Multimodality therapy for unresectable squamous cell carcinoma of the head and neck.

Eighteen patients with unresectable Stage III or IV squamous cell carcinoma of the head and neck were treated with induction therapy consisting of sequential methotrexate and 5-fluorouracil. This was followed by full course radiation therapy and radical neck dissection for those with residual neck disease. Those with local control were then treated with vinblastine, bleomycin, and cisplatin (VBP). Although 79% of patients achieved a partial or complete response to chemotherapy, only 50% of patients achieved local control. Marked mucositis limited the dose and schedule of radiation therapy. The methotrexate and 5-fluorouracil combination appears to be too toxic for multimodality therapy of advanced head and neck cancer.

[A case of congenital double pyloric canal (author's transl)]. / Uber eine Duplikatur des Pyloruskanals als kongenitale Anomalie (Pylorusband).

In the case of 47-year-old patient who had been suffering for several months from a duodenal ulcer disease, a so called double pylorus was traced by applying fiberoptic gastroscopy. At the same time proof was found for the ulcera duodeni. Owing to the fiberoptic result of two regularly pyloric canals it was already doubted, that this was only a question of a secondary pyloro duodenal fistula caused by peptic ulcer. A particular and differentiating pathological anatomical examination of the surgical specimen showed as a result, that the patient was suffering from a congenital duplication of the pyloric canal by a pyloric ligament. The duodenal ulcers, proofed by x-ray examination and gastroscopy, were recognised as a secondary disease of a locus minoris resistentiae.