RESUMO
El tratamiento convencional para la granulomatosis de Wegener, que incluye esteroides y ciclofosfamida, no es suficiente para el control de la actividad de la enfermedad en algunos pacientes considerados refractarios y conlleva cierta toxicidad relacionada al mismo. La depleción de células B con rituximab ha demostrado ser efectivo en el tratamiento de varias enfermedades autoinmunes, incluyendo las vasculitis sistémicas asociadas a anticuerpos anticitoplasma de neutrófilos (ANCA). Reportamos tres casos de granulomatosis de Wegener refractarios tratados exitosamente con rituximab.
Conventional therapy for Wegener's granulomatosis, steroid and cyclophosphamide, fails to control disease activity in same refractorypatients and has treatment-related toxicity. B cell depletion therapyusing rituximab has been shown to be effective for certain autoimmunediseases, including antineutrophil cytoplasmic antibody (ANCA) associated vasculitis. We report three refractory cases of Wegeners granulomatosis successfully treated with rituximab.
Assuntos
Anticorpos , Granulomatose com Poliangiite , NeutrófilosRESUMO
Argentine population genetic structure was examined using a set of 78 ancestry informative markers (AIMs) to assess the contributions of European, Amerindian, and African ancestry in 94 individuals members of this population. Using the Bayesian clustering algorithm STRUCTURE, the mean European contribution was 78%, the Amerindian contribution was 19.4%, and the African contribution was 2.5%. Similar results were found using weighted least mean square method: European, 80.2%; Amerindian, 18.1%; and African, 1.7%. Consistent with previous studies the current results showed very few individuals (four of 94) with greater than 10% African admixture. Notably, when individual admixture was examined, the Amerindian and European admixture showed a very large variance and individual Amerindian contribution ranged from 1.5 to 84.5% in the 94 individual Argentine subjects. These results indicate that admixture must be considered when clinical epidemiology or case control genetic analyses are studied in this population. Moreover, the current study provides a set of informative SNPs that can be used to ascertain or control for this potentially hidden stratification. In addition, the large variance in admixture proportions in individual Argentine subjects shown by this study suggests that this population is appropriate for future admixture mapping studies.