1.
Bioorg Med Chem Lett
; 17(15): 4378-81, 2007 Aug 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17574417
RESUMO
Novel anthranilamides were surprisingly found to exert additional activity on B-RAF. Corresponding thiophene, pyrazole, and thiazole core analogs were prepared as VEGFR-2 inhibitors with c-KIT, and B-RAF activity. Compounds in the phenyl, thiophene, and thiazole series are in vivo active.