RESUMO
BACKGROUND: There are no guidelines to screen haemato-oncologic children when a tuberculosis (TB) outbreak is suspected. METHODS: After exposition to an adult with active TB, children exposed from a haemato-oncology unit were screened according to immunosuppression status and time of exposure. Until an evaluation after 8-12 weeks from last exposure, isoniazid was indicated to those with negative initial work-up. RESULTS: After 210 interventions, we detected a case of pulmonary TB, and another with latent TB infection. Pulmonary findings and treatment approach were challenging in some patients. CONCLUSIONS: The TB screening of oncologic children required a multidisciplinary approach, and clinicians managed challenging situations.
Assuntos
Tuberculose Latente , Tuberculose , Adulto , Antituberculosos/uso terapêutico , Criança , Humanos , Isoniazida , Tuberculose Latente/diagnóstico , Prevalência , Tuberculose/diagnóstico , Tuberculose/epidemiologia , Tuberculose/prevenção & controleRESUMO
BACKGROUND: There are no guidelines to screen haemato-oncologic children when a tuberculosis (TB) outbreak is suspected. METHODS: After exposition to an adult with active TB, children exposed from a haemato-oncology unit were screened according to immunosuppression status and time of exposure. Until an evaluation after 8-12 weeks from last exposure, isoniazid was indicated to those with negative initial work-up. RESULTS: After 210 interventions, we detected a case of pulmonary TB, and another with latent TB infection. Pulmonary findings and treatment approach were challenging in some patients. CONCLUSIONS: The TB screening of oncologic children required a multidisciplinary approach, and clinicians managed challenging situations.
Assuntos
Neoplasias Hepáticas/complicações , Neoplasias de Tecido Conjuntivo/patologia , Neoplasias Embrionárias de Células Germinativas/complicações , Sarcoma/complicações , Adolescente , Terapia Combinada , Feminino , Humanos , Neoplasias Hepáticas/terapia , Neoplasias de Tecido Conjuntivo/tratamento farmacológico , Neoplasias de Tecido Conjuntivo/etiologia , Neoplasias Embrionárias de Células Germinativas/terapia , Osteomalacia , Síndromes Paraneoplásicas , Prognóstico , Sarcoma/terapiaRESUMO
La histiocitosis de células de Langerhans es una enfermedad infrecuente en el lactante y su presentación como una adenitis cervical aislada sin otra sintomatología es excepcional en estos pacientes. Se describe el caso de una lactante de 3 meses de edad que presentaba una tumoración cervical en el ángulo mandibular derecho, con mala respuesta al tratamiento antibiótico. Se realizó una punción-aspiración con aguja fina, que confirmó el diagnóstico de histiocitosis de células de Langerhans. El estudio de extensión no mostró afectación sistémica. Debe considerarse la histiocitosis de células de Langerhans en el diagnóstico diferencial de una masa cervical subaguda de evolución tórpida en los lactantes de corta edad y se debe plantear la realización de una punción-aspiración con aguja fina de manera precoz para establecer el diagnóstico.
Langerhans cell histiocytosis in infants is a rare condition, and presentation as an isolated cervical adenitis is exceptional at this age. We describe the case of a 3-month-old female infant presenting with a neck mass in the right mandibular angle with poor response to antibiotic treatment. Fine needle aspiration was performed and confirmed the diagnosis of Langerhans cell histiocytosis with complementary tests showing no features of systemic involvement. Langerhans cell histiocytosis should be considered in the differential diagnosis of subacute neck masses with poor outcome in infants and physicians should consider performing a fine needle aspiration to establish the diagnosis.
Assuntos
Humanos , Feminino , Lactente , Histiocitose de Células de Langerhans/diagnóstico , Histiocitose de Células de Langerhans/complicações , Linfadenite/etiologia , PescoçoRESUMO
Langerhans cell histiocytosis in infants is a rare condition, and presentation as an isolated cervical adenitis is exceptional at this age. We describe the case of a 3-month-old female infant presenting with a neck mass in the right mandibular angle with poor response to antibiotic treatment. Fine needle aspiration was performed and confirmed the diagnosis of Langerhans cell histiocytosis with complementary tests showing no features of systemic involvement. Langerhans cell histiocytosis should be considered in the differential diagnosis of subacute neck masses with poor outcome in infants and physicians should consider performing a fine needle aspiration to establish the diagnosis.
La histiocitosis de células de Langerhans es una enfermedad infrecuente en el lactante y su presentación como una adenitis cervical aislada sin otra sintomatología es excepcional en estos pacientes. Se describe el caso de una lactante de 3 meses de edad que presentaba una tumoración cervical en el ángulo mandibular derecho, con mala respuesta al tratamiento antibiótico. Se realizó una punción-aspiración con aguja fina, que confirmó el diagnóstico de histiocitosis de células de Langerhans. El estudio de extensión no mostró afectación sistémica. Debe considerarse la histiocitosis de células de Langerhans en el diagnóstico diferencial de una masa cervical subaguda de evolución tórpida en los lactantes de corta edad y se debe plantear la realización de una punción-aspiración con aguja fina de manera precoz para establecer el diagnóstico.
Assuntos
Histiocitose de Células de Langerhans/diagnóstico , Feminino , Histiocitose de Células de Langerhans/complicações , Humanos , Lactente , Linfadenite/etiologia , PescoçoRESUMO
Most studies focusing on respiratory infections in immunocompromised children have been addressed to bacterial etiology. However, respiratory virus infections in this population can also lead to severe disease. The objective of this study is to evaluate the clinical significance of respiratory virus infections in children with cancer or human immunodeficiency virus (HIV) infection. Retrospective study conducted in a teaching hospital in Madrid. Medical records from children Assuntos
Infecções por HIV/complicações
, Hospedeiro Imunocomprometido
, Neoplasias/complicações
, Infecções Respiratórias/epidemiologia
, Infecções Respiratórias/imunologia
, Infecções Respiratórias/virologia
, Adolescente
, Antibacterianos/uso terapêutico
, Antivirais/uso terapêutico
, Criança
, Infecção Hospitalar/epidemiologia
, Infecção Hospitalar/imunologia
, Infecção Hospitalar/virologia
, Feminino
, Humanos
, Masculino
, Estudos Retrospectivos
, Viroses/tratamento farmacológico
, Viroses/epidemiologia
, Viroses/imunologia