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Sci Transl Med ; 11(483)2019 03 13.
Artigo em Inglês | MEDLINE | ID: mdl-30867322

RESUMO

Multigram drug depot systems for extended drug release could transform our capacity to effectively treat patients across a myriad of diseases. For example, tuberculosis (TB) requires multimonth courses of daily multigram doses for treatment. To address the challenge of prolonged dosing for regimens requiring multigram drug dosing, we developed a gastric resident system delivered through the nasogastric route that was capable of safely encapsulating and releasing grams of antibiotics over a period of weeks. Initial preclinical safety and drug release were demonstrated in a swine model with a panel of TB antibiotics. We anticipate multiple applications in the field of infectious diseases, as well as for other indications where multigram depots could impart meaningful benefits to patients, helping maximize adherence to their medication.


Assuntos
Antituberculosos/uso terapêutico , Sistemas de Liberação de Medicamentos , Estômago/efeitos dos fármacos , Tuberculose/tratamento farmacológico , Animais , Antibacterianos/uso terapêutico , Antituberculosos/farmacologia , Preparações de Ação Retardada , Relação Dose-Resposta a Droga , Doxiciclina/uso terapêutico , Sistemas de Liberação de Medicamentos/economia , Liberação Controlada de Fármacos , Humanos , Suínos
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