Computerized evaluation scheme to detect metastasis in sentinel lymph nodes using contrast-enhanced computed tomography before breast cancer surgery.

Sentinel lymph node (SLN) biopsy for evaluating lymph node metastasis during breast cancer surgery is associated with several problems, such as the consequent increase in operation time and the possibility of abrupt changes in the treatment plan during the operation. Although it is desirable to distinguish SLNs with and without cancer metastasis before surgery, there is no established examination for this purpose. This study aimed to develop a computerized scheme for evaluating metastasis in SLNs by analyzing computed tomography lymphography images and the three-dimensional versions of these images. Our database consisted of computed tomography lymphography images from 100 patients with breast cancer. Three subjective features of the nodes were assessed in the three-dimensional images: (1) the shape of the lymphoduct, (2) degree of signal enhancement in the nodes, and (3) shape of the nodes. Six objective features were also assessed in the computed tomography lymphography images: (4) the long axis, (5) area, (6) standard deviation of the signal values, (7) mean signal values, (8) maximum signal value, and (9) minimum signal value. Support vector machines were employed to evaluate cancer metastasis in SLNs. For the input, six of the nine features were selected in a stepwise method. The classification accuracy, sensitivity, and specificity were 98.0% (98/100), 97.8% (44/45), and 98.2% (54/55), respectively. The positive and negative predictive values were 97.8% (44/45) and 98.2% (54/55), respectively. This computerized method exhibited high classification accuracy and will be useful in determining the need for lymph node dissection before breast cancer surgery.

A New Suturing Device for Small Arteries.

Endoscope-assisted surgery and robot-assisted surgery are not common in cardiac surgery, particularly coronary artery bypass grafting, because of the complex nature of the procedures. We developed a new suturing device that allows for easy performance of such cardiac surgeries in comparison with conventional suturing methods. A total of 63 rabbits were used in this study. The right carotid artery was bypassed using the same side of the jugular vein under endoscopic guidance. Of these, 48 rabbits were operated on using the new devices and 15 rabbits were operated on using conventional polypropylene sutures. The proximal suturing time was 16.6 ± 5.3 minutes in the group that underwent surgery using the new device (group D) and 22.8 ± 7.6 minutes in the control group (group C; P < 0.05). The distal suture time was 16.3 ± 4.2 minutes in group D and 22.8 ± 6.0 minutes in group C (P < 0.05). The operation time was 113.0 ± 15.8 minutes in group D and 136.7 ± 20.6 minutes in group C (P < 0.05). Graft flow was 19.9 ± 12.8 mL/minute in group D and 12.1 ± 11.3 mL/minute in group C (P < 0.05). Thus, the operation time and the suture time differed significantly between the groups. This device provides advantages in endoscopic surgery compared to the conventional suture method.