1.
Bioorg Med Chem Lett
; 21(14): 4215-9, 2011 Jul 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21669521
RESUMO
Directed screening has identified a novel series of MMP13 inhibitors that possess good levels of activity whilst possessing excellent selectivity over related MMPs. The binding mode of the series has been solved by co-crystallisation and demonstrates an interesting mode of inhibition without interaction with the catalytic zinc atom.