Genicular artery embolization for recurrent hemarthrosis: A case report.

A 44-year-old otherwise healthy male with a history of trauma and surgical interventions in his right knee presented to the emergency department with repeated hemarthrosis of the right knee. The patient underwent blood tests, X-rays, and magnetic resonance imaging of the knee. A computed tomography angiography revealed blushing of the synovium of the knee. The patient underwent successful embolization of the genicular artery branches. Hemarthrosis did not recur. The use of genicular artery embolization, in our case, not only successfully addressed recurrent hemarthrosis but also underscores its emerging role in comprehensive patient management. This minimally invasive approach, precisely targeting the vascular supply to the affected synovium, offers an effective alternative where conventional therapies may fall short. Beyond symptom relief, it holds promise for preventing hemarthrosis recurrence, a valuable addition to clinicians' interventions for challenging knee joint bleeding cases. Further investigation in larger cohorts and comparative studies may reveal its broader applicability and long-term efficacy, shaping treatment options for recurrent hemarthrosis.

[Bilateral plantar fasciitis after azithromycin treatment].

Tendinopathy is considered an overuse syndrome which usually results from excessive loading of the tendon during vigorous training activity. There are, however, various causes of this condition other than mechanical causes. This is a case report, in which a 42-year-old male suffered from bilateral plantar fasciitis after treatment with azithromycin for gastroenteritis. Azithromycin-induced tendinitis is a rare side effect, but it is important to know about this and other non-mechanical causes of tendinopathy, and to distinguish them from common mechanical causes in order to optimize treatment.

The use of experimental design in the optimization of risperidone biodegradable nanoparticles: in vitro and in vivo study.

The aim of this study was optimization of risperidone (model drug) biodegradable nanoparticles utilizing emulsion-solvent evaporation technique. Box-Behnken design was adopted to optimize the preparation process. Optimized nanoparticles were characterized for surface morphology using scanning electron microscope. Pharmacokinetic parameters were compared with the marketed tablets. Results revealed that the optimized formula showed 297.37 nm, 85.12%, and 59.79% for Y1, Y2, and Y3, respectively. Optimized formula showed significant improved bioavailability compared with marketed tablets. Successful achievement of prolonged risperidone release with improved bioavailability is expected to maximize patients' adherence to their antipsychotic drug therapy and to minimize risk of relapse during maintenance therapy.