A shared novelty-seeking basis for creativity and curiosity: Response to the commentators.

In our target article, we proposed that curiosity and creativity are both manifestations of the same novelty-seeking process. We received 29 commentaries from diverse disciplines that add insights to our initial proposal. These commentaries ultimately expanded and supplemented our model. Here we draw attention to five central practical and theoretical issues that were raised by the commentators: (1) The complex construct of novelty and associated concepts; (2) the underlying subsystems and possible mechanisms; (3) the different pathways and subtypes of curiosity and creativity; (4) creativity and curiosity "in the wild"; (5) the possible link(s) between creativity and curiosity.

Context as a barrier: Impaired contextual processing increases the tendency to develop PTSD symptoms across repeated exposure to trauma.

Growing evidence links repeated traumatic exposure with impaired ability to process contextual information. Specifically, like individuals with PTSD, non-PTSD trauma-exposed individuals fail to react according to contextual demands. In the present study, we explored the process that underlies this impairment. First, we tested the ability of first responders to benefit from contextual primes to improve recognition. Second, we assessed its moderating role in the relationship between traumatic exposure and PTSD symptoms. Fifty-three active-duty firefighters and 33 unexposed civilians matched for age, gender, and years of education participated in the study. All participants completed the contextual priming paradigm, the CAPS-5 clinical interview, and the WAIS-IV vocabulary subtest and were assessed for depression and general traumatic exposure. Repeated traumatic exposure was assessed objectively using the fire-and-rescue-service tracking system. As predicted, we found that trauma-exposed individuals failed to use primes to facilitate rapid and accurate recognition of contextually related objects. Not only did contextual information not improve performance, but it achieved the opposite effect, manifested as negative priming. Hence, context appeared to be an obstacle for trauma-exposed individuals and delayed rapid and accurate recognition. Moreover, impaired ability to process contextual information predicted the tendency to develop PTSD symptoms across repeated exposure to trauma.

A shared novelty-seeking basis for creativity and curiosity.

Curiosity and creativity are central pillars of human growth and invention. While they have been studied extensively in isolation, the relationship between them has not yet been established. We propose that curiosity and creativity both emanate from the same mechanism of novelty-seeking. We first present a synthesis showing that curiosity and creativity are affected similarly by a number of key cognitive faculties such as memory, cognitive control, attention, and reward. We then review empirical evidence from neuroscience research, indicating that the same brain regions are involved in both curiosity and creativity, focusing on the interplay between three major brain networks: the default-mode network, the salience network, and the executive control network. After substantiating the link between curiosity and creativity, we propose a novelty-seeking model (NSM) that underlies them both and suggest that the manifestation of the NSM is governed by one's state of mind (SoM).

Price reductions in hearing aids and access to audiologists, Israel.

Problem: Hearing rehabilitation with hearing aids is a complex process which requires professional expertise and the involvement of audiologists or hearing-care specialists. Professional care, however, requires extra resources, making it tempting to rely solely on technology and reduce the role of professional counselling. Approach: To reduce the out-of-pocket share for adults needing hearing rehabilitation, in 2011 the Israeli government tripled the subsidy for adult hearing aids by converting 3 years of subsidies into a triennial, enlarged fund. Regulations for providing hearing rehabilitation and a set of rules for tenders for the supply of hearing aids were issued. Local setting: Auditory diagnosis and rehabilitation are included in the Israeli national health insurance system. Before 2011, the annual government-funded subsidy for hearing aids was negligible; hearing aids were expensive and bought mostly with patients' own resources. Relevant changes: A series of tenders for companies to supply hearing aids, aiming to control public and individual expenses, resulted in a large reduction in prices, which in turn raised the demand for hearing aids and increased public expenditure. As the price of hearing aids fell markedly, hearing rehabilitation is approaching a point of becoming limited to supplying hearing devices, while reducing the importance placed on professional elements of the rehabilitation course. Lessons learnt: Lowering out-of-pocket costs for patients should not be the only consideration in hearing rehabilitation. Our goal should be to control public expenditure but also provide affordable hearing aids with sufficient intervention of hearing-care specialists, to ensure access to advanced technologies and proper professional care.

How associative thinking influences scene perception.

Perception of our external environment is not isolated from the influence of our internal thoughts, and past evidence points to a possible common associative mechanism underlying both the perception of scenes and our internal thought. Here, we investigated the nature of the interaction between an associative mindset and scene perception, hypothesizing a functional advantage to an associative thought pattern in the perception of scenes. Experiments 1 and 2 showed that associative thinking facilitates scene perception, which evolved over the course of the experiments. In contrast to scene perception, Experiment 3 showed that associative thinking hinders the perception of mundane objects, in which associative information is minimized. Nevertheless, object perception was facilitated when associative thinking was reduced. This double dissociation suggests that an associative mind is more receptive of externally perceived associative information, and that a match between the orientation of internal and external processing may be key for perception.

Constricted semantic relations in acute depression.

BACKGROUND: It has been suggested that mood influences the breadth of associated information available for retrieval, with positive mood broadening and negative mood constricting the scope of associations. In this study, we asked whether this mood-associations connection is related to controlled processes which were linked to clinical symptoms in depression. METHODS: We used the semantic priming paradigm, which allows the dissociation of automatic and controlled processes by using short and long intervals between prime and target words. We further examined whether the strength of semantic relations (weak or strong) influence the priming effects in both neurotypical and depressed individuals. RESULTS: Experiment 1, testing neurotypical individuals, showed priming effects for strong semantically-related words regardless of interval length, but priming effects for weak semantically-related words were smaller in short intervals than in long intervals. Experiment 2, testing depressed individuals in long intervals, showed smaller priming effects for weak semantically-related words than shown by neurotypicals, but priming effects for strong semantically-related words which were comparable between the groups. LIMITATIONS: This study cannot determine the source for the differences in priming effects between depressed individuals and neurotypicals, and further studies are needed. CONCLUSIONS: This is the first study to show priming impairments in depressed individuals. We discuss our results in light of leading theories concerning cognitive impairment in depression, as well as the newly emerged field of digital psychiatry.

Increased associative interference under high cognitive load.

Associative processing is central for human cognition, perception and memory. But while associations often facilitate performance, processing irrelevant associations can interfere with performance, for example when learning new information. The aim of this study was to explore whether associative interference is influenced by contextual factors such as resources availability. Experiments 1-3 show that associative interference increases under high cognitive load. This result generalized to both long-term and short-term memory associations, and to both explicitly learned as well as incidentally learned associations in the linguistic and pictorial domains. Experiment 4 further revealed that attention to associative information can delay one's perceptual processing when lacking resources. Taken together, when resources diminish associative interference increases, and additionally, processing novel and ambiguous information is hindered. These findings bare relevance to other domains as well (e.g., social, educational), in which increased load or stress may prompt an undesirable bias towards prior, misleading information.

Oculomotor anticipation reveals a multitude of learning processes underlying the serial reaction time task.

Sequence learning is the cognitive faculty enabling everyday skill acquisition. In the lab, it is typically measured in speed of response to sequential stimuli, whereby faster responses are taken to indicate improved anticipation. However, response speed is an indirect measure of anticipation, that can provide only limited information on underlying processes. As a result, little is known about what is learned during sequence learning, and how that unfolds over time. In this work, eye movements that occurred before targets appeared on screen in an ocular serial reaction time (O-SRT) task provided an online indication of where participants anticipated upcoming targets. When analyzed in the context of the stimuli preceding them, oculomotor anticipations revealed several simultaneous learning processes. These processes influenced each other, as learning the task grammar facilitated acquisition of the target sequence. However, they were dissociable, as the grammar was similarly learned whether a repeating sequence inhabited the task or not. Individual differences were found in how the different learning processes progressed, allowing for similar performance to be produced for different latent reasons. This study provides new insights into the processes subserving sequence learning, and a new method for high-resolution study of it.

Outcomes of sublobar resection vs lobectomy for invasive clinical stage T1N0 non-small-cell lung cancer: A propensity-match analysis.

BACKGROUND: The role of sub lobar resection (SLR; either segmentectomy or wedge resection) vs lobectomy (LBCT) for invasive clinical stage T1N0 non-small-cell-lung-cancer (NSCLC) has not been fully established yet. AIM: We aimed to characterize the preoperative parameters leading to selecting SLR and compare the overall survival (OS) and disease-free survival (DFS) of these two surgical approaches. METHODS: Clinical data on 162 patients (LBCT-107; SLR-55) were prospectively entered in our departmental database. Preoperative parameters associated with the performance of SLR were identified using univariate and multivariate cox regression analysis. The Kaplan-Meier method was used to compute OS and DFS. Comparison between LBCT and SLR groups and 32 propensity-matched groups was performed using Log-rank test. RESULTS: Median follow-up time for the LBCT and SLR groups was 4.76 (Inter-quartile range [IQR] 2.96 to 8.23) and 3.38 (IQR 2.9 to 6.19) years respectively. OS and DFS rates were similar between the two groups in the entire cohort (OS-LBCT vs SLR P = .853, DSF-LBCT vs SLR P = .653) and after propensity matching (OS-LBCT vs SLR P = .563 DSF-LBCT vs SLR P = .632). Specifically, Two- and five-year OS rates for LBCT and SLR were 90.6.% vs 92.7%, 71.8% vs 75.9% respectively. Independent predictors of selecting for SLR included older age (P < .001), reduced FEV1% (P = .026), smaller tumor size (P = .025), smaller invasive component (P = .021) and higher American Society of Anesthesiology scores (P = .014). CONCLUSIONS: In 162 consecutive and 32 matched cases, SLR and lobar resection had similar overall and disease-free survival rates. SLR may be considered as a reasonable oncological procedure in carefully selected T1N0 NSCLC patients that present with multiple comorbidities and relatively small tumors.

Perceptual decisions are biased toward relevant prior choices.

Perceptual decisions are biased by recent perceptual history-a phenomenon termed 'serial dependence.' Here, we investigated what aspects of perceptual decisions lead to serial dependence, and disambiguated the influences of low-level sensory information, prior choices and motor actions. Participants discriminated whether a brief visual stimulus lay to left/right of the screen center. Following a series of biased 'prior' location discriminations, subsequent 'test' location discriminations were biased toward the prior choices, even when these were reported via different motor actions (using different keys), and when the prior and test stimuli differed in color. By contrast, prior discriminations about an irrelevant stimulus feature (color) did not substantially influence subsequent location discriminations, even though these were reported via the same motor actions. Additionally, when color (not location) was discriminated, a bias in prior stimulus locations no longer influenced subsequent location discriminations. Although low-level stimuli and motor actions did not trigger serial-dependence on their own, similarity of these features across discriminations boosted the effect. These findings suggest that relevance across perceptual decisions is a key factor for serial dependence. Accordingly, serial dependence likely reflects a high-level mechanism by which the brain predicts and interprets new incoming sensory information in accordance with relevant prior choices.

Overarching States of Mind.

We all have our varying mental emphases, inclinations, and biases. These individual dispositions are dynamic in that they can change over time and context. We propose that these changing states of mind (SoMs) are holistic in that they exert all-encompassing and coordinated effects simultaneously on our perception, attention, thought, affect, and behavior. Given the breadth of their reach, understanding how SoMs operate is essential. We provide evidence and a framework for the concept of SoM, and we propose a unifying principle for the underlying cortical mechanism whereby SoM is determined by the balance between top-down (TD) and bottom-up (BU) processing. This novel global account gives rise to unique hypotheses and opens new horizons for understanding the human mind.

Inferior parietal lobule and early visual areas support elicitation of individualized meanings during narrative listening.

INTRODUCTION: When listening to a narrative, the verbal expressions translate into meanings and flow of mental imagery. However, the same narrative can be heard quite differently based on differences in listeners' previous experiences and knowledge. We capitalized on such differences to disclose brain regions that support transformation of narrative into individualized propositional meanings and associated mental imagery by analyzing brain activity associated with behaviorally assessed individual meanings elicited by a narrative. METHODS: Sixteen right-handed female subjects were instructed to list words that best described what had come to their minds while listening to an eight-minute narrative during functional magnetic resonance imaging (fMRI). The fMRI data were analyzed by calculating voxel-wise intersubject correlation (ISC) values. We used latent semantic analysis (LSA) enhanced with Wordnet knowledge to measure semantic similarity of the produced words between subjects. Finally, we predicted the ISC with the semantic similarity using representational similarity analysis. RESULTS: We found that semantic similarity in these word listings between subjects, estimated using LSA combined with WordNet knowledge, predicting similarities in brain hemodynamic activity. Subject pairs whose individual semantics were similar also exhibited similar brain activity in the bilateral supramarginal and angular gyrus of the inferior parietal lobe, and in the occipital pole. CONCLUSIONS: Our results demonstrate, using a novel method to measure interindividual differences in semantics, brain mechanisms giving rise to semantics and associated imagery during narrative listening. During listening to a captivating narrative, the inferior parietal lobe and early visual cortical areas seem, thus, to support elicitation of individual meanings and flow of mental imagery.

Natural genetic variation for expression of a SWEET transporter among wild species of Solanum lycopersicum (tomato) determines the hexose composition of ripening tomato fruit.

The sugar content of Solanum lycopersicum (tomato) fruit is a primary determinant of taste and quality. Cultivated tomato fruit are characterized by near-equimolar levels of the hexoses glucose and fructose, derived from the hydrolysis of translocated sucrose. As fructose is perceived as approximately twice as sweet as glucose, increasing its concentration at the expense of glucose can improve tomato fruit taste. Introgressions of the FgrH allele from the wild species Solanum habrochaites (LA1777) into cultivated tomato increased the fructose-to-glucose ratio of the ripe fruit by reducing glucose levels and concomitantly increasing fructose levels. In order to identify the function of the Fgr gene, we combined a fine-mapping strategy with RNAseq differential expression analysis of near-isogenic tomato lines. The results indicated that a SWEET protein was strongly upregulated in the lines with a high fructose-to-glucose ratio. Overexpressing the SWEET protein in transgenic tomato plants dramatically reduced the glucose levels and increased the fructose : glucose ratio in the developing fruit, thereby proving the function of the protein. The SWEET protein was localized to the plasma membrane and expression of the SlFgr gene in a yeast line lacking native hexose transporters complemented growth with glucose, but not with fructose. These results indicate that the SlFgr gene encodes a plasma membrane-localized glucose efflux transporter of the SWEET family, the overexpression of which reduces glucose levels and may allow for increased fructose levels. This article identifies the function of the tomato Fgr gene as a SWEET transporter, the upregulation of which leads to a modified sugar accumulation pattern in the fleshy fruit. The results point to the potential of the inedible wild species to improve fruit sugar accumulation via sugar transport mechanisms.

Prediction is Production: The missing link between language production and comprehension.

Language comprehension often involves the generation of predictions. It has been hypothesized that such prediction-for-comprehension entails actual language production. Recent studies provided evidence that the production system is recruited during language comprehension, but the link between production and prediction during comprehension remains hypothetical. Here, we tested this hypothesis by comparing prediction during sentence comprehension (primary task) in participants having the production system either available or not (non-verbal versus verbal secondary task). In the primary task, sentences containing an expected or unexpected target noun-phrase were presented during electroencephalography recording. Prediction, measured as the magnitude of the N400 effect elicited by the article (expected versus unexpected), was hindered only when the production system was taxed during sentence context reading. The present study provides the first direct evidence that the availability of the speech production system is necessary for generating lexical prediction during sentence comprehension. Furthermore, these important results provide an explanation for the recruitment of language production during comprehension.

Non-functioning pancreatic neuroendocrine tumors: Surgery or observation?

Incidentally detected, sporadic, nonfunctional pancreatic neuroendocrine tumors are increasingly diagnosed on imaging studies performed for unrelated purposes. Although their resection is usually recommended, controversy still exists regarding their optimal management, due to their highly variable and difficult to predict biologic behavior. Recently, several studies and guidelines advocated an expectant management approach in small size, low grade, incidentally diagnosed nonfunctional pancreatic neuroendocrine tumors. The aim of this study is to review and summarize the available literature addressing nonfunctional pancreatic neuroendocrine tumors, with an emphasis on surgical management controversies.

Internal valence modulates the speed of object recognition.

Brain regions that process affect are strongly connected with visual regions, but the functional consequences of this structural organization have been relatively unexplored. How does the momentary affect of an observer influence perception? We induced either pleasant or unpleasant affect in participants and then recorded their neural activity using magnetoencephalography while they completed an object recognition task. We hypothesized, and found, that affect influenced the speed of object recognition by modulating the speed and amplitude of evoked responses in occipitotemporal cortex and regions important for representing affect. Furthermore, affect modulated functional interactions between affective and perceptual regions early during perceptual processing. These findings indicate that affect can serve as an important contextual influence on object recognition processes.

Associated Information Increases Subjective Perception of Duration.

Our sense of time is prone to various biases. For instance, one factor that can dilate an event's perceived duration is the violation of predictions; when a series of repeated stimuli is interrupted by an unpredictable oddball. On the other hand, when the probability of a repetition itself is manipulated, predictable conditions can also increase estimated duration. This suggests that manipulations of expectations have different or even opposing effects on time perception. In previous studies, expectations were generated because stimuli were repeated or because the likelihood of a sequence or a repetition was varied. In the natural environment, however, expectations are often built via associative processes, for example, the context of a kitchen promotes the expectation of plates, appliances, and other associated objects. Here, we manipulated such association-based expectations by using oddballs that were either contextually associated or nonassociated with the standard items. We find that duration was more strongly overestimated for contextually associated oddballs. We reason that top-down attention is biased toward associated information, and thereby dilates subjective duration for associated oddballs. Based on this finding, we propose an interplay between top-down attention and predictive processing in the perception of time.

The default network and the combination of cognitive processes that mediate self-generated thought.

Self-generated cognitions, such as recalling personal memories or empathizing with others, are ubiquitous and essential for our lives. Such internal mental processing is ascribed to the Default Mode Network, a large network of the human brain, though the underlying neural and cognitive mechanisms remain poorly understood. Here, we tested the hypothesis that our mental experience is mediated by a combination of activities of multiple cognitive processes. Our study included four functional MRI experiments with the same participants and a wide range of cognitive tasks, as well as an analytical approach that afforded the identification of cognitive processes during self-generated cognition. We showed that several cognitive processes functioned simultaneously during self-generated mental activity. The processes had specific and localized neural representations, suggesting that they support different aspects of internal processing. Overall, we demonstrate that internally directed experience may be achieved by pooling over multiple cognitive processes.