1.
J Neurosurg
; 93(5): 900, 2000 Nov.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11059680
2.
Biochem Biophys Res Commun
; 205(3): 1843-9, 1994 Dec 30.
Artigo
em Inglês
| MEDLINE
| ID: mdl-7811273
RESUMO
Mobilization of [Ca2+]i in the monkey hippocampal slices during transient hypoxia-hypoglycemia and KCl-induced depolarization was analyzed by microfluorometric imaging and anti-PIP2 immunohistochemistry. Hypoxia-hypoglycemia provoked the largest [Ca2+]i mobilization of CA-1 temperature-dependently whereas [Ca2+]i mobilization by KCl-induced depolarization occurred independent of the temperature in CA-2. Immunohistochemical analysis of the hippocampus after hypoxia-hypoglycemia showed an increased PIP2 staining preferentially in the perikarya of CA-1 neurons. These data suggest that release of Ca2+ from intracellular stores caused by PIP2 breakdown may induce elevated [Ca2+]i.