RESUMO
We describe an experimental model of acute pancreatitis in conscious rats, based on biliary reflux; sodium deoxycholate was injected while maintaining the common duct (biliary and pancreatic) temporally occluded. A progressive increase of serum amylase, cardiac rate and hematocrit value, as well as a decrease of plasma proteins are characteristic of this experimental model. Blood pressure was maintained until shortly before death, which occurred after 85 minutes. This is a simple model, reliable and reproducible, which requires minimal surgical manipulation.
Assuntos
Pancreatite/fisiopatologia , Doença Aguda , Animais , Ducto Colédoco/fisiologia , Ácido Desoxicólico , Modelos Animais de Doenças , Masculino , Pancreatite/induzido quimicamente , Ratos , Ratos EndogâmicosRESUMO
Isolated obstruction of the splenic vein leads to the appearance of a relatively uncommon form of portal hypertension, the diagnosis of which depends on a high rate of awareness, and it can be successfully treated by splenectomy. A case is described of segmental portal hypertension, with special emphasis on the difficulty of its diagnosis and the measures used. Therapeutic possibilities are commented.