[Anaphylaxis secondary to prick-to-prick tests to foods and its risk factors]. / Anafilaxia secundaria a pruebas cutáneas prick-to-prick para alimentos y sus factores de riesgo.

The diagnosis of food allergy requires a proper anamnesis and diagnostic testing with skin prick tests with fresh foods and/or standardized allergen, or specific IgE tests. The risk of systemic reactions is of 15-23 per 100,000 skin tests performed by prick method, specifically anaphylaxis at 0.02%. This paper reports the case of four patients, who while performing prick to prick test with fresh food presented anaphylactic reaction. Implicated foods were fruits of the Rosaceae, Anacardiaceae and Caricaceae families. The severity of anaphylaxis was: two patients with grade 4, one patient grade 2 and one grade 3, all with appropriate response to drug treatment. The risk factors identified were: female sex, personal history of atopy, previous systemic reaction to Hymenoptera venom, prior anaphylaxis to prick tests to aeroallergens. We found that a history of positive skin test for Betulla v, can be a risk factor for anaphylaxis in patients with oral syndrome. During testing prick to prick with food anaphylaxis can occur, so it should be made with aerial red team on hand. The history of positivity Betulla v is an additional risk factor in these patients.

El diagnóstico de alergia alimentaria requiere una anamnesis adecuada y la realización de pruebas diagnósticas, las pruebas cutáneas con alimentos en fresco, con alergenos estandarizados, o con ambos; las pruebas de IgE específica para alimentos son útiles. El riesgo de reacciones sistémicas por pruebas cutáneas por punción es de 15 a 23 por cada 100,000 y el de anafilaxia es de 0.02%. Comunicamos el caso de cuatro pacientes que sufrieron anafilaxia durante la realización de prueba Prick-to-Prick con alimentos frescos. Los alimentos implicados fueron frutas de las familias Rosaceae, Anacardiaceae y Caricaceae. En dos pacientes la anafilaxia fue de grado 4, en una grado 2 y en otra grado 3, todas con adecuada respuesta al tratamiento farmacológico. Los factores de riesgo fueron: sexo femenino, antecedente personal de atopia, reacción sistémica previa a veneno de himenópteros y anafilaxia previa con pruebas por punción para aeroalergenos. Las cuatro pacientes tuvieron síndrome de alergia oral y 50% tenía antecedente de prueba por punción positiva a betuláceas. Durante la realización de pruebas Prick-to-Prick para alimentos los pacientes pueden presentar anafilaxia, por lo que deben realizarse en un área que cuente con equipo rojo. El antecedente de síndrome de alergia oral se observó en todos los casos y la mitad de las pacientes tuvieron positividad a betuláceas, estos antecedentes pueden ser factores de riesgo adicional de anafilaxia dura te la realización de pruebas Prick-to-Prick para alimentos.

[Utility of challenge test in immediate hypersensitivity to hydrocortisone sodium succinate]. / Utilidad de la prueba de reto en hipersensibilidad inmediata a succinato sódico de hidrocortisona.

Corticosteroid hypersensitivity is a complex phenomenon in which many factors interact, such as idiosyncrasy, intolerance or allergic reactions. The prevalence of immediate hypersensitivity reactions to corticosteroids is 0.2%-0.5%. Corticosteroids have major therapeutic implications; thus, when hypersensitivity is suspected, in-vitro and/or in-vivo testing can be performed to confirm diagnosis, being the drug challenge the gold standard. After definitive diagnosis, cross-reactivity among the different corticosteroid groups should be considered, to choose wisely if corticosteroid therapy is still required. In Coopman classification, steroids belonging to groups A, B and D2 have high cross-reactivity, however, more studies are needed to determine the degree of cross-reaction among these drugs. This paper presents the case of a woman, in who hypersensitivity to hydrocortisone succinate was confirmed by drug challenge test.

La hipersensibilidad a corticoesteroides es un fenómeno complejo en el que interactúan múltiples factores como idiosincrasia, intolerancia o alergia. La prevalencia de las reacciones de hipersensibilidad inmediata a corticoesteroides es de 0.2 a 0.5%. Debido a la relevancia terapéutica de los esteroides, es importante confirmar el diagnóstico de hipersensibilidad con pruebas in vivo, in vitro, o ambas, el patrón de referencia es la prueba de reto con el fármaco implicado. Una vez realizado el diagnóstico y en caso de que se requiera continuar con el tratamiento con esteroides, deberá considerarse la reactividad cruzada entre los diferentes grupos propuestos en la clasificación de Coopman, en la que los corticoesteroides pertenecientes a los grupos A, B y D2 tienen una elevada reactividad cruzada entre sí; sin embargo, hacen falta más estudios para determinar el grado de reactividad cruzada entre estos fármacos. Comunicamos el caso de una paciente en la que se confirmó el diagnóstico de hipersensibilidad a succinato de hidrocortisona con la prueba de reto.

[Chronic myeloid leukemia in an adult with common variable immunodeficiency]. / Leucemia mieloide crónica en un adulto con inmunodeficiencia común variable.

BACKGROUND: Common variable immunodeficiency is a primary immunodeficiency, in which from 70 to 80 % of patients have tumors and 25 % of cases are associated with autoimmune diseases. Common variable immunodeficiency patients have a higher incidence of neoplasms, with a risk 12-18 times higher than the general population. There are few cases of common variable immunodeficiency patients with leukemia. CLINICAL CASE: Female of 36 years old, with left upper quadrant pain, early satiety, weight loss of 8 kg in three months and splenomegaly. The complete blood count showed: leukocytosis 206 000/mL, with 8 % blasts, platelets 530 000/mL and hemoglobin 8 mg/dL. Abdominal ultrasound: 19??12 cm splenomegaly. Karyotype BCR/ABL IS 64.20 %, 100 % Philadelphia chromosome. The diagnosis was of chronic myeloid leukemia. Given the presence of recurrent respiratory tract infection, frequent diarrheas and reduced concentrations of IgG, IgM and IgA, common variable immunodeficiency was diagnosed and human immunoglobulin was used successfully. CONCLUSIONS: The association between chronic myeloid leukemia and common variable immunodefficiency is unusual. Given the high frequency of hematological neoplasm in common variable immunodeficiency patients, we suggest that hematological patients with repeated infections and decreased concentrations of immunoglobulin be referred to an immunological evaluation.

INTRODUCCIÓN: la inmunodeficiencia común variable es la inmunodeficiencia primaria más sintomática, 70 a 80 % de los pacientes presentan neoplasias. Existen escasos informes de pacientes portadores de leucemia mieloide crónica e inmunodeficiencia común variable. CASO CLÍNICO: mujer de 36 años, quien inició su padecimiento con dolor en hipocondrio izquierdo, pérdida de peso de 8 kg en tres meses y esplenomegalia. Los resultados de la biometría hemática indicaron cuenta leucocitaria de 206 000/mL, 8 % de blastos, cuenta plaquetaria de 530 000/mL y hemoglobina de 8 g/dL. Con la ultrasonografía abdominal se identificó esplenomegalia de 19 ´ 12 cm. El cariotipo mostró el gen BCR/ABL 64.20 % IS y cromosoma Filadelfia 100 %. Se diagnosticó leucemia mieloide crónica. Por infecciones gastrointestinales y respiratorias frecuentes, así como por concentraciones reducidas de IgG, IgM e IgA, la paciente fue valorada por el servicio de alergia e inmunología clínica, donde se diagnosticó inmunodeficiencia común variable. CONCLUSIONES: la relación de la leucemia mieloide crónica con la inmunodeficiencia común variable es poco frecuente. Es importante que los pacientes portadores de leucemia mieloide crónica que cursen con infecciones de repetición, se realicen cuantificación de inmunoglobulinas séricas y, en caso de disminución de las mismas, sean referidos para su valoración y tratamiento.

[Vitamin D deficiency in patients with common variable immunodeficiency, with autoimmune diseases and bronchiectasis]. / Deficiencia de vitamina D en pacientes con inmunodeficiencia común variable, con enfermedades autoinmunes y bronquiectasias.

BACKGROUND: Vitamin D regulates cellular activity, also it has effects on: innate and adaptive immunity, antimicrobial, anti-inflammatory and immunomodulatory functions. It has been suggested a possible association between vitamin D deficiency and increased risk and length of respiratory infections in patients with common variable immunodeficiency (CVID). METHODS: We conducted a descriptive study in patients with CVID. Vitamin D serum levels were measured in all patients. The results were analyzed using descriptive statistics by calculating measures of dispersion and central tendency. RESULTS: We studied 20 patients, 13 women and 7 males, with an age average of 37 ± 13.43 years. The mean concentration of vitamin D in patients was 15.43 ng/mL ± 7.23. Thirty percent of all patients had severe Vitamin D deficiency, 45% had mild to moderate deficiency and 25% had insufficiency. Autoimmune diseases were associated in 35% of CVID patients, 42.8% of them had severe vitamin D deficiency. In patients with bronchiectasis, 85% were found with vitamin D deficiency, and it was severe in 35.2%. 41% of patients with bronchiectasis were classified as severe on the Bhalla score of severity, 57% of these patients had severe deficiency and 14.2% mild-moderate deficiency. CONCLUSIONS: : We found deficiency of vitamin D in patients with CVID patients. Most of patients with CVID and bronchiectasis were detected with mild to severe vitamin D deficiency. Almost the half of patients with autoimmune diseases associated to CVID showed deficiency of vitamin D. We recommend to investigate the association of vitamin D deficiency on patients with immunodeficiencies.

[Quality of life in adults with variable common immunodeficiency and bronchiectasis]. / Calidad de vida en adultos con inmunodeficiencias común variable y bronquiectasias.

BACKGROUND: Common variable immunodeficiency (CVID) is a primary immunodeficiency characterized by hypogammaglobulinemia. Its prevalence is 1:10000 to 1:50000 with the highest incidence in children, 6 to 10 years, and in adults around age 29. The association of CVID and bronchiectasis has a prevalence of 17-90%. The quality of life in these patients can be assessed through instruments such as the Saint George Respiratory Questionnaire (SGRQ), which is designed for patients with chronic lung diseases and validated for the Mexican population. OBJECTIVE: [corrected] To evaluate the quality of life in adult patients with CVID and bronchiectasis using the SGRQ. METHODS: We applied CRSG to all the patients of the Immunodeficiencies Clinic from Hospital Especialidades CMN SXXI diagnosed with CVID and bronchiectasis for assessing quality of life which was evaluated in the three areas of application 1)Symptoms, 2)Activities and 3)Impact and the overall quality of life. We also analyzed its relationship with the severity of bronchiectasis confirmed by HRCT. RESULTS: 19 patients were included, (5 males, 14 women) in whom it was found affected the overall quality of life in 84.2%. Women showed higher scores for all areas of the SGRQ (♀ 28.3 ± 25.18 vs. ♂ 9.89 ± 8.14). The most affected area by both sexes was the Symptoms in 92% of women and 80% men. About the severity of bronchiectasis patients with mild bronquietasias presented scores 0-22.2 (x= 11.1 ± 15.6), those with moderate bronchiectasis 3.24-56.9 (x=25.5 ± 21.76) and severe with scores of 0-74.8 (x= 24.1 ± 28.5.). CONCLUSIONS: Patients with CVID and bronchiectasis have impaired quality of life, mainly associated with respiratory symptoms, with less involvement of and impact areas. Females were most affected in intensity to show higher scores.

[Autoimmune hematologic diseases in adult patients with common variable immunodeficiency]. / Enfermedades hematológicas autoinmunes en adultos con inmunodeficiencia com˙n variable.

BACKGROUND: Common variable immunodeficiency (CVID) is a primary immunodeficiency characterized by defective immunoglobulin production. Twenty percent of patients may also have associated autoimmune diseases, especially hematologic, whose prevalence is estimated at 5 to 8%. OBJECTIVE: To report the occurrence of autoimmune haematological disorders in CVID adults. METHODS: We included 18 patients with CVID, who underwent hematologic evaluation, which included: CBC, serum folate or vitamin B complex and bone marrow aspirate. RESULTS: Of a total of 18 patients, 11 women (61%), mean age 38 ± 13.5, six patients (33.3%) had autoimmune diseases, five of them had blood diseases (4 with PTI and one with Evans syndrome). Three patients had more than one autoimmune disease and one presented three autoimmune diseases (Evans syndrome, hypoparathyroidism and celiac disease with a history of autoimmune hemolytic anemia). CONCLUSIONS: The prevalence of autoimmune diseases in this group of patients with CVID was higher than the 20% reported in the literature. Hematological diseases should be suspected in CVID patients, since half of our cases presented them.