Coronary heart disease classification using deep learning approach with feature selection for improved accuracy.

BACKGROUND: Coronary heart disease (CHD) is one of the deadliest diseases and a risk prediction model for cardiovascular conditions is needed. Due to the huge number of features that lead to heart problems, it is often difficult for an expert to evaluate these huge features into account. So, there is a need of appropriate feature selection for the given CHD dataset. For early CHD detection, deep learning modes (DL) show promising results in the existing studies. OBJECTIVE: This study aimed to develop a deep convolution neural network (CNN) model for classification with a selected number of efficient features using the LASSO (least absolute shrinkage and selection operator) technique. Also, aims to compare the model with similar studies and analyze the performance of the proposed model using accuracy measures. METHODS: The CHD dataset of NHANES (National Health and Nutritional Examination Survey) was examined with 49 features using LASSO technique. This research work is an attempt to apply an improved CNN model for the classification of the CHD dataset with huge features CNN model with feature extractor consists of a fully connected layer with two convolution 1D layers, and classifier part consists of two fully connected layers with SoftMax function was trained on this dataset. Metrics like accuracy recall, specificity, and ROC were used for the evaluation of the proposed model. RESULTS: The feature selection was performed by applying the LASSO model. The proposed CNN model achieved 99.36% accuracy, while previous studies model achieved over 80 to 92% accuracy. CONCLUSION: The application of the proposed CNN with the LASSO model for the classification of CHD can speed up the diagnosis of CHD and appears to be effective in predicting cardiovascular disease based on risk features.

COVID-19 pandemic, predictions and control in Saudi Arabia using SIR-F and age-structured SEIR model.

COVID-19 has affected every individual physically or physiologically, leading to substantial impacts on how they perceive and respond to the pandemic's danger. Due to the lack of vaccines or effective medicines to cure the infection, an urgent control measure is required to prevent the continued spread of COVID-19. This can be achieved using advanced computing, such as artificial intelligence (AI), machine learning (ML), deep learning (DL), cloud computing, and edge computing. To control the exponential spread of the novel virus, it is crucial for countries to contain and mitigate interventions. To prevent exponential growth, several control measures have been applied in the Kingdom of Saudi Arabia to mitigate the COVID-19 epidemic. As the pandemic has been spreading globally for more than a year, an ample amount of data is available for researchers to predict and forecast the effect of the pandemic in the near future. This article interprets the effects of COVID-19 using the Susceptible-Infected-Recovered (SIR-F) while F-stands for 'Fatal with confirmation,' age-structured SEIR (Susceptible Exposed Infectious Removed) and machine learning for smart health care and the well-being of citizens of Saudi Arabia. Additionally, it examines the different control measure scenarios produced by the modified SEIR model. The evolution of the simulation results shows that the interventions are vital to flatten the virus spread curve, which can delay the peak and decrease the fatality rate.

Structural, functional, resistome and pathogenicity profiling of the Cooum river.

The microbial community's structure and functions determine the health, quality, and anthropogenic conditions of the river ecosystems. The presence of Bacteria such as Arcobacter spp, Escherichia spp, and Campylobacters spp, have been shown to reflect the poor water quality of rivers. Apprehension of the microbial community in polluted water bodies is significant because it affects human health and the environment. Culture-independent metagenomic and metatranscriptomic approaches employed in the current study of the Cooum river unraveled the taxonomic classification of diverse microbes, including archaea, bacteria, viruses, and phages. The presence of abundant Macellibacteroides fermentans, Arcobacter bivolvorium, Arcobacter butzleri, Methanothrix soenhngeii, and Bacteroides graminisolvens were noted. Viruses and phages like Caudovirales, Human mastadenovirus C, Siphoviridae, Escherichia phage, Erwinia phage, Synechoccus phage, and Vibrio phage were relatively predominant. Various metabolic pathways like methane, sulfur, and nitrogen metabolism adopted by the microbiome confer dangerous gases. Mechanisms such as secretory systems, signal transduction, Chemotaxis, quorum sensing, transportation of chemicals and ions were significantly enriched. The microbes expressed antimicrobial resistance mechanisms as identified from the genes encoding beta-lactamase enzymes and aminoglycoside phosphotransferase enzymes. Metal resistance mechanisms against copper, tellurium, chromium, and cadmium were plentiful. Presence of human pathogens interactions with Yersinia pestis, Campylobacter jejuni, Escherichia coli, Helicobacter pylori, and Francisella tularensis subsp. tularensis suggested the possibilities of transmission of pathogenesis to humans. The current study is the first to apprehend the detailed microbiome composition of one of the highly polluted rivers in South India. The study elaborated the microbiome's structure, functions, and metabolic potential at a specific site of the polluted river.