RESUMO
INTRODUCTION: It is widely accepted that the risk of malignancies is significantly increased among patients with end-stage kidney disease (ESKD) and after kidney transplantation compared with the general population. Only a few data are available on kidney transplantation waiting list patients. The aim of this study was to investigate solid organ cancer incidence among subjects on the waiting list at a single center. MATERIALS AND METHODS: We retrospectively reviewed the records of all patients enrolled on our kidney transplantation waiting list between August 1, 2008 and July 31, 2010, seeking to evaluate the causes of withdrawal from the list, incidence of cancer, type of neoplasm, and its correlation with clinical features. We estimated the ratio of observed to expected numbers of cancers, the standardized incidence ratio (SIR). RESULTS: Among 1184 patients, we excluded 569 patients from the waiting list including 26 (4.56%) who displayed malignancies. The overall incidence of cancer was 0.11 events/person-months and the overall prevalence of cancer was 2.2%. In 97% of patients, the malignant disease was confined to the primitive organ of origin without secondary dissemination. We observed a prevalence of cancers related to ESKD (17; 65.38%). The SIR for all cancer types in our population compared with the general population was 2.22. The SIR for native kidney and thyroid cancers among our population compared with the general population was >10. CONCLUSION: The incidence of cancer was significantly increased among kidney transplantation waiting list patients compared with the general population. Our study highlighted the importance of a careful, targeted neoplastic screening. It could be particularly important for ESKD-related malignancies like native kidney tumors or thyroid cancers.
Assuntos
Falência Renal Crônica/epidemiologia , Transplante de Rim/estatística & dados numéricos , Neoplasias/epidemiologia , Listas de Espera , Adolescente , Adulto , Idoso , Distribuição de Qui-Quadrado , Feminino , Humanos , Incidência , Itália/epidemiologia , Falência Renal Crônica/cirurgia , Masculino , Pessoa de Meia-Idade , Neoplasias/diagnóstico , Neoplasias/terapia , Prevalência , Prognóstico , Estudos Retrospectivos , Fatores de Tempo , Adulto JovemAssuntos
Cefazolina/administração & dosagem , Dicloxacilina/administração & dosagem , Infecções Respiratórias/tratamento farmacológico , Bronquite/tratamento farmacológico , Broncopneumonia/tratamento farmacológico , Criança , Pré-Escolar , Combinação de Medicamentos/administração & dosagem , Feminino , Humanos , Lactente , Masculino , Faringite/tratamento farmacológico , Pleurisia/tratamento farmacológico , Tonsilite/tratamento farmacológicoRESUMO
Five females with duplication of the short arm of one chromosome 9 are reported, one tetrasomic and four trisomic for 9p. The tetrasomy is due to an isochromosome 9p while the trisomies are due in one case to an intrachromosomal duplication present in lymphocytes but not in fibroblasts, two are secondary to translocations with chromosomes 22 and 13 respectively, and one is a mosaic with a cell line with an additional deleted chromosome 9 present in lymphocytes and fibroblasts. This analysis indicates that duplications 9p may result in impairment of ovarian function. The phenotypic differences between trisomy and tetrasomy 9p are discussed.
