Infant Sleep Hazards and the Risk of Sudden Unexpected Death in Infancy.

OBJECTIVE: To examine the effects of infant sofa-sleeping, recent use by caregivers of alcohol, cannabis, and/or other drugs, and bed type and pillows, on the risk of sudden unexpected death in infancy (SUDI) in New Zealand. STUDY DESIGN: A nationwide prospective case-control study was implemented between March 2012 and February 2015. Data were collected during interviews with parents/caregivers. "Hazards" were defined as infant exposure to 1 or more of sofa-sleeping and recent use by caregivers of alcohol, cannabis, and other drugs. The interaction of hazards with tobacco smoking in pregnancy and bed sharing, including for very young infants, and the difference in risk for Maori and non-Maori infants, also were assessed. RESULTS: The study enrolled 132 cases and 258 controls. SUDI risk increased with infant sofa-sleeping (imputed aOR [IaOR] 24.22, 95% CI 1.65-356.40) and with hazards (IaOR 3.35, 95% CI 1.40-8.01). The SUDI risk from the combination of tobacco smoking in pregnancy and bed sharing (IaOR 29.0, 95% CI 10.10-83.33) increased with the addition of 1 or more hazards (IaOR 148.24, 95% CI 15.72-1398), and infants younger than 3 months appeared to be at greater risk (IaOR 450.61, 95% CI 26.84-7593.14). CONCLUSIONS: Tobacco smoking in pregnancy and bed sharing remain the greatest SUDI risks for infants and risk increases further in the presence of sofa-sleeping or recent caregiver use of alcohol and/or cannabis and other drugs. Continued implementation of effective, appropriate programs for smoking cessation, safe sleep, and supplying safe sleep beds is required to reduce New Zealand SUDI rates and SUDI disparity among Maori.

Related plants tend to share pollinators and herbivores, but strength of phylogenetic signal varies among plant families.

Related plants are often hypothesized to interact with similar sets of pollinators and herbivores, but this idea has only mixed empirical support. This may be because plant families vary in their tendency to share interaction partners. We quantify overlap of interaction partners for all pairs of plants in 59 pollination and 11 herbivory networks based on the numbers of shared and unshared interaction partners (thereby capturing both proportional and absolute overlap). We test for relationships between phylogenetic distance and partner overlap within each network; whether these relationships varied with the composition of the plant community; and whether well-represented plant families showed different relationships. Across all networks, more closely related plants tended to have greater overlap. The strength of this relationship within a network was unrelated to the composition of the network's plant component, but, when considered separately, different plant families showed different relationships between phylogenetic distance and overlap of interaction partners. The variety of relationships between phylogenetic distance and partner overlap in different plant families probably reflects a comparable variety of ecological and evolutionary processes. Considering factors affecting particular species-rich groups within a community could be the key to understanding the distribution of interactions at the network level.

Color perception impairment following optic neuritis and its association with retinal atrophy.

BACKGROUND: Emphasis is often placed on the good recovery of vision following optic neuritis (ON). However, patients continue to perceive difficulties in performing everyday visual tasks and have reduced visual quality of life. This is in addition to documented permanent loss of retinal volume. METHODS: Seventy-five subjects following monocular ON (> 3 months prior to assessment), were evaluated by the Rabin cone contrast test (CCT). Red, green and blue cone contrast scores were extracted for the affected and fellow eyes. Retinal nerve fiber layer (RNFL) and macular volume (MV) were assessed using optical coherence tomography. RESULTS: Fifty-seven patients had multiple sclerosis and 17 had clinically isolated syndrome. Median time from ON to evaluation was 47 months. Expanded Disability Status Scale (EDSS) ranged between 0 and 6.5 with average of 2 ± 1.3. Cone contrast scores for red, green and blue in the affected eyes were significantly lower than in the fellow eyes. RNFL thickness and MV were reduced in the affected compared to the fellow eyes. Positive correlations between CCT and RNFL were found in both eyes, but much stronger in the affected eyes (r = 0.72, 0.74, 0.5 and 0.53, 0.58, 0.46 for red green and blue in each eye, respectively). Positive correlations between CCT and MV were found in both eyes, but only modestly stronger in the affected eyes. CONCLUSIONS: Impaired chromatic discrimination thresholds quantitatively document persistent functional complaints after ON. There is evidence of dysfunction in both the affected eye and the fellow eye.

Development of an X-ray imaging system to prevent scintillator degradation for white synchrotron radiation.

The high flux of the white X-ray beams from third-generation synchrotron light sources can significantly benefit the development of high-speed X-ray imaging, but can also bring technical challenges to existing X-ray imaging systems. One prevalent problem is that the image quality deteriorates because of dust particles accumulating on the scintillator screen during exposure to intense X-ray radiation. Here, this problem has been solved by embedding the scintillator in a flowing inert-gas environment. It is also shown that the detector maintains the quality of the captured images even after days of X-ray exposure. This modification is cost-efficient and easy to implement. Representative examples of applications using the X-ray imaging system are also provided, including fast tomography and multimodal phase-contrast imaging for biomedical and geological samples.

The combination of bed sharing and maternal smoking leads to a greatly increased risk of sudden unexpected death in infancy: the New Zealand SUDI Nationwide Case Control Study.

BACKGROUND: Despite a major reduction in overall infant mortality, sudden unexpected death in infancy (SUDI) continues to be of concern in New Zealand, as the rate is high by international standards, and is even higher in indigenous Maori. AIM: To identify modifiable risk factors for SUDI. METHODS: A three-year (1 March 2012-28 February 2015) nationwide case-control study was conducted in New Zealand. RESULTS: There were 137 SUDI cases, giving a SUDI mortality rate of 0.76/1,000 live births. The rate for Maori was 1.41/1,000, Pacific 1.01/1,000 and non-Maori non-Pacific (predominantly European) 0.50/1,000. The parent(s) of 97% of the SUDI cases were interviewed. Six hundred and forty-nine controls were selected and 258 (40%) were interviewed. The two major risk factors for SUDI were: maternal smoking in pregnancy (adjusted OR=6.01, 95% CI=2.97, 12.15) and bed sharing (aOR=4.96, 95% CI=2.55, 9.64). There was a significant interaction (p=0.002) between bed sharing and antenatal maternal smoking. Infants exposed to both risk factors had a markedly increased risk of SUDI (aOR=32.8, 95% CI=11.2, 95.8) compared with infants not exposed to either risk factor. Infants not sharing the parental bedroom were also at increased risk of SUDI (aOR=2.77, 95% CI=1.45, 5.30). Just 21 cases over the three-year study were not exposed to smoking in pregnancy, bed sharing or front or side sleeping position. CONCLUSIONS: This study has shown that many of the risk factors that were identified in the original New Zealand Cot Death Study (1987-1989) are still relevant today. The combination of maternal smoking in pregnancy and bed sharing is extremely hazardous for infants. Furthermore, our findings indicate that the SUDI prevention messages are still applicable today and should be reinforced. SUDI mortality could be reduced to just seven p.a. in New Zealand (approximately one in 10,000 live births).

Infant suffocation in place of sleep: New Zealand national data 2002-2009.

BACKGROUND: Accidental suffocation during sleep, leading to death, has been described as due to overlay or wedging of infants, particularly in a bed-sharing situation. Bed sharing is a risk factor for sudden infant death syndrome but the mechanism of death is not clearly defined. Accidental suffocation may be one such mechanism. OBJECTIVE: To describe accidental suffocation deaths during sleep in New Zealand between 2002 and 2009. DESIGN: The New Zealand mortality database, which holds data collected by the Child Youth Mortality Review Committee and the Perinatal and Maternal Mortality Review Committee, was searched for potential deaths by accidental suffocation in infants less than 1 year of age. Deaths underwent a detailed analysis by demographic data and qualitative report. RESULTS: There were 48 deaths due to accidental suffocation between 2002 and 2009 in New Zealand, equating to a rate of 0.10 deaths per 1000 live births. The most common age at death was 1 month or under (n=11, 23%). Deaths were due to overlay (n=30, 63%) or wedging (n=18, 37%) and two-thirds (n=34, 71%) were in a bed-sharing situation. A quarter of deaths (n=12, 25%) occurred in makeshift bedding arrangements, some of which were away from home. CONCLUSIONS: Accidental suffocation in bed was responsible for 48 preventable deaths. Prevention of these accidental deaths needs to focus on supporting changes in family behaviour with safety messages that are consistent, persistent and disseminated widely.

A meta-analysis of the effects of pesticides and fertilizers on survival and growth of amphibians.

The input of agrochemicals has contributed to alteration of community composition in managed and associated natural systems, including amphibian biodiversity. Pesticides and fertilizers negatively affect many amphibian species and can cause mortality and sublethal effects, such as reduced growth and increased susceptibility to disease. However, the effect of pesticides and fertilizers varies among amphibian species. We used meta-analytic techniques to quantify the lethal and sublethal effects of pesticides and fertilizers on amphibians in an effort to review the published work to date and produce generalized conclusions. We found that pesticides and fertilizers had a negative effect on survival of -0.9027 and growth of -0.0737 across all reported amphibian species. We also observed differences between chemical classes in their impact on amphibians: inorganic fertilizers, organophosphates, chloropyridinyl, phosphonoglycines, carbamates, and triazines negatively affected amphibian survival, while organophosphates and phosphonoglycines negatively affected amphibian growth. Our results suggest that pesticides and fertilizers are an important stressor for amphibians in agriculturally dominated systems. Furthermore, certain chemical classes are more likely to harm amphibians. Best management practices in agroecosystems should incorporate amphibian species-specific response to agrochemicals as well as life stage dependent susceptibility to best conserve amphibian biodiversity in these landscapes.

A meta-analysis of the effects of ultraviolet B radiation and its synergistic interactions with pH, contaminants, and disease on amphibian survival.

Human alterations to natural systems have resulted in a loss of biological diversity around the world. Amphibian population losses have been more severe than those of birds and mammals. Amphibian population declines are likely due to many factors including habitat loss, disease, contaminants, introduced species and ultraviolet-B (UVB) radiation. The effect of UVB, however, varies widely among species and can vary within populations of the same species or at different life-history stages. This variation has often led to opposing conclusions about how UVB affects amphibians. We used meta-analysis techniques to explore the overall effects of UVB radiation on survival in amphibians. We also used recently developed factorial meta-analytic techniques to quantify potential interactions between UVB radiation and other stressors on amphibians. Ultraviolet-B radiation reduced survival of amphibians by 1.9-fold compared with shielded controls. Larvae were more susceptible to damage from UVB radiation compared with embryos, and salamanders were more susceptible compared with frogs and toads. Furthermore, UVB radiation interacted synergistically with other environmental stressors and resulted in greater than additive effects on survival when 2 stressors were present. Our results suggest that UVB radiation is an important stressor in amphibians, particularly in light of potential synergisms between UVB and other stressors in amphibian habitats.

Effects of UVB radiation on marine and freshwater organisms: a synthesis through meta-analysis.

Ultraviolet-B (UVB) radiation is a global stressor with potentially far-reaching ecological impacts. In the first quantitative analysis of the effects of UVB on aquatic organisms, we used meta-analytic techniques to explore the effects of UVB on survival and growth in freshwater and marine systems. Based on the large body of literature on the effects of UVB in aquatic systems, we predicted that UVB would have different effects in different habitats, experimental venues, trophic groups and life history stages. Contrary to our predictions, we found an overall negative effect of UVB on both survival and growth that crossed life histories, trophic groups, habitats and experimental venues. UVB had larger negative effects on growth in embryos compared with later life history stages. Despite the overall negative effect of UVB, effect sizes varied widely. In the survival analyses, no relationship between mean effect size and taxonomic groups or levels of exposure to UVB was detected. In the growth analyses, a larger negative effect on protozoans was observed. Our analyses suggest that the effects of UVB in aquatic systems are large and negative but highly variable between organisms. Variation in susceptibility may have important implications for population and community structure.