1.
JACC Basic Transl Sci
; 5(7): 665-681, 2020 Jul.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32760855
RESUMO
In ST-segment elevation myocardial infarction of both patients and mice, there was a decline in blood eosinophil count, with activated eosinophils recruited to the infarct zone. Eosinophil deficiency resulted in attenuated anti-inflammatory macrophage polarization, enhanced myocardial inflammation, increased scar size, and deterioration of myocardial structure and function. Adverse cardiac remodeling in the setting of eosinophil deficiency was prevented by interleukin-4 therapy.