Noise-Induced Hearing Loss Awareness and Prevention: A Cross-Sectional Study Among the Population of the Southern Region of Saudi Arabia.

BACKGROUND: Noise-induced hearing loss (NIHL) is a prevalent and preventable health issue globally. This study aims to evaluate the symptoms, knowledge, beliefs, and preventive practices regarding NIHL among the general population of the southern region of Saudi Arabia. MATERIALS & METHODS: A cross-sectional study was conducted from May to July 2024, using a self-administered, validated electronic questionnaire distributed in Arabic via social media platforms. The questionnaire assessed socio-demographic data, NIHL awareness, attitudes toward prevention, and personal practices regarding noise exposure. The sample included 400 participants analyzed using SPSS version 23 (IBM Corp., Armonk, NY), with associations measured through the chi-square and Fisher's exact tests. RESULTS: Most participants were Saudi nationals (97%) and females (81.3%). Symptoms of NIHL, such as tinnitus and the need to increase TV or radio volume, were prevalent among participants. Most participants (88.5%) were aware that high sound levels affect hearing, yet only 9.5% correctly identified the minimum duration of exposure that could harm hearing. Social media was the primary source of information (51.3%). Positive preventive practices were noted, with 66% lowering device volumes and 55.3% recommending sound restrictions on tablets. Significant associations were found between better preventive practices and higher income as well as marital status. CONCLUSION: The study highlights the high basic awareness of NIHL but identifies critical knowledge gaps regarding the minimum sound level and duration that affect hearing negatively. Enhanced public health education and technological interventions are needed to improve prevention practices. Future research should include longitudinal studies and diverse populations to better understand and address NIHL.

Free sugar intake is associated with reduced proportion of circulating invariant natural killer T cells among women experiencing overweight and obesity.

Background: Higher prevalence of obesity has been observed among women compared to men, which can be explained partly by the higher consumption of sweets and physical inactivity. Obesity can alter immune cell infiltration, and therefore increase the susceptibility to develop chronic inflammation and metabolic disorders. In this study, we aimed to explore the association between free sugar intake and other unhealthy lifestyle habits in relation to the proportion of circulating iNKT cells among women with healthy weight and women experiencing overweight and obesity. Methods: A cross-sectional study was conducted on 51 Saudi women > 18 years, wherein their daily free sugar intake was assessed using the validated Food Frequency Questionnaire. Data on smoking status, physical activity, and supplement use were also collected. Anthropometric data including height, weight, waist circumference were objectively measured from each participants. The proportion of circulating iNKT cells was determined using flow cytometry. Results: Smoking, physical activity, supplement use, and weight status were not associated with proportion of circulating iNKT cells. Significant association was found between proportion of circulating iNKT cells and total free sugar intake and free sugar intake coming from solid food sources only among women experiencing overweight and obesity (Beta: -0.10: Standard Error: 0.04 [95% Confidence Interval: -0.18 to -0.01], p= 0.034) and (Beta: -0.15: Standard Error: 0.05 [95% Confidence Interval: -0.25 to -0.05], p= 0.005), respectively. Conclusion: Excessive free sugar consumption may alter iNKT cells and consequently increase the risk for chronic inflammation and metabolic disorders.

Comparative Assessment of Drug Lag for Approved Oncology Targeted Therapies Between Saudi Arabia, the United States, and the European Union.

INTRODUCTION: Pharmaceutical regulation on a global scale is a complex process, with regulatory bodies overseeing various aspects, including licensing, registration, manufacturing, marketing, and labeling. Among these, the USFDA plays a crucial role in upholding public health. The pharmaceutical industry contributes significantly to well-being by developing and distributing therapeutic agents. The journey of evaluating new pharmaceuticals involves meticulous examination through several phases, from safety and efficacy assessments to toxicity evaluation. Drug approval involves submitting New Drug Applications (NDAs) to regulatory agencies like the USFDA and EMA. However, disparities in durations contribute to the phenomenon known as "drug lag." This lag refers to delays in a pharmaceutical product's availability in one market compared to another. Addressing this issue is crucial, given its impact on patient access to treatments. METHOD: This study aims to analyze the extent of drug lag, focusing on newly approved oncology targeted therapies in Saudi Arabia, the United States, and the European Union. Data for cancer treatments authorized by the USFDA, EMA, and SFDA from January 1, 1997, to December 31, 2022, were collected from regulatory agency websites. The data sources included authorization letters, prescription information, and evaluation documents. We conducted a comparative assessment of drug lag for approved oncology targeted therapies between Saudi Arabia, the US, and the EU. RESULT: Our analysis identified 135 newly approved oncology-targeted drugs within the specified timeframe. Of these, 71 received approval in all three regions, while disparities were evident in others. The USFDA consistently had the highest number of approved drugs, with 98.5% of drugs initially approved there. In contrast, Saudi Arabia had the lowest number of approved drugs and a significantly longer median drug lag, indicating substantial delays in drug availability. CONCLUSION: This study highlights the significance of mitigating drug lag to enhance global healthcare outcomes and patient access to innovative therapies. Further research and collaborative efforts are essential to bridging these disparities and promoting equitable healthcare worldwide.

Diabetes education self-management intervention in improving self-efficacy for people with type 2 diabetes in the Gulf Cooperation Council countries: A systematic review.

AIMS: This research aims to evaluate the effectiveness of diabetes education self-management intervention for improving self-efficacy for people with type 2 diabetes mellitus in the Gulf Cooperation Council countries. METHODS: The Joanna Briggs Institute's methodology was applied to conduct a systematic review of type 2 diabetes interventions published from 2012 to 2022. This involved searching major databases, including Ovid, CINAHL, Scopus, Web of Science, and PubMed, with specific inclusion and exclusion criteria. The focus was on studies involving adults aged 18 or older with a Type 2 Diabetes (T2D) diagnosis, randomized controlled trials, and full-text English-language articles, while excluding materials such as editorials and conference abstracts. RESULTS: A total of 689 relevant articles initially retrieved; ultimately, only five studies met the inclusion criteria of this review. All five included studies were randomised control trials, and all five studies indicated that there was a significant and positive impact of diabetes education self-management intervention on diet and physical activities. Furthermore, three of the included studies indicated that interventions led to a substantial reduction in the levels of glycosylated haemoglobin (HbA1c) among people with type 2 diabetes. CONCLUSIONS: Diabetes education is an effective way of improving the health outcomes of people with type 2 diabetes. Diabetes education self-management interventions significantly increase the self-efficacy of people with Type 2 Diabetes (T2D) by enabling them to effectively control their blood glucose levels. Therefore, this study recommended that the GCC countries need to implement education intervention programmes to help and support people with Type 2 Diabetes.

Diabetes Mellitus Knowledge, Attitudes, Preventive Practices and Associated Factors Among a Sample of Adult Non-Diabetic Saudi Residents.

Purpose: To assess the diabetes mellitus (DM) knowledge, attitudes, preventive practices, and associated factors among a sample of adult non-diabetic Saudi residents. Methods: The present survey was conducted in April-June 2022. People from the general population were invited to participate in the study, and the data were collected using a validated questionnaire. Results: A total of 1207 non-diabetic subjects participated in the study [females 798(66.1%) and males 409(33.9%)], and the response rate was 80% (1207/1500). Two-thirds (66.86%) of non-diabetic adult community members had good knowledge of DM, 47.8% had positive attitudes, and 62.14% maintained a healthy lifestyle to avoid DM. There was a family history of DM in more than half of the subjects 723(59.9%). Participants who had a direct relative with diabetes scored higher on the knowledge question than those who did not (p<0.001). Practice questions responses for preventing DM showed that about 459(38%) were using fatty food less frequently, and only 338(28%) and 153(12.7%) were doing physical activities 30-60 minutes per day frequently and very frequently, respectively. Most participants were smoking tobacco, 890(73.7%), and getting checked their BP, 704(58.3%), very frequently. The participants with a master's and Ph.D. degree were likelier to have positive attitudes and good practices than students. Individuals with a history of DM in their families were 2.10 times (OR=2.10, p<0.001), 1.95 times (OR=1.95, p<0.001), and 2.03 times (OR=2.03, p<0.001) more likely to be knowledgeable, had positive attitudes and good practices than those with no DM in their family, respectively. Conclusion:  Over half of the individuals possessed a positive mindset, adequate knowledge, and good practicing behavior for preventing DM. Having Master's and Ph.D. degrees and a family history of DM were associated with a positive attitude and good practices. There is a need to expand community awareness campaigns utilizing social media channels.

Qualitative Assessment of Quality and Readability of Patient-Directed Online Resources for Cochlear Implants in Children.

OBJECTIVE: Children with sensorineural hearing loss can benefit from cochlear implantation (CI). Patients can obtain direct access to medical information on the internet. However, the internet is uncontrolled, and the quality and readability of information are unpredictable. The quality and readability of websites providing information about CI in children were assessed in this study. STUDY DESIGN: Cross-sectional study. SETTING: Online search. METHODS: The 3 most popular search engines (Google, Bing, and Yahoo) were queried with the phrases "cochlear implant" and "cochlear implant in children." The DISCERN instrument was used to assess the information quality. The readability was evaluated using 5 validated readability indices. RESULTS: Of 103 websites, the median DISCERN quality score was 33 (interquartile range [IQR], 27-41). Only 5 websites were considered to be of good quality, and 1 was excellent. The median readability school grade was 11th (IQR, 10-12), which fell within the range defined as difficult. No website was at or below the recommended sixth-grade level. There was no correlation between readability and the DISCERN scores (r = -0.105, p = .291). CONCLUSION: Our study suggests that most websites with information on CI for children are of variable quality and are written beyond the reading ability of the general population. Website builders should focus on improving the readability of their online material to help the average reader understand and benefit from the content.

Generalized Anxiety Disorder Associated With Gastroesophageal Reflux Disease Among the Saudi Population.

Objectives In Saudi Arabia, the prevalence of generalized anxiety disorder (GAD) was reported to be 29%. As a result, our goal was to examine the association between GAD and gastroesophageal reflux disease (GERD) within the general Saudi Arabian population, as well as to access the risk factors for GAD in order to gain a better understanding. Method This cross-sectional study involved 4,224 participants who completed a questionnaire. Anxiety was assessed using the General Anxiety Disorder-7 (GAD-7) scale, and the GerdQ tool was used to evaluate GERD. Result The prevalence of anxiety among participants was 29% at cutoff 10, with 73% of anxiety-positive participants being female and only 26.9% being male. Furthermore, the associations between anxiety and GERD were significant as 31.4% of participants with anxiety had GERD, compared to 15.0% of those without anxiety. Conclusion In our finding, there was a significant association between anxiety and GERD among the general Saudi population. In terms of anxiety risk factors, female, younger age, social status, body mass index, eating fried food, caffeinated drinks, diabetes miletus, high blood cholesterol, NSAID use, antidepressants, and anti-anxiety medication were found to have a significant association.

Common Causes of Failed Septoplasty: A Systematic Review.

Failed septal correction is an undesirable outcome of primary septoplasty. In this systematic review, we aimed to assess all current studies concerning septoplasty failure, with a view to identifying its common causes. A systematic literature search was conducted by screening the PubMed, MEDLINE, Embase, and Cochrane Library databases for studies that assessed septoplasty failure and were published between January 2008 and January 2021. Three authors independently extracted information from each study and examined all included articles for bias. Four articles provided pertinent data regarding septoplasty failure. We gathered that missed nasal valve abnormality diagnosis, insufficient separation and resection of the bony-cartilaginous junction, and insufficient correction of caudal septal deviation could cause septoplasty failure. Additionally, iatrogenic problems, nasal asymmetry, and side-wall concavity involving the nasofrontal and columellar labial angles are contributing factors. Determining the cause of nasal blockage is challenging because it is subjective. Based on our findings, we concluded that in all patients with septal deviation, utmost care should be taken to avoid overlooking nasal valve abnormalities and other nasal diseases before conducting septoplasty. Moreover, inadequate correction of caudal septal deviation should be avoided. Furthermore, there is currently no widely accepted classification system for septal abnormalities to measure and describe septal deviation characteristics, making surgical planning and documentation difficult. Hence, further research that would lead to the creation of such a classification system is warranted.