Late-onset mitochondrial encephalopathy with lactic acidosis and stroke-like episodes and the role of serial imaging.

Mitochondria are essential for human metabolic function. Over 350 genetic mutations are associated with mitochondrial diseases, which are inherited in a matrilineal fashion. In mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS), defective mitochondrial function and resultant impaired cellular energy production compromise vascular perfusion in affected tissues. Early diagnostic criteria suggested the diagnosis should be considered in those under 40. However, a broader range of phenotypes are now recognised, including those that present for the first time later in life. The primary presenting feature in MELAS is a stroke-like episode invariably resulting in patients undergoing neuroradiological imaging. We present a case of a woman with a first presentation of a stroke-like episode and seizures in her 40s who was eventually diagnosed with MELAS. We detail her clinical presentation, treatment and diagnosis, emphasising the role of serial imaging in her diagnosis.

Pericarditis of Polyarteritis Nodosa.

Polyarteritis nodosa (PAN) is a rare systemic vasculitis characterised by necrotising inflammation of medium-sized arteries. PAN can affect patients of any age, gender, or ethnic background. Its highest incidence is in the fifth-sixth decade of life, with a slight male-to-female predilection. PAN can be idiopathic or secondary to a multitude of systemic conditions, such as infection, haematological malignancy, or autoinflammatory disorders. PAN has a broad spectrum of possible clinical manifestations the most common being constitutional symptoms, such as fever and myalgia. While cardiac involvement is well-described and is a common cause of mortality, it is exceedingly uncommon as the initial presentation. Below, we describe a case of a female in her 60s who presented with pericarditis as the first manifestation of PAN.

The Effects of Exercise on Coronary Collateral Circulation: A Review.

The effects of exercise on the cardiovascular system are multifaceted and complex. It is well-documented that exercise can reduce mortality related to cardiovascular pathology. One anatomical structure that has been implicated in this process is the coronary collateral circulation. The goal of this review is to evaluate the current literature on the effects of exercise on human coronary collateral circulation. A search for literature was conducted on the databases Science Direct and PubMed using the terms: coronary collateral, collateral, exercise, physical activity, resistance training, endurance training, and collateral artery. Research that had the primary outcome of assessing human coronary collateralization secondary to exercise was included. Research in which the effect of exercise was not the primary outcome was excluded. As a result, a total of 13 research papers on the effects of exercise on coronary collateral circulation were included. Thirteen original research papers were reviewed. The mean age range in all studies was between 48 and 64 years old. There was a predominance of male participants, with a total of 597 male patients and 108 female patients across all studies. It was found that initial research underestimated the effect of exercise on coronary collateral circulation due to a lack of sensitive assessment methods. With the introduction of sensitive measures like the collateral flow index (CFI) and Rentrop scoring, results have shown that coronary collateral function can be increased with exercise. Exercise has been shown to enhance coronary collateral function. There is limited evidence as to which type, duration, or intensity of exercise is most favourable to enhance coronary collateral function. There is also relatively little data on the effects of exercise in the female population and those over the age of 65 years. More research is required to determine the specific effects of exercise on coronary collateral circulation in various age groups, genders, co-morbidities, specific exercise modalities, durations, intensities, and the effect of pharmacotherapy.