[Cardiotoxicity of n-methyl-glucamine antimoniate (Glucantime). A case report]. / Toxicité cardiaque de l'antimoniate de méglumine (Glucantime). A propos d'une observation.

The pentavalent antimonial meglumine (Glucantime) is the drug of choice in treatment of cutaneous leishmaniasis in Tunisia. It may create severe adverse effects. A ten year-old girl was treated by Glucantime for cutaneous leishmaniasis. On the eighth day of treatment, she developed palpitations and precordialgia. The ECG showed T wave inversion prolongation of corrected QT interval. Drug therapy was stopped. Within a few days, she recovered and her elctrocardiographic changes came back to normal. The cardio toxicity of Glucantime may be severe. Electrocardiographic changes are the primary signs. Long term ECG follow-up is necessary.

[Fetal macrosomia and the study of risk factors in maternal diabetes]. / Macrosomie foetale et étude des facteurs de risque de diabète maternel.

The authors report the results of a study performed in 142 women who gave birth to overgrown neonates. Among them, the incidence of diabetes was high: 7.75%. Older maternal age, maternal obesity and the former birth of large infants were also found to be risk factors for fetal overgrowth.