[Possible role of autophagy activation in the stimulation of regeneration].

Human cell senescence occurs unevenly and senescent cells in tissues frequently can disturb the function of neighbouring nonsenescent ones. Setting of tissues regeneration can have profound practical significance in medicine, especially in geriatrics. One of the approaches to solve the problem is selective elimination of senescent and damaged cells from the tissues that can be the first phase of the process. During the investigation of the mechanisms of action of the preparation for hair growth stimulation it was discovered that this preparation does not stimulate proliferation of various human cells and does not increase the resistance of cells to stress. On the contrary the preparation becomes cytotoxic at the conditions of oxidative stress although on its own account it did not induce elevation of production of reactive oxygen species. Further investigations showed that the preparation increases transcriptional activity of p53 gene, increase autophagy level and induce weak adipogenic differentiation. The hypothesis of autophagic regeneration is discussed. As a result, the selective autophagic cell death of any senescent and damaged cells that undergoes oxidative stress triggers the regeneration process which can be increased by both the rejuvenation effect of increased autophagy and at the expense of nutrients released during the autophagy.

[Methodical aspects of formation of diagnostically related groups for inpatient therapeutic-prophylactic institutions]. / Metodicheskie aspekty razrabotki diagnosticheski sviazannykh grupp dlia statsionarov lechebno-profilakticheskikh uchrezhdenii.

The authors discuss problems concerning the methodology of the evolution of standard sets of therapeutic-prophylactic measures and diagnostically related groups (DRG) for in-patient hospitals. The peculiarities of the formation of DRG for colo-proctological patients in a proctological clinic are shown as an example and DRG of the surgical and therapeutic classes are indicated. The results of studying the frequency of combined pathology in diseases of the large intestine are discussed.

[Evaluation of the technology of health care delivery under new economics]. / K voprosu ob otsenke tekhnologii okazaniia meditsinskoi pomoshchi v novykh usloviiakh khoziaistvovaniia.

The development and improvement of technology in health care delivery and its utilization in applied public health is a prerequisite for improving the quality of curative and diagnostic process, rational use of material and technical resources and medical personnel of curative and preventive establishments under new economic methods of public health management. The volume standards of health care delivery comprising the standard, optimum sets of measures for patients including the list of diagnostic and treatment procedures can be considered as the main instrument and the major criteria in evaluating the completeness and quality of health care delivery at hospital stage and at different regional levels.