RESUMO
Juvenile dermatomyositis (JDM) is the leading cause of chronic idiopathic inflammatory myopathy of auto-immune origin in children. Seven patients with JDM found in the records from 1998-2019 of the Department of Dermatology Farhat Hached Hospital, Sousse, Tunisia. Our study concerned a total of six girls and one boy with a median age at disease onset of 8,16 years. The average time before diagnosis was 8,8 months. The onset of the disease was acute in 2 patients. All patients displayed skin manifestations at diagnosis, with proximal muscular weakness in 4 cases. Four patients had elevated muscle enzymes and all of them showed myopathic findings on electromyography. Oral corticosteroids were prescribed in 6 patients, in association with other systemic therapies. Three patients achieved a good outcome while two others relapsed. The two other patients showed corticosteroids resistance with a fatal outcome in one case. This study highlights the diagnostic features and management of juvenile dermatomyositis.
Assuntos
Dermatomiosite , Humanos , Dermatomiosite/diagnóstico , Dermatomiosite/tratamento farmacológico , Masculino , Feminino , Criança , Adolescente , Pré-Escolar , Corticosteroides/uso terapêutico , Estudos Retrospectivos , Eletromiografia , Tunísia , Glucocorticoides/uso terapêutico , Glucocorticoides/administração & dosagemAssuntos
Antiprotozoários , Cardiomiopatia Dilatada , Leishmaniose Cutânea , Compostos Organometálicos , Humanos , Antimoniato de Meglumina/efeitos adversos , Cardiomiopatia Dilatada/induzido quimicamente , Cardiomiopatia Dilatada/tratamento farmacológico , Meglumina/efeitos adversos , Leishmaniose Cutânea/diagnóstico , Leishmaniose Cutânea/tratamento farmacológicoRESUMO
Chemotherapy extravasation is a rare but severe cutaneous complication associated with administration of intravenous chemotherapy. Extravasation causes serious disability and diminishes the quality of life in patients with cancer undergoing antineoplastic therapy. Treatment of chemotherapy extravasation is not standardized. We report a patient with paclitaxel extravasation who was successfully treated with corticosteroids.
Assuntos
Antineoplásicos Fitogênicos , Paclitaxel , Humanos , Paclitaxel/efeitos adversos , Antineoplásicos Fitogênicos/efeitos adversos , Qualidade de Vida , Extravasamento de Materiais Terapêuticos e Diagnósticos , PeleRESUMO
Pemphigus herpetiformis (PH) is a rare form of pemphigus, especially when occurring in childhood. Misdiagnosis is common in this age group. The disease exhibits diverse clinical and histological aspects. Further immunological investigations should be performed in order to make the right diagnosis with a correct management strategy.
Assuntos
Hidradenite Supurativa , Policondrite Recidivante , Hidradenite Supurativa/complicações , Hidradenite Supurativa/diagnóstico , Hidradenite Supurativa/tratamento farmacológico , Humanos , Policondrite Recidivante/complicações , Policondrite Recidivante/diagnóstico , Policondrite Recidivante/tratamento farmacológicoAssuntos
Infecções por Vírus Epstein-Barr , Linfoma Cutâneo de Células T , Neoplasias Cutâneas , Infecções por Vírus Epstein-Barr/patologia , Humanos , Células Matadoras Naturais/patologia , Linfoma Cutâneo de Células T/diagnóstico , Linfoma Cutâneo de Células T/patologia , Neoplasias Cutâneas/patologia , ÚlceraAssuntos
Exantema , Pitiríase Liquenoide , Criança , Exantema/diagnóstico , Exantema/etiologia , Humanos , NecroseAssuntos
Neoplasias da Mama/complicações , Esclerodermia Localizada/classificação , Biomarcadores/análise , Biomarcadores/sangue , Neoplasias da Mama/diagnóstico , Tratamento Farmacológico/métodos , Feminino , Fator de Transcrição GATA3/análise , Fator de Transcrição GATA3/sangue , Humanos , Queratina-7/análise , Queratina-7/sangue , Pessoa de Meia-Idade , Cuidados Paliativos/métodos , Esclerodermia Localizada/etiologiaRESUMO
Skin manifestations of sarcoidosis occur in up to 30% of cases, and may be the sentinel sign of the disease, with the skin being sometimes exclusively affected. While this may facilitate an early dermatologic diagnosis, heterogeneity in the cutaneous morphologies of sarcoidosis complicates recognition and affirms its reputation as a "great imitator". Here, we present a case of a verrucous version of sarcoidosis that may be misdiagnosed because it can mimic other inflammatory and neoplastic skin disorders. Although it is a rare variant, its presence should alert clinicians to the likelihood of systemic involvement of cutaneous sarcoidosis.