Longitudinal magnetic resonance evaluation of the schizophrenia model of neonatal lesion in the ventral hippocampus.

OBJECTIVE: To evaluate the progression by means of nuclear magnetic resonance of the lesion in the schizophrenia model of lesion of the ventral hippocampal nucleus (LVNH). METHOD: Magnetic resonance imaging (MRI) were performed in male Wistar rats, from 8 days postnatal to 139 days, in animals with LNHV and without lesion (sham). The MRI were carried out on a Variant 7 T equipment. The data were analyzed with the Amira software, for a voxel-based morphometric analysis. RESULTS: We observed the presence of hypersignals with a significant enhancement in the structures analyzed in the group with LVNH, and greater volume in the lateral ventricles, presenting a larger size of the lesion on day PD96 and significantly reducing on day PD139. CONCLUSIONS: We found a cell rearrangement during the progression of the lesion, which could be the effect of the activation of immune cells.

OBJETIVO: Evaluar mediante resonancia magnética (RM) la progresión de la lesión en el modelo de esquizofrenia de lesión del núcleo del hipocampo ventral (LNHV). MÉTODO: Se realizaron RM en ratas Wistar macho, desde los 8 días posnatales hasta los 139 días, en animales con LNHV y sin lesión (sham). Las RM se realizaron con un equipo Variant de 7 T. Los datos se analizaron con el software Amira para un análisis de morfometría basada en vóxels. RESULTADOS: Observamos hiperseñales con un realce significativo en las estructuras analizadas en el grupo con LNHV, y mayor volumen en los ventrículos laterales, presentando un mayor tamaño de la lesión el día PD96 y significativamente reducido en el día PD139. CONCLUSIONES: Encontramos un reacomodo celular durante la progresión de la lesión, lo cual podría ser efecto de la activación de las células inmunitarias.

[Behavioral assessment of the "schizophrenia-like" phenotype in an animal model of neonatal lesion in the ventral hippocampus (NLVH) of young and adult rats]. / Evaluación conductual del fenotipo «esquizofrenia¼ en un modelo animal por lesión neonatal del hipocampo ventral en ratas juveniles y adultas.

Schizophrenia is a serious mental disorder that affects one in 100 people worldwide, and is characterized by distorted thoughts and perceptions. Several animal models have been developed, based primarily on the study of the mechanism of action of antipsychotics. In this paper we present a number of classic behavioral tests (memory, social interaction, and pre-pulse inhibition) associated with schizophrenia in young and adult animals with NLVH. The animal model of NLVH is a heuristic model that discriminates, by behavioral testing, the phenotype "schizophrenia-like" from other behavioral paradigms such as depression and anxiety, specifically in adult animals. The genomics study of this model promises to be an important source of candidate genes for schizophrenia in humans.