RESUMO
AIM: Metabolic changes during exercise may affect the accuracy of glucose sensors impacting on Type 1 diabetes (T1D) management. The present study aimed at assessing the performance of the Flash Glucose Monitoring system (isCGM) during exercise and in free-living condition in youth with T1D. METHODS: Seventeen youth (53% male), aged 13.7⯱â¯3.8â¯years, with T1D for 5.4⯱â¯3.8â¯years, HbA1c 7.4⯱â¯1.0% (57⯱â¯11â¯mmol/mol), were enrolled. Paired isCGM, plasma (PG) and capillary (CG) glucose values (total of 136) were collected during an interval exercise (45â¯min at 55% VO2max load with 20â¯s sprints at 80% VO2max every 10â¯min). Paired isCGM and CG (total of 832) were collected during free-living condition. RESULTS: During exercise, isCGM absolute relative difference (ARDs) means/medians were 12.5/9.4% versus PG and 15.4/10.8% versus CG. During rest, ARDs means/medians were 16.6/12.0%. The Consensus Error Grid analysis showed 98.4% of readings during exercise and 97.24% during rest in zones Aâ¯+â¯B. Percentage of readings meeting the ISO criteria for CG levels <5.55â¯mmol/L was 62.5% during exercise, 53.4% during rest; for CG levels ≥5.55â¯mmol/L was 64.0% during exercise, 60.4% during rest. CONCLUSIONS: isCGM demonstrated similar clinical safety and performance during exercise and in everyday life; further studies are needed to confirm its accuracy during exercise.