RESUMO
Reticulate acropigmentation of Dohi is a rare dyschromic disorder that generally has an autosomal dominant pattern of inheritance. Most of the cases have primarily been described from Japan. Only a few similar cases have been described elsewhere. We describe 3 black siblings, one boy and two girls, who had progressive reticulate hyperpigmented and hypopigmented macules over the dorsa of hands and feet, which began in early childhood. There were no palmar pits or breaks of the epidermal rete ridge pattern nor was there a family history of any pigmentary skin diseases. Three skin biopsies were performed on one patient; a biopsy specimen from a hyperpigmented macule showed increased melanin in all epidermal levels tapering towards the surface, a second biopsy specimen from a hypopigmented macule showed much less melanin, but it had a similar distribution. A third specimen from a hyperpigmented macule for electron microscopy showed a moderate number of stage III and IV melanosomes in the cytoplasm of the melanocytes. To our knowledge, these patients are the first cases reported from the Middle East with an autosomal recessive pattern of inheritance, confirming previous reports.
Assuntos
Hiperpigmentação/genética , Hipopigmentação/genética , Adolescente , Adulto , Feminino , Humanos , Hiperpigmentação/patologia , Hipopigmentação/patologia , Masculino , LinhagemRESUMO
Although scleromyxedema has been associated with neoplasm in rare instances, the literature showed no evidence of association with seminoma. We report a 43-year-old man who presented with a scleromyxedema and relapsed seminoma. The skin lesions of scleromyxedema cleared completely on treatment of seminoma with chemotherapy.
Assuntos
Mixedema/etiologia , Esclerodermia Localizada/etiologia , Seminoma/complicações , Neoplasias Testiculares/complicações , Adulto , Humanos , Masculino , Mixedema/patologia , Esclerodermia Localizada/patologia , Seminoma/terapia , Neoplasias Testiculares/terapiaAssuntos
Dermatite Alérgica de Contato/diagnóstico , Dermatite Alérgica de Contato/etiologia , Fármacos Dermatológicos/efeitos adversos , Terpenos/efeitos adversos , Cicatrização/efeitos dos fármacos , Administração Cutânea , Adulto , Diagnóstico Diferencial , Hérnia Inguinal/cirurgia , Humanos , Masculino , Testes do EmplastroRESUMO
Amyloidosis in association with Systemic Lupus Erythematosus (SLE) has rarely been reported. We report a patient with "SLE" and Amyloidosis presenting with recurrent bloody diarrhea and review the relevant literature.