RESUMO
Lidocaine has been shown to have adverse effects on mouse oocyte fertilization and embryo development. We have demonstrated the presence of pharmacologic levels of lidocaine in human serum and follicular fluid obtained during ultrasound guided transvaginal oocyte retrieval. The significance of this finding is unclear, as four of the eight patients studied became pregnant, including the patient with the highest follicular fluid lidocaine levels. Further evaluation of the effect of lidocaine on human embryos is warranted.
Assuntos
Líquido Folicular/análise , Lidocaína/análise , Oócitos/citologia , Anestesia Local , Separação Celular/métodos , Feminino , Fertilização in vitro/métodos , Humanos , Lidocaína/efeitos adversos , Lidocaína/farmacologia , Oócitos/efeitos dos fármacosRESUMO
Prompt evaluation should be carried out for any adolescent complaining of excessive hair growth. The workup should be directed toward the exclusion of androgen secreting neoplasms and correctable adrenal pathology. A minimal workup must include total serum testosterone, DHEA-S, and prolactin. The clinician must then determine if further testing will alter management substantially. Treatment includes removal or neutralization of any discrete source of serum androgens, normalization of altered steroid physiology, and cosmetic correction (electrolysis) of existing hair growth. Successful management will allow normal socialization of the young woman afflicted with this distressing condition.