1.
Org Lett
; 17(11): 2836-9, 2015 Jun 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25997669
RESUMO
2-Deoxy-2-fluoroglycosyl iodides are privileged glycosyl donors for the stereoselective preparation of 1-Nu-ß-fluorosugars, which are useful reagents for chemical site-selective protein glycosylation. Ready access to such ß-fluorosugars enables the mild and efficient construction of well-defined fluoroglycoproteins.
Assuntos
Glicoproteínas/síntese química , Glicosídeos/síntese química , Hidrocarbonetos Fluorados/química , Indicadores e Reagentes/química , Glicoproteínas/química , Glicosídeos/química , Glicosilação , Estrutura Molecular
2.
Chem Commun (Camb)
; 51(25): 5250-2, 2015 Mar 28.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25415185
RESUMO
We have developed a strategy for selective imaging of collagen in live foetal ovine osteoblasts. Our approach involves the incorporation of an azide-tagged proline in the biosynthesis of collagen followed by labelling using a strain-promoted [3+2] azide-alkyne cycloaddition reaction.