RESUMO
Studies of low birth weight offspring have a long history in pig science. These pigs have reduced growth potential and poor carcass quality compared to their higher birth weight littermates. In contemporary commercial sows with between 10 and 15 total pigs born/litter, between-litter differences in average birth weight appear to make the largest contribution to variation in postnatal growth performance, independent of numbers born. Low birth weight is a characteristic of a subpopulation of these sows, likely as a consequence of an imbalance between ovulation rate and uterine capacity due to ongoing selection for litter size. Based on experimental studies, we hypothesize that increased crowding at day 30 of gestation primarily affects placental development and persistent negative impacts on placental growth then affect fetal development. However, embryonic myogenic gene expression is already affected at day 30. Latent effects of metabolic state on oocyte quality and early embryonic development have also been reported. In contrast to effects of uterine crowding, the embryo is primarily affected by previous catabolism. The large body of literature on gene imprinting, and the interactions between metabolism, nutrition, and methylation state, suggest that classic imprinting mechanisms may be involved. However, the potential use of genomics, epigenomics, nutrigenomics, and proteomics to investigate these mechanisms brings new demands on experimental design and data management that present a considerable challenge to the effectiveness of future research on prenatal programming in the pig.
Assuntos
Animais Recém-Nascidos/crescimento & desenvolvimento , Desenvolvimento Embrionário/fisiologia , Prenhez/fisiologia , Suínos/crescimento & desenvolvimento , Animais , Animais Recém-Nascidos/fisiologia , Peso ao Nascer/fisiologia , Feminino , Tamanho da Ninhada de Vivíparos/fisiologia , Gravidez , Suínos/fisiologiaRESUMO
We present a case of acute hepatitis caused by dengue virus, with a significant increase in aspartate transferase and alanine transferase levels in a chronic hepatitis patient attended at the Cane Sugar Planters Hospital of Campos dos Goytacazes, RJ.
Assuntos
Idoso , Humanos , Masculino , Dengue/complicações , Hepatite Viral Humana/virologia , Cirrose Hepática/patologia , Transaminases/sangue , Doença Aguda , Biomarcadores/sangue , Doença Crônica , Dengue/sangue , Dengue/patologia , Hepatite Viral Humana/enzimologia , Hepatite Viral Humana/patologiaRESUMO
We present a case of acute hepatitis caused by dengue virus, with a significant increase in aspartate transferase and alanine transferase levels in a chronic hepatitis patient attended at the Cane Sugar Planters Hospital of Campos dos Goytacazes, RJ.
