Assuntos
Anestésicos Intravenosos/administração & dosagem , Doenças do Gato/diagnóstico , Endoscopia Gastrointestinal/veterinária , Traqueia/lesões , Anestesia Geral/efeitos adversos , Anestesia Geral/métodos , Anestesia Geral/veterinária , Animais , Doenças do Gato/cirurgia , Gatos , Dispneia/etiologia , Dispneia/cirurgia , Dispneia/veterinária , Endoscopia Gastrointestinal/efeitos adversos , Fentanila/administração & dosagem , Intubação Intratraqueal/instrumentação , Intubação Intratraqueal/métodos , Intubação Intratraqueal/veterinária , Masculino , Propofol/administração & dosagem , Ruptura/veterinária , Enfisema Subcutâneo/etiologia , Enfisema Subcutâneo/cirurgia , Enfisema Subcutâneo/veterinária , Traqueia/cirurgia , Resultado do TratamentoRESUMO
We report the development of an interactive approach to single-word language production studies in fMRI. The approach, adaptive pacing, involves real-time adjustment of stimulus presentation times based on individual subject performance timing and content. At the same time, it maintains a stochastic distribution of interstimulus intervals to avoid confounding task covariates with speech-related signal variance. Adaptive pacing of overt speech production is an example of a new class of paradigms that require an observational approach to data acquisition and benefit from a "time-aware" acquisition and processing environment. The advantages of adaptive pacing in fMRI of impaired subjects are expected to be the acquisition of more informative data per unit time, less contamination of data by correlates of non-language processes such as emotion, and facilitation of experiments that combine normal and impaired subjects.