New developments in sensor technology for water quality surveillance and early warning.

Sensor technologies offer particular advantages for surveillance, early warning and process control. This work aimed to provide information about practical new sensing devices that can be used for rapid field assessment of water pollution. A questionnaire completed in 2002 gathered information and data for a catalogue of sensors and instruments that can potentially be applied to soils, sediments, surface and groundwater. Demonstrations of practical sensing technologies took place at a former metal mining site near to Sevilla in 2002, and focusing on diffuse pollution in Koblenz in 2003. These exercises have confirmed that sensors and analytical methodologies can be applied on site to determine various analytes. The instruments provided information useful to manage existing water pollution problems. Some of the scientific innovations of the newest technologies consisted of improved sensitivity, the improved relevance of assays based on biomarkers, the reduced impact on the environment and the capability to detect new contaminants. Sensor technologies were also found to be useful to detect the effects of pollutant mixtures. The portability of these instruments is advantageous for on site and in situ analyses. They will help industry and regulators to deal with existing pollution and attain good water quality.

Measurement of antipsychotic-induced side effects: support for the validity of a self-report (LUNSERS) versus structured interview (UKU) approach to measurement.

A self-report measure of antipsychotic side effects (LUNSERS) was compared with that of an established semi-structured interview (UKU side effect rating scale). The validity and the ability of the LUNSERS to determine false positives by use of an internal 'red herring' subscale were assessed. 'Red herring' items are those which do not directly relate to known antipsychotic side effects. In an open study, 29 patients with schizophrenia and schizoaffective disorder from inpatient and outpatient settings within an Australian metropolitan mental health service were assessed for antipsychotic-induced side effects using both the LUNSERS and UKU. The LUNSERS and UKU were similar in their overall assessment of antipsychotic side effects (total score correlation of 0.58) and were correlated on a wide array of individual side effect items. Correlations between total scores and individual items were higher for those patients scoring low on the LUNSERS 'red herring' items compared with both those with high 'red herring' scores and the sample as a whole. Several LUNSERS items were identified as potentially problematic, requiring further explanation or supplementation with direct questioning. The 'red herring' scale appears to enable detection of patients that may be over-reporting symptomatology. The LUNSERS is a valuable self-report measure of antipsychotic side effects, particularly in cases where red herring scores are low.

Atropine acts in the ventral striatum to reduce raclopride-induced catalepsy.

While muscarinic receptor antagonists are used to reduce motor side effects associated with the use of antipsychotic drugs, their site of action remains unclear. The study investigated the site of action of the non-selective muscarinic receptor antagonist atropine on catalepsy induced by the selective dopamine D2 receptor antagonist, raclopride. Initially, catalepsy and striatal muscarinic receptor occupancy was assessed 2 h following subcutaneous injection of raclopride and either atropine or vehicle. Catalepsy was significantly reduced by doses of atropine that occupied more than 69% of muscarinic receptors. Next, atropine was injected bilaterally into the ventral striatum, which produced a significant reduction in catalepsy, while injections into the dorsal striatum and substantia nigra had no effect. The site of atropine's action was localised to a discrete area of the ventral striatum through the use of quantitative autoradiographic techniques. These findings provide further evidence for the importance of the ventral striatum in the expression of behaviours.

The design and development of new chemical sensors for in vivo monitoring.

The latest workshop of the European Community (EC) Concerted Action on 'Chemical sensors for in vivo monitoring' was held in Nauplion, Greece, in April this year. This fifth workshop focused on 'The design and development of new sensors for in vivo monitoring', and was organized into five sessions: design and development of new sensors; operational considerations; performance of analytical systems; novel sensors/tissue heterogeneity; and infra-red spectroscopy.