5-MeO-DMT for post-traumatic stress disorder: a real-world longitudinal case study.

Psychedelic therapy is, arguably, the next frontier in psychiatry. It offers a radical alternative to longstanding, mainstays of treatment, while exciting a paradigm shift in translational science and drug discovery. There is particular interest in 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT)-a serotonergic psychedelic-as a novel, fast-acting therapeutic. Yet, few studies have directly examined 5-MeO-DMT for trauma- or stress-related psychopathology, including post-traumatic stress disorder (PTSD). Herein, we present the first longitudinal case study on 5-MeO-DMT for chronic refractory PTSD, in a 23-year-old female. A single dose of vaporized bufotoxin of the Sonoran Desert Toad (Incilius alvarius), containing an estimated 10-15 mg of 5-MeO-DMT, led to clinically significant improvements in PTSD, with next-day effects. This was accompanied by marked reductions in hopelessness and related suicide risk. Improvements, across all constructs, were sustained at 1-, 3-, 6-, and 12-months follow-up, as monitored by a supporting clinician. The subject further endorsed a complete mystical experience, hypothesized to underly 5-MeO-DMT's therapeutic activity. No drug-related, serious adverse events occurred. Together, results showed that 5-MeO-DMT was generally tolerable, safe to administer, and effective for PTSD; however, this was not without risk. The subject reported acute nausea, overwhelming subjective effects, and late onset of night terrors. Further research is warranted to replicate and extend these findings, which are inherently limited, non-generalizable, and rely on methods not clinically accepted.

Insight Problem Solving Ability Predicts Reduced Susceptibility to Fake News, Bullshit, and Overclaiming.

The information humans are exposed to has grown exponentially. This has placed increased demands upon our information selection strategies resulting in reduced fact-checking and critical-thinking time. Prior research shows that problem solving (traditionally measured using the Cognitive Reflection Test-CRT) negatively correlates with believing in false information. We argue that this result is specifically related to insight problem solving. Solutions via insight are the result of parallel processing, characterized by filtering external noise, and, unlike cognitively controlled thinking, it does not suffer from the cognitive overload associated with processing multiple sources of information. We administered the Compound Remote Associate Test (problems used to investigate insight problem solving) as well as the CRT, 20 fake and real news headlines, the bullshit, and overclaiming scales to a sample of 61 participants. Results show that insight problem solving predicts better identification of fake news and bullshit (over and above traditional measures i.e., the CRT), and is associated with reduced overclaiming. These results have implications for understanding individual differences in susceptibility to believing false information.

Humans versus AI: whether and why we prefer human-created compared to AI-created artwork.

With the recent proliferation of advanced artificial intelligence (AI) models capable of mimicking human artworks, AI creations might soon replace products of human creativity, although skeptics argue that this outcome is unlikely. One possible reason this may be unlikely is that, independent of the physical properties of art, we place great value on the imbuement of the human experience in art. An interesting question, then, is whether and why people might prefer human-compared to AI-created artworks. To explore these questions, we manipulated the purported creator of pieces of art by randomly assigning a "Human-created" or "AI-created" label to paintings actually created by AI, and then assessed participants' judgements of the artworks across four rating criteria (Liking, Beauty, Profundity, and Worth). Study 1 found increased positive judgements for human- compared to AI-labelled art across all criteria. Study 2 aimed to replicate and extend Study 1 with additional ratings (Emotion, Story, Meaningful, Effort, and Time to create) intended to elucidate why people more-positively appraise Human-labelled artworks. The main findings from Study 1 were replicated, with narrativity (Story) and perceived effort behind artworks (Effort) moderating the label effects ("Human-created" vs. "AI-created"), but only for the sensory-level judgements (Liking, Beauty). Positive personal attitudes toward AI moderated label effects for more-communicative judgements (Profundity, Worth). These studies demonstrate that people tend to be negatively biased against AI-created artworks relative to purportedly human-created artwork, and suggest that knowledge of human engagement in the artistic process contributes positively to appraisals of art.

Creativity, Boredom Proneness and Well-Being in the Pandemic.

Throughout the course of the pandemic, it has become clear that the strictures of social isolation and various levels of lockdown constraints have impacted people's well-being. Here, our aim was to explore relations between trait dispositions associated with boredom proneness, self-regulation and well-being using data collected early in the pandemic. Specifically, we explored whether the tendency to engage in everyday creative pursuits (e.g., making your own greeting cards) would act as a prophylactic against poor well-being. Results showed that well-being was higher for those individuals who increased engagement with creative pursuits during the early stages of the pandemic. That is, people who engaged more in everyday creative activities also reported higher levels of self-esteem, optimism, and positive affect. In contrast, those who pursued fewer creative outlets had higher levels of depression and anxiety, were higher in boredom proneness, and reported experiencing more negative affect. As we emerge from the pandemic, these data provide a clue as to how people might plan to cope adaptively with the restrictive circumstances this extreme world event engendered. More generally, these data provide support for the notion that everyday creativity (and not necessarily creative expertise) has positive associations for well-being.

Wandering minds and wavering goals: Examining the relation between mind wandering and grit in everyday life and the classroom.

Here we examined the relation between mind wandering and the personality trait of 'grit.' Our hypothesis was that because mind wandering leads to a disruption of momentary goal completion, the tendency to mind wander might be inversely related to the completion of long-term goals that require sustained interest and effort (i.e., grittiness). In Study 1 we used online questionnaires and found that in everyday life, the propensity to mind wander was negatively correlated with individuals' self-reported grittiness. Interestingly, the relation between mind wandering and grit was strongest for unintentional bouts of mind wandering (as compared with intentional mind wandering). We extended these findings in Study 2 by (a) using a more heterogeneous sample of participants, (b) including a measure of conscientiousness, and (c) including another measure of general perseverance. In addition to replicating our findings from Study 1, in Study 2 we found that the grit measure uniquely predicted spontaneous mind wandering over and above a measure of conscientiousness and an alternative measure of general perseverance. Lastly, in Study 3 we extend the relation between mind wandering and grit to the classroom, finding that mind wandering during university lectures was also related to self-reported grittiness. Taken together, we suggest that the propensity to experience brief lapses of attention is associated with the propensity to stick-with and complete long-term goals. We also provide evidence that when predicting mind wandering and inattention, measures of grit are not redundant with existing measure of conscientiousness and general perseverance. (PsycINFO Database Record

Cognitive style and religiosity: the role of conflict detection.

Recent research has indicated a negative relation between the propensity for analytic reasoning and religious beliefs and practices. Here, we propose conflict detection as a mechanism underlying this relation, on the basis of the hypothesis that more-analytic people are less religious, in part, because they are more sensitive to conflicts between immaterial religious beliefs and beliefs about the material world. To examine cognitive conflict sensitivity, we presented problems containing stereotypes that conflicted with base-rate probabilities in a task with no religious content. In three studies, we found evidence that religiosity is negatively related to conflict detection during reasoning. Independent measures of analytic cognitive style also positively predicted conflict detection. The present findings provide evidence for a mechanism potentially contributing to the negative association between analytic thinking and religiosity, and more generally, they illustrate the insights to be gained from integrating individual-difference factors and contextual factors to investigate analytic reasoning.