RESUMO
OBJECTIVE: To determine the high risk HPV (HR-HPV) association with Cervical Intraepithelial Neoplasia (CIN) in women of two Dysplasia Clinics in Mexico City. MATERIAL AND METHODS: Prolective case-control study was done. Women with and without security affiliation attended in Instituto Mexicano del Seguro Social (Hospital 1) and Hospital General de México (Hospital 2) were included in the study. Cases were women with histopathologic diagnosis of CIN and controls were women with negative dysplasia in cytologic study (Pap). Information was obtained by direct interview. HR-HPV was determined by Hybrid Capture II assay, in cervical samples. Bivariate and logistic regression analysis was done. RESULTS: One hundred and two cases and 192 controls from Hospital 1 and 89 cases and 66 controls from Hospital 2 were included. 83.3% and 77.3% of women from Hospital 1 and 2 respectively were positive to HR-HPV. The association HR-HPV and CIN in Hospital 1 was ORa = 40.6, C.I. 95% = 17-96.8; while in Hospital 2 there was not association. Age was an effect modifier in the HR-HVP and CIN association, in Hospital 1. It was observed a correlation between viral load and CIN degree. CONCLUSIONS: The HR-HPV infection frequency in controls and CIN I was higher than the reported in other studies. Age was a modifier in the HR-HPV association and CIN. In dysplasia clinics without medical referral system of patients is possible to observe similar risk factors to cervical cancer.
Assuntos
Papillomaviridae/isolamento & purificação , Infecções por Papillomavirus/epidemiologia , Neoplasias do Colo do Útero/virologia , Adulto , Biópsia , Estudos de Casos e Controles , Sondas de DNA de HPV , DNA Viral/isolamento & purificação , Feminino , Hospitais Gerais , Hospitais Públicos , Humanos , México/epidemiologia , Pessoa de Meia-Idade , Hibridização de Ácido Nucleico , Papillomaviridae/classificação , Papillomaviridae/patogenicidade , Prevalência , Estudos Prospectivos , História Reprodutiva , Fatores de Risco , Inquéritos e Questionários , População Urbana , Displasia do Colo do Útero/epidemiologia , Displasia do Colo do Útero/virologia , Displasia do Colo do Útero/patologia , Neoplasias do Colo do Útero/epidemiologia , Neoplasias do Colo do Útero/patologia , VirulênciaRESUMO
OBJECTIVE: To determine the high risk HPV (HR-HPV) association with Cervical Intraepithelial Neoplasia (CIN) in women of two Dysplasia Clinics in Mexico City. MATERIAL AND METHODS: Prolective case-control study was done. Women with and without security affiliation attended in Instituto Mexicano del Seguro Social (Hospital 1) and Hospital General de MÚxico (Hospital 2) were included in the study. Cases were women with histopathologic diagnosis of CIN and controls were women with negative dysplasia in cytologic study (Pap). Information was obtained by direct interview. HR-HPV was determined by Hybrid Capture II assay, in cervical samples. Bivariate and logistic regression analysis was done. RESULTS: One hundred and two cases and 192 controls from Hospital 1 and 89 cases and 66 controls from Hospital 2 were included. 83.3 and 77.3 of women from Hospital 1 and 2 respectively were positive to HR-HPV. The association HR-HPV and CIN in Hospital 1 was ORa = 40.6, C.I. 95 = 17-96.8; while in Hospital 2 there was not association. Age was an effect modifier in the HR-HVP and CIN association, in Hospital 1. It was observed a correlation between viral load and CIN degree. CONCLUSIONS: The HR-HPV infection frequency in controls and CIN I was higher than the reported in other studies. Age was a modifier in the HR-HPV association and CIN. In dysplasia clinics without medical referral system of patients is possible to observe similar risk factors to cervical cancer.
Assuntos
Humanos , Feminino , Adulto , Pessoa de Meia-Idade , Papillomaviridae , Neoplasias do Colo do Útero , Infecções por Papillomavirus/epidemiologia , Papillomaviridae , Virulência , Biópsia , DNA Viral , Sondas de DNA de HPV , Estudos de Casos e Controles , Displasia do Colo do Útero , Neoplasias do Colo do Útero , Prevalência , Estudos Prospectivos , Fatores de Risco , Hospitais Gerais , México , Hibridização de Ácido Nucleico , História Reprodutiva , Hospitais Públicos , População Urbana , Inquéritos e QuestionáriosRESUMO
La categoría de los tumores limítrofes fue creada dentro del grupo de las neoplasias epiteliales malignas con el fin de describir un grupo his-tológico que tiene por lo general un pronóstico superior al de los carcinomas. Los tumores serosos limítrofes son definidos como neoplasias que manifiestan una proliferación epitelial mayor que la observada en el cistadenoma seroso, pero sin evidencia alguna de destrucción estromal invasiva. Cuando los tumores limítrofes están circunscritos a los ovarios (etapa I) el pronóstico es excelente: después de remover el tumor no es necesario administrar ningún otro tratamiento adyuvante. En el presente trabajo se analizan las características clínicas y patológicas de una mujer con diagnóstico de tumor seroso limítrofe del ovario (etapa I). A la paciente se le realizó histerectomía abdominal total con salpingooforectomía bilateral y omentectomía. El reconocimiento de la conducta clínica y de las diferentes apariencias morfológicas que podrían manifestar los tumores limítrofes es importante para evitar exponer a las pacientes a tratamientos exagerados.
