RESUMO
We describe the inline integration of the digital holographic sensor HoloTop in a precision turning plant. A fully automated part-handling system that fulfills the requirements for cycle time and stability was built and integrated into the production process. The inspection system has been running in multishift operation since 2015. For the first time, to the best of our knowledge, the results of one-year, long-term height measurements of 10 million parts under rough production conditions are presented to verify the suitability for industrial use.
RESUMO
The sodium hydride mediated cyclization of arylacetonitriles with oxalic acid bis(imidoyl) dichlorides, aza-analogues of oxalyl chloride, afforded functionalized 2-alkylidene-3-iminoindoles with very good regio- and E/Z selectivity. Excellent chemoselectivities were observed for functionalized substrates. Based on these results a domino "cyclization-lactamization" reaction of bis(imidoyl) chlorides with methyl 2-(cyanomethyl)benzoate was developed. This process allowed a convenient one-pot synthesis of indolo[1,2-b]isoquinolin-5-ones related to tryptanthrin. A new and convenient synthesis of delta-carbolines by intramolecular electrocyclization-elimination reactions of 2-alkylidene-3-iminoindoles was developed. It was shown that delta-carbolines selectively bind to triplex or duplex DNA (intercalation). Indirubine analogues were prepared by deprotection and lactonization of functionalized 2-alkylidene-3-iminoindoles.