RESUMO
Anti-interleukin-17A (anti-IL-17A) therapy has been increasingly employed as a treatment option for pityriasis rubra pilaris (PRP). In this study, we reviewed all available studies on this topic in the literature to evaluate the efficacy and safety of anti-IL-17A. Our main objective was to assess the current evidence on the efficacy and safety of anti-IL-17A therapy in the management of PRP. We searched for relevant articles on PubMed, MEDLINE, Ovid, Embase, and the Web of Science electronic databases from inception until 2022. Our inclusion criteria were as follows: randomized controlled trials (RCTs), quasi-randomized trials, or prospective observational studies that include PRP patients treated with biological treatments; studies that report clinical outcomes; and studies that compare the treatment modalities, including anti-IL-17, in the English language. A total of 19 articles involving 77 cases were reviewed after applying the inclusion criteria and removing duplicates. We found that type 1 PRP was the most common condition irrespective of gender, and the trunk was the most affected area. The study showed that IL-17 inhibitors had a significant impact on the patients. However, higher-level studies are required to further evaluate the therapeutic and safety effects of the treatment.
RESUMO
BACKGROUND: Intentional outdoor tanning is the process through which people expose their skin to ultraviolet (UV) radiation to darken their skin color toward brown or bronze. UV radiation is a well-known modifiable risk factor for photoaging, photoallergic reactions, and phototoxicity. OBJECTIVE: The aim of this study was to assess the behaviors and knowledge of intentional outdoor tanning among adults in the western region of Saudi Arabia. METHODS: A cross-sectional study was conducted among 1023 adults from the general population who met the eligibility criteria. Data were collected in October and November 2022 using an electronic questionnaire to assess the sociodemographic data, behaviors, and knowledge of the participants related to intentional outdoor tanning. RESULTS: Overall, 24.5% of the participants intentionally tanned outdoors, the majority of which (203, 80.9%) were exposed to the sun for more than 20 minutes. The participants who intentionally tan outdoors were significantly younger than those who do not (32 ± 10.7 vs. 38.4 ± 13.9, respectively, P <0.001). Most of the participants had good knowledge of the disadvantages of sun exposure on the skin (61.3%). Additionally, good knowledge was significantly more prevalent in women (70.3%) than men (48.6%) (P <0.001). CONCLUSION: Individuals who intentionally tan outdoors engage in other behaviors or beliefs that increase exposure to UV rays. This points to the need for comprehensive interventions such as community-counseling campaigns to address these new trends and their relationship with photoaging and skin cancer.
