1.
Org Lett
; 23(24): 9505-9509, 2021 Dec 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34844411
RESUMO
Aminocarbonylation of alkenyl iodides with CO and amines proceeded under heating to produce α,ß-unsaturated amides in good yields (23 examples, 71% average yield). This catalyst-free method exhibited good functional-group tolerance, and open a straightforward access to functionalized acrylamides, as illustrated by the synthesis of Ilepcimide. A hybrid radical/ionic mechanism involving chain electron transfer is proposed for this transformation.