Bio-inspired microfluidics: A review.

Biomicrofluidics, a subdomain of microfluidics, has been inspired by several ideas from nature. However, while the basic inspiration for the same may be drawn from the living world, the translation of all relevant essential functionalities to an artificially engineered framework does not remain trivial. Here, we review the recent progress in bio-inspired microfluidic systems via harnessing the integration of experimental and simulation tools delving into the interface of engineering and biology. Development of "on-chip" technologies as well as their multifarious applications is subsequently discussed, accompanying the relevant advancements in materials and fabrication technology. Pointers toward new directions in research, including an amalgamated fusion of data-driven modeling (such as artificial intelligence and machine learning) and physics-based paradigm, to come up with a human physiological replica on a synthetic bio-chip with due accounting of personalized features, are suggested. These are likely to facilitate physiologically replicating disease modeling on an artificially engineered biochip as well as advance drug development and screening in an expedited route with the minimization of animal and human trials.

Damped Oscillatory Dynamics of a Drop Impacting over Oil-Infused Slippery Interfaces─Does the Oil Viscosity Slow it Down?

A liquid drop impacting on a soft surface is known to exhibit fascinating dynamics that is distinctive from its bounce-back atop a rigid surface. However, while the early spreading of the drop subsequent to its immediate impact with a lubricating liquid layer appears to be reasonably well understood, the later events of retraction and eventual stabilization appear to be poorly addressed. Here, we bring out the nontrivial confluence of the solid substrate wettability and the liquid layer viscosity toward modulating the post-collision dynamics of an impinging liquid drop on a viscous oil-infused surface during its later phase of settlement before arriving at an equilibrium state. Our results reveal that despite an intuitive analogy with the classical phenomenon of damped oscillation, the drop, during its later stages of motion, undergoes dynamical events that may be nontrivially dictated by not only the relative viscosity of the impacting drop and the liquid layer but also the intrinsic wettability of the solid substrate, governing its post-impact settlement via a sequel of spreading-retraction cycles. As a consequence, the viscous liquid layer, instead of providing additional damping, may nonintuitively reduce the effective viscous dissipation so as to hasten the drop's final settlement. These results may turn out to be critical in designing engineered surfaces for tuning the movement of drops in a preferential pathway, bearing decisive implications in the functionalities of liquid lenses, inkjet printing, spray coating and cooling, and several other emerging applications in the realm of lubricated fluidic interfaces.

Droplet Impact Dynamics on Biomimetic Replica of Yellow Rose Petals: Rebound to Micropinning Transition.

Rose petals exhibit a phenomenal wetting property of being sticky and superhydrophobic simultaneously. A recent study has shown that for short timescales, associated with drop impact phenomenon, lotus leaf and rose petal replicas exhibit similar wettability, thereby highlighting the difference between long and short time wettability. Also, short time wetting on rose petals of different colors remains completely unaddressed, as almost all existing study on wetting of rose petals have been performed with the classical red rose (Rosa chinensis). In this paper, we compare the drop impact studies on replicas of a yellow rose petal, with those on extensively studied red rose petal replicas and the lotus leaf over a wide range of Weber number (We), by varying the height of fall (h) from 10 to 375 mm. Our results reveal that over the replica of a yellow rose petal, the initial impact outcome varies from complete rebound to micro pinning and eventually complete pinning depending on the kinetic energy of the impacting drop, in contrast to that on red rose petal replica on which the droplet always pinned. Based on experimental finding, we present a comprehensive regime phase map of the post impact behavior of the drop on different surfaces as a function of impact height. We also present a simple scaling analysis to understand the combined effect of pattern height and periodicity on the critical h corresponding to wetting regime transition. Additionally, variation of maximum spreading diameter and spreading time with the h for the different surfaces is also discussed. The results highlight that the initial impact dynamics of a water drop over a topographically patterned substrate is a strong function of the topographical parameters and can be very different from the equilibrium wetting state.

Non-wetting Liquid-Infused Slippery Paper.

Liquid-infused slippery surfaces have replaced structural superhydrophobic surfaces in a plethora of emerging applications, hallmarked by their favorable self-healing and liquid-repelling characteristics. Their ease of fabrication on different types of materials and increasing demand in various industrial applications have triggered research interests targeted toward developing an environmental-friendly, flexible, and frugal substrate as the underlying structural and functional backbone. Although many expensive polymers such as polytetrafluoroethylene have so far been used for their fabrication, these are constrained by their compromised flexibility and non-ecofriendliness due to the use of fluorine. Here, we explore the development and deployment of a biodegradable, recyclable, flexible, and an economically viable material in the form of a paper matrix for fabricating liquid-infused slippery interfaces for prolonged usage. We show by controlled experiments that a simple silanization followed by an oil infusion protocol imparts an inherent slipperiness (low contact angle hysteresis and low tilting angle for sliding) to the droplet motion on the paper substrate and provides favorable anti-icing characteristics, albeit keeping the paper microstructures unaltered. This ensures concomitant hydrophobicity, water adhesion, and capillarity for low surface tension fluids, such as mustard oil, with an implicit role played by the paper pore size distribution toward retaining a stable layer of the infused oil. With demonstrated supreme anti-icing characteristics, these results open up new possibilities of realizing high-throughput paper-based substrates for a wide variety of applications ranging from biomedical unit operations to droplet-based digital microfluidics.

High Temperature Durability of Oleoplaned Slippery Copper Surfaces.

Slippery surfaces, inspired by the functionality of trapping interfaces of specialized leaves of pitcher plants, have been widely used in self-cleaning, anti-icing, antifrost, and self-healing surfaces. They can be fabricated on metallic surfaces as well, presenting a more durable and low-maintenance anticorrosive surface on metals. However, the lack of studies on the durability of these slippery surfaces at high temperature prohibits their practical deployment in real industrial applications where thermal effects are critical and high temperature conditions are inevitable. We present here a unique fabrication technique of a copper-based oleoplaned slippery surface that has been tested for high temperature durability under repeated thermal cycles. Their slipperiness at high temperatures has also been tested in the absence of the Leidenfrost effect. Our findings suggest that these new substrates can be used for fabricating low maintenance surfaces for high temperature applications or even where the surface undergoes repeated thermal cycles like heat exchanger pipes, utensils, engine casings, and outdoor metallic structures.

Tunable adhesion and slip on a bio-mimetic sticky soft surface.

Simultaneous tuning of wettability and adhesion of a surface requires intricate procedures for altering the interfacial structures. Here, we present a simple method for preparing a stable slippery surface, with an intrinsic capability of varying its adhesion characteristics. Cross-linked PDMS, an inherent hydrophobic material commonly used for microfluidic applications, is used to replicate the structures on the surface of a rose petal which acts as a high adhesion solid base and is subsequently oleoplaned with silicone oil. Our results demonstrate that the complex hierarchical rose petal structures can arrest dewetting of the silicone oil on the cross linked PDMS base by anchoring the oil film strongly even under flow. Further, by tuning the extent of submergence of the rose petal structures with silicone oil, we could alter the adhesion characteristics of the surface on demand, while retaining its slippery characteristics for a wide range of the pertinent parameters. We have also demonstrated the possible fabrication of gradient adhesion surfaces. This, in turn, may find a wide variety of applications in water harvesting, droplet maneuverability and no-loss transportation in resource-limited settings.

Tailored topography: a novel fabrication technique using an elasticity gradient.

A facile methodology to create a wrinkled surface with a tailored topography is presented herein. The dependency of the elasticity of poly(dimethyl)siloxane (PDMS) on the curing temperature has been exploited to obtain a substrate with an elasticity gradient. The temperature gradient across the length of PDMS is created by a novel set-up consisting of a metal and insulator connected to a heater and the highest usable (no degradation of PDMS) temperature gradient is used. The time-dependent temperature distributions along the substrate are measured and the underlying physics of the dependence of the PDMS elasticity on the curing temperature is addressed. The PDMS substrate with the elasticity gradient is first stretched and subsequently oxidized by oxygen plasma. Upon relaxation, an ordered wrinkled surface with continuously varying wavelength and amplitude along the length of PDMS is obtained. The extent of hydrophobicity recovery of this plasma oxidized PDMS with varying elasticity has been studied. The change in the wavelength and amplitude of the regular patterns on the substrate can be controlled by varying operational parameters like applied pre-strain, plasma power and the heater temperature. It has been found that the spatial distributions of the topography and the hydrophobicity collectively decide the resultant wettability of the substrate. Such surfaces with gradients in the substructure dimensions demonstrate different wetting characteristics that may lead to a wide gamut of applications including droplet movement, cell adhesion and proliferation, diffraction grating etc.

Anisotropic Electrowetting on Wrinkled Surfaces: Enhanced Wetting and Dependency on Initial Wetting State.

Electrowetting on dielectric (EWOD) on unidirectional microstructured surfaces has recently evoked significant interest as they can modulate the effect of electrowetting, and can thus find applications in directional wetting in microfluidic systems. However, the dependency of such EW phenomenon on their initial state of wetting and anisotropy is far from being well understood. The current study addresses the initial wetting states and their implication on the anisotropic electrowetting using a wrinkled EWOD platform. Herein we demonstrate a facile stampless and maskless structure generation technique to fabricate wrinkles of varying topography. Further, we have demonstrated alteration in the interfacial wetting conditions by modulating the wrinkle topography, and its effect on the droplet behavior during electrowetting. The capillary wicking-assisted electrowetting on these wrinkled surfaces is in specific direction dictated by the ordered wrinkles and prompts enhanced spreading of the droplet. We also demonstrate that while the enhancement of unidirectional electrowetting is stronger in conformal wetting state surfaces, composite wetting state surfaces depict a reversal in anisotropy.