2.4 million tons of CO2‒eq/month from composting and recycling. The average economic potential from MRF and debris-crushing plants, including environmental benefit value, is calculated as USD 3.97 million annually. Recovery of services fee (70%) for various collection streams based on city land use and socio-economic conditions will generate revenue of USD 7.33 million annually. The total revenue will be USD 11.31 million (86% of total annual expenditures) to track the sector's self-sufficiency. To successfully reach the Sustainable Development Goals (SDGs) and Nationally Determined Contributions (NDCs), engaging the private sector from environmentally advanced economies to collaborate in the waste sector to enhance local technical capabilities is recommended.

Benign-by-design plant extract-mediated preparation of copper oxide nanoparticles for environmentally related applications.

A facile, cost-competitive, scalable and novel synthetic approach is used to prepare copper oxide (CuO) nanoparticles (NPs) using Betel leaf (Piper betle) extracts as reducing, capping, and stabilizing agents. CuO-NPs were characterized using various analytical techniques, including Fourier-transform infrared (FTIR) spectroscopy, ultraviolet-visible (UV-Vis) spectroscopy, scanning electron microscopy (SEM), X-ray diffraction (XRD), high-resolution transmission electron microscopy (HRTEM), as well as photoluminescence (PL) measurements. The activity of CuO-NPs was investigated towards Congo red dye degradation, supercapacitor energy storage and antibacterial activity. A maximum of 89% photodegradation of Congo red dye (CR) was obtained. The nanoparticle modified electrode also exhibited a specific capacitance (Csp) of 179 Fg-1. Furthermore, the antibacterial potential of CuO NPs was evaluated against Bacillus subtilis and Pseudomonas aeruginosa, both strains displaying high antibacterial performance.

Green tea waste-derived carbon dots: efficient degradation of RhB dye and selective sensing of Cu2+ ions.

Herein, we have synthesized carbon dots (CDs) using a one-step hydrothermal method from green tea waste, a biomass-derived source with high fluorescent properties and excellent solubility in water. The synthesis of CDs was confirmed through a comprehensive range of characterization techniques, including HRTEM (high-resolution transmission electron microscopy), XPS (X-ray photoelectron spectroscopy), and EDX (energy-dispersive X-ray spectroscopy). The optical properties of the synthesized CDs were assessed using UV-Vis spectroscopy and fluorescence (FL) spectroscopy. The CDs displayed exceptional stability across a wide pH range and various concentrations. Moreover, these CDs exhibited a photoluminescence quantum yield (PLQY) of 21.6%, indicating their efficiency in emitting fluorescent light upon excitation. The CDs also showcased their prowess in fluorometrically detecting Cu2+ ions, displaying high sensitivity and selectivity. They presented two distinct linear ranges: 0.02 to 50 µM and 50 to 100 µM, with recovery rates ranging from 94.2 to 104.06%. Moreover, under visible light irradiation, the CDs exhibited significant efficiency in the photocatalytic removal of dyes. Specifically, the CDs achieved degradation rate of 97.89% for Rhodamine B (RhB) within a 30-min irradiation period. In the context of RhB adsorption, it is evident that the experimental data align more closely with the Freundlich isotherm than the Langmuir isotherm. This is substantiated by a higher R2 value (0.97) for the Freundlich isotherm model compared to the Langmuir adsorption isotherm model (0.93). Notably, the adsorption kinetics was effectively described by pseudo first-order kinetics models. Overall, these results highlight the promising potential of CDs in applications such as environmental remediation and waste treatment processes due to their photocatalytic and sensing capabilities.

Rice cultivation and processing: Highlights from a life cycle thinking perspective.

The agri-food sector needs both water and energy and it also contributes to greenhouse gas (GHG) emissions; among the various activities within this sector, rice production has a particularly significant impact on the environment. Life Cycle Assessment (LCA) is one of the widely used approaches for evaluating the environmental impacts of a product, and as such, it is useful for examining the impacts of the rice industry. In recent years, LCA has been increasingly utilized to provide detailed insight into rice production processes. This review focuses on the application of LCA in rice production. Rice LCA studies were gathered in Scopus®. A total of 76 papers were examined up to the end of 2022. Most studies have evaluated the environmental impact of rice production and identified problem areas and opportunities for improvement. But there is a discrepancy in inputs considered, multifunctionality, emissions estimation and use of FU, which makes it challenging to compare LCA results, while some key aspects such as loss of biodiversity and variation of soil organic carbon and fertility are often not considered or roughly modelled. Only a small number (13 studies) evaluated economic consequences and investigated the impact of rice production on biodiversity (4 studies), indicating a stronger focus on environmental rather than socioeconomic aspects and limitations in evaluating certain environmental effects such as biodiversity and soil fertility.

Potential health risk assessment, spatio-temporal hydrochemistry and groundwater quality of Yamuna river basin, Northern India.

Groundwater which is an essential source of freshwater for various domestic, agricultural, industrial applications is facing a severe deterioration in quality due to demographic pressure and intense industrial activities. Present study appraises the influence of human induced activities on groundwater quality of Agra-Firozabad industrial belts of Western Uttar Pradesh, Yamuna basin, India. The maximum concentrations of metals and anions found during pre and post monsoon are as follows: Lead 0.302; 0.086, calcium 672; 1260, magnesium 215; 16.8, cadmium 0.0; 0.066, chromium 0.016; 0.005, manganese 0.340; 0.076, nickel 0.044; 0.028, sulfate 514; 286, nitrate 66.7; 3.56 and fluoride 1.17; 2.02 mg/L respectively. Based on results of Water Quality Index, groundwater samples were classified under 'Poor water' category in 34.2% and 52.63% during pre and post-monsoon period, respectively. Accordingly, higher concentrations of bicarbonate and sulfate might have attributed to excess hardness, instrumental in making it unsuitable for industrial usage. However, values of Percent Sodium, Sodium Adsorption Ratio, Magnesium Hazard and Permeability Index signified that groundwater from majority of locations was fit for agricultural use. Health risk assessment studies revealed that children consuming polluted water were affected more as compared to adults. Timely action and strict compliance of regulation is recommended towards groundwater management for defined usage to avert severe health effects and to meet sustainable development goals.

Synthesis, Structure−Activity Relationships, and Parasitological Profiling of Brussonol Derivatives as New Plasmodium falciparum Inhibitors

Malaria is a parasitic disease caused by protozoan parasites from the genus Plasmodium. Plasmodium falciparum is the most prevalent species worldwide and the causative agent of severe malaria. The spread of resistance to the currently available antimalarial therapy is a major concern. Therefore, it is imperative to discover and develop new antimalarial drugs, which not only treat the disease but also control the emerging resistance. Brussonol is an icetexane derivative and a member of a family of diterpenoids that have been isolated from several terrestrial plants. Here, the synthesis and antiplasmodial profiling of a series of brussonol derivatives are reported. The compounds showed inhibitory activities in the low micromolar range against a panel of sensitive and resistant P. falciparum strains (IC50s = 5-16 µM). Moreover, brussonol showed fast-acting in vitro inhibition and an additive inhibitory behavior when combined with the antimalarial artesunate (FICindex~1). The mode of action investigation indicated that brussonol increased the cytosolic calcium levels within the parasite. Hence, the discovery of brussonol as a new scaffold endowed with antiplasmodial activity will enable us to design derivatives with improved properties to deliver new lead candidates for malaria.

Biotechnological Advances in Pharmacognosy and In Vitro Manipulation of Pterocarpus marsupium Roxb.

Trees are vital resources for economic, environmental, and industrial growth, supporting human life directly or indirectly through a wide variety of therapeutic compounds, commodities, and ecological services. Pterocarpus marsupium Roxb. (Fabaceae) is one of the most valuable multipurpose forest trees in India and Sri Lanka, as it is cultivated for quality wood as well as pharmaceutically bioactive compounds, especially from the stem bark and heartwood. However, propagation of the tree in natural conditions is difficult due to the low percentage of seed germination coupled with overexploitation of this species for its excellent multipurpose properties. This overexploitation has ultimately led to the inclusion of P. marsupium on the list of endangered plant species. However, recent developments in plant biotechnology may offer a solution to the overuse of such valuable species if such advances are accompanied by technology transfer in the developing world. Specifically, techniques in micropropagation, genetic manipulation, DNA barcoding, drug extraction, delivery, and targeting as well as standardization, are of substantial concern. To date, there are no comprehensive and detailed reviews of P. marsupium in terms of biotechnological research developments, specifically pharmacognosy, pharmacology, tissue culture, authentication of genuine species, and basic gene transfer studies. Thus, the present review attempts to present a comprehensive overview of the biotechnological studies centered on this species and some of the recent novel approaches for its genetic improvement.

Sustainable biochar: A facile strategy for soil and environmental restoration, energy generation, mitigation of global climate change and circular bioeconomy.

The increasing agro-demands with the burgeoning population lead to the accumulation of lignocellulosic residues. The practice of burning agri-residues has consequences viz. Release of soot and smoke, nutrient depletion, loss of soil microbial diversity, air pollution and hazardous effects on human health. The utilization of agricultural waste as biomass to synthesize biochar and biofuels, is the pertinent approach for attaining sustainable development goals. Biochar contributes in the improvement of soil properties, carbon sequestration, reducing greenhouse gases (GHG) emission, removal of organic and heavy metal pollutants, production of biofuels, synthesis of useful chemicals and building cementitious materials. The biochar characteristics including surface area, porosity and functional groups vary with the type of biomass consumed in pyrolysis and the control of parameters during the process. The major adsorption mechanisms of biochar involve physical-adsorption, ion-exchange interactions, electrostatic attraction, surface complexation and precipitation. The recent trend of engineered biochar can enhance its surface properties, pH buffering capacity and presence of desired functional groups. This review focuses on the contribution of biochar in attaining sustainable development goals. Hence, it provides a thorough understanding of biochar's importance in enhancing soil productivity, bioremediation of environmental pollutants, carbon negative concretes, mitigation of climate change and generation of bioenergy that amplifies circular bioeconomy, and concomitantly facilitates the fulfilment of the United Nation Sustainable Development Goals. The application of biochar as seen is primarily targeting four important SDGs including clean water and sanitation (SGD6), affordable and clean energy (SDG7), responsible consumption and production (SDG12) and climate action (SDG13).

Postpartum depression and its clinico-social correlates - A community-based study in aligarh.

Context: Postpartum depression (PPD) is onset of depressive symptoms in postpartum period from 2 weeks to 1 year. It causes maternal morbidity and long-term negative effects on growth and development of infant and child. It is often unreported and underdiagnosed. Aims: (1) To estimate the prevalence of PPD, (2) To determine socio-demographic, clinical, and obstetric correlates of the same. Settings and Design: A cross-sectional study was done in urban and rural areas of District Aligarh. Methods: A total of 304 females between 6 weeks and 6 months' postpartum period giving consent were included in this study. Sociodemographic, obstetric, and clinico-social factors were recorded using predesigned, pretested questionnaire. Edinburgh Postnatal Depression Scale (EPDS) score ≥10 was used to screen for PPD and International Classification of Disease (ICD-10) criteria for confirmation. Statistical Analysis Used: Correlates of PPD were determined using logistic regression analysis. Results: The prevalence of PPD was 9.5% using EPDS and was confirmed by ICD-10 criteria. History of abortion (adjusted odds ratio [AOR]: 6.0, 95% Confidence Interval [CI] 2.2-16.5), poor relationship with in-laws (AOR: 5.1; 95% CI 1.3-20.5), marital conflict (AOR: 13.3; 95% CI 2.2-77.6), and substance abuse in husband (AOR: 3.1; 95% CI 1.1-9.0) were found to be significant correlates for PPD. Conclusions: About one in every 10 postpartum females suffered from depression but did not seek health care for the same. Women facing social pathologies such as substance abuse in husband, marital conflict, and poor relationship with in-laws are more at risk of PPD. Screening for PPD should be included in the maternal and child health care programs to ensure early diagnosis and treatment.

Facilitators and barriers influencing the post-crash emergency care of road traffic injuries in district Aligarh of Uttar Pradesh.

Context: Road traffic injuries (RTIs) will become the fifth leading cause of death by 2030. It is often possible to mitigate the consequences of serious injury if victims have access to prompt, effective pre-hospital care within minutes following the crash. Aims: To find out the facilitators and barriers for providing post-crash emergency care in Road traffic injuries in district Aligarh. Settings and Design: The present study was undertaken on both the National highways (NH-91 and NH-93) and the bypass roads passing through district Aligarh of Uttar Pradesh. Subjects and Methods: All the individuals who met road traffic accidents (RTA) between the earmarked areas from 1st October 2018 to 30th November 2020 and reported for treatment to the selected hospitals were included in the study. Statistical Analysis Used: Data is presented in the form of frequency tables and percentages. Results: A total of 1126 patients were interviewed during the study period. Out of 1126, 937 (83.2%) were males, and 189 (16.8%) were females, with M:F ratio being 4.96:1. Six hundred sixty-two (58.8%) of the respondents identified the layperson or common man as the first person to respond at the time of the crash. 1110 (98.58%) respondents identified the layperson as the facilitator in providing post-crash emergency care, followed by police and roadside shopkeepers/dhabawalas. The role of the layperson in calling for help by utilizing the helpline numbers, suggesting a nearby health facility together with facilitating for transportation of the victim to the nearby health facility was appreciated by the majority of the respondents. An ambulance was the best available mode of transportation. Seven hundred thirty-three (65.10%) of the total respondents were aware of the toll-free number to be dialled in case of RTA. However, only 320 (43.70%) among them used this toll-free facility after meeting the crash. Conclusion: A layperson is the single most important facilitator for providing post-crash emergency care.

Effect of sewage sludge biochar on the soil nutrient, microbial abundance, and plant biomass: A sustainable approach towards mitigation of solid waste.

Soils functions, fertility, and microbial abundance may alter in various ways by the biochar amendments to the soil. This study revealed the way of pyrolysis temperature influences the biochar quality and its addition for improving soil properties. The SS biochar was synthesized via pyrolysis and characterized by SEM and FTIR for studying surface images and chemical functional groups. The biochar upon addition with soil was studied for physiological parameters of plants like seed germination index, root length, shoot length, biomass, metal (loid) analysis of soil, SS and SS biochar, total organic content, C: N ratio, NPK values, etc. Besides, combinations of biochar: soil {1:3 (25% + 75%), 1:1 (50% + 50%), and 3:1 (75% + 25%)} ratios were used for studying the effect of biochar on soil microbial community. The 16S rRNA metagenomic analysis revealed the dominance of phyla: Proteobacteria, Actinobacteria, and Acidobacteria that influence the soil nutrient cycle when applied at ratio 1:3. This study highlights the valorization of SS into biochar and studied the effect of biochar augmentation with soil; its impact on soil nutrients, microbial abundance, and plant biomass enhancement. The greener approach also mitigates and helps in the sustainable management of solid wastes, thus reducing GHGs emissions and improves nutrient cycling.