Statin use and clinical outcomes in hospitalized COVID-19 patients: A retrospective analysis in Riyadh, Saudi Arabia.

OBJECTIVES: To investigate the relationship between statin use and coronavirus disease-19 (COVID-19) severity. METHODS: This was a retrospective study of adult patients with confirmed COVID-19 who were hospitalized at Prince Mohammed Bin Abdulaziz Hospital, Riyadh, Saudi Arabia. The study was carried out from July - September 2020. Antecedent statin use was evaluated using medication information available in the electronic medical records. RESULTS: In this retrospective study, we collected data from 689 patients hospitalized with COVID-19. Among the patients, 56.2% of them were non-Saudi and 67.3% were males. The mean age of the patients was 53.7 years. The most common comorbidities among patients with COVID-19 at admission were hypertension (65.2%) and diabetes mellitus (65%). Among these patients, 155 (22.5%) patients received statins during hospitalization and 79.7% of them received corticosteroids. Receiving statins significantly increased the risk of intensive care unit's admission by 1.64 times, intubation by 1.76 times, developing complications by 2.48 times, and mortality by 3.16 times. CONCLUSION: Statins are associated with a higher risk of mortality and morbidity among patients hospitalized for COVID-19.

Outcomes and complications of diabetic burn injuries: a single center experience.

INTRODUCTION: Comorbid conditions may adversely affect burn outcomes. Burn injuries remain one of the most prevalent injuries presenting to emergency departments. The current study compares the outcomes of burn injuries in diabetic and non-diabetic patients. METHODS: A retrospective review of 705 burn patients admitted to the burn unit was performed. All adult patients (18 years old and above) who were admitted to the burn unit were included. The study compared the complications and outcomes of the diabetic and non-diabetic burn patient. RESULTS: Patient were divided into diabetic (14%) and non-diabetic groups (86%). Diabetic burn patients were more likely to be older with a mean age of 58.7 years compared to 33.6 years in non-diabetic group (P=0.000). Inhalation injury was found in 3% of diabetic group compared to 14% of non-diabetic group (P=0.009). Diabetic patients were more likely to have associated medical comorbidities especially hypertension. Overall mortality rate was 13% and overall length of stay (LOS) was 28.4 days with no significant differences between groups. CONCLUSION: Older age, hypertension and contact burns are significantly associated with DM in burn patients. No increased risk of burn-related infections, mortality and LOS were observed in the DM group.