Protein Carbonylation in Patients with Myelodysplastic Syndrome: An Opportunity for Deferasirox Therapy.

Control of oxidative stress in the bone marrow (BM) is key for maintaining the interplay between self-renewal, proliferation, and differentiation of hematopoietic cells. Breakdown of this regulation can lead to diseases characterized by BM failure such as the myelodysplastic syndromes (MDS). To better understand the role of oxidative stress in MDS development, we compared protein carbonylation as an indicator of oxidative stress in the BM of patients with MDS and control subjects, and also patients with MDS under treatment with the iron chelator deferasirox (DFX). As expected, differences in the pattern of protein carbonylation were observed in BM samples between MDS patients and controls, with an increase in protein carbonylation in the former. Strikingly, patients under DFX treatment had lower levels of protein carbonylation in BM with respect to untreated patients. Proteomic analysis identified four proteins with high carbonylation levels in MDS BM cells. Finally, as oxidative stress-related signaling pathways can modulate the cell cycle through p53, we analyzed the expression of the p53 target gene p21 in BM cells, finding that it was significantly upregulated in patients with MDS and was significantly downregulated after DFX treatment. Overall, our results suggest that the fine-tuning of oxidative stress levels in the BM of patients with MDS might control malignant progression.

Sobredentaduras, una opción terapéutica: reporte de un caso clínico / Ovendentures, a therapeutic option: report of a clinical case

El objetivo de este artículo es dar a conocer el uso de las sobredentaduras como una opción de tratamiento en el paciente parcial o totalmente desdentado. La idea de dejar restos aislados de raíces o colocar implantes en los maxilares y de construir prótesis sobre ellos tiene más de 100 años de antigüedad. La utilización de aditamentos en sobredentaduras aumenta la retención y la estabilidad y es de gran ayuda en pacientes con poco reborde residual o que presenten problemas de adaptación a la prótesis por desalojo constante. Se colocaron 4 aditamentos de precisión Dalla-bona (IMTEC Corp.), 2 para implantes en el maxilar y 2 radiculares en la mandíbula, teniendo los primeros una desventaja: el precio. Los aditamentos se colocaan en el modelo antes del enmuflado, segurándose de activar el anillo plástico antes de colocar la resina acrílica. El uso de sobredentaduras en el tratamiento de pacientes parcial o totalmente desdentados mantiene el procentaje del nivel óseo, disminuyendo o incluso deteniendo el grado de atrofia alveolar