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The stable calcium (Ca) isotopes offer a minimally invasive method for assessing Ca balance in the body, providing a new avenue for research and clinical applications. In this study, we measured the Ca isotopic composition of soft tissues (brain, muscle, liver, and kidney), mineralized tissue (bone), and blood (plasma) from 10 mice (5 females and 5 males) with three different genetic backgrounds and same age (3 months old). The results reveal a distinctive Ca isotopic composition in different body compartments of mice, primally controlled by each compartment's unique Ca metabolism and genetic background, independent of sex. The bones are enriched in the lighter Ca isotopes (δ44/40Cabone = - 0.10 ± 0.55 ) compared to blood and other soft tissues, reflecting the preferential incorporation of lighter Ca isotopes through bone formation, while heavier Ca isotopes remain preferentially in blood. The brain and muscle are enriched in lighter Ca isotopes (δ44/40Cabrain = - 0.10 ± 0.53 ; δ44/40Camuscle = 0.19 ± 0.41 ) relative to blood and other soft tissues, making the brain the isotopically lightest soft tissues of the mouse body. In contrast, the kidney is enriched in heavier isotopes (δ44/40Cakidney = 0.86 ± 0.31 ) reflecting filtration and reabsorption by the kidney. This study provides important insight into the Ca isotopic composition of various body compartments and fluids.
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Potassium (K) is an essential electrolyte for cellular functions in living organisms, and disturbances in K+ homeostasis could lead to various chronic diseases (e.g. hypertension, cardiac disease, diabetes, and bone health). However, little is known about the natural distribution of stable K isotopes in mammals and their application to investigate bodily homeostasis and/or as biomarkers for diseases. Here, we measured K isotopic compositions (δ41K, per mil deviation of 41K/39K from the NIST SRM 3141a standard) of brain, liver, kidney, and red blood cells (RBCs) from 10 mice (five females and five males) with three different genetic backgrounds. Our results reveal that different organs and RBCs have distinct K isotopic signatures. Specifically, the RBCs have heavy K isotopes enrichment with δ41K ranging from 0.67 to 0.08, while the brains show lighter K isotopic compositions with δ41K ranging from -1.13 to -0.09 compared to the livers (δ41K = -0.12 ± 0.58) and kidneys (δ41K = -0.24 ± 0.57). We found that the K isotopic and concentration variability is mostly controlled by the organs, with a minor effect of the genetic background and sex. Our study suggests that the K isotopic composition could be used as a biomarker for changes in K+ homeostasis and related diseases such as hypertension, cardiovascular, and neurodegenerative diseases.
Assuntos
Hipertensão , Potássio , Masculino , Feminino , Animais , Camundongos , Isótopos , Isótopos de Potássio , Eritrócitos , MamíferosRESUMO
Based on our previously proposed modified Monte Carlo method, which is efficient to simulate the time-dependent polarized radiative transfer problem in an atmosphere-ocean model with a reflective/refractive interface, we further investigate the square pulse effect on the polarized radiative transfer in an atmosphere-ocean model. A short square pulse, with a duration of nanoseconds, is assumed to be incident at the top of the atmosphere. The polarized signals varying with time and directions are presented for the locations just above and below the atmosphere-water interface and at the bottom of the ocean, and effects of the incidence and disappearance of the external pulse on the Stokes vector components are analyzed. Results in this paper present the general distribution of square-pulse induced polarized signals and they are important for signal analysis in the field of remote sensing using nanosecond pulses.
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Time-dependent polarized radiative transfer in an atmosphere-ocean system exposed to external illumination is numerically investigated. The specular reflection and transmission effects based on the relative refractive index between the atmosphere and water are considered. A modified Monte Carlo (MMC) algorithm combined with time shift and superposition principle, which significantly improves the computational efficiency of the traditional Monte Carlo (TMC) method, is developed to simulate the time-dependent polarized radiative transfer process. The accuracy and computational superiority of the MMC for polarized radiative transfer in the atmosphere-ocean system are validated, and the time-resolved polarized radiative signals are discussed.
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To better understand the mechanism of Mg isotopic variation in magma systems, here we report high precision Mg isotopic data of 17 bulk rock samples including dunite, clinopyroxenite, hornblendite and gabbro and 10 pairs of dunite-hosted olivine and chromite separates from the well-characterized Alaskan-type Xiadong intrusion in NW China, which formed by continuous and high degree of lithological differentiation from mafic magmas. Chromite separates have highly variable δ26Mg values from -0.10 to 0.40, and are consistently heavier than coexisting olivine separates (-0.39 to -0.15). Both mineral δ26Mg values and the degrees of inter-mineral fractionation are well correlated with geochemical indicators of magma differentiation, indicating that these inter-sample and inter-mineral Mg isotope fractionations are caused by magma evolution. The δ26Mg values range from -0.20 to -0.02 in the dunite, -0.43 in the clinopyroxenite, -0.43 to -0.28 in the hornblendite, 0.18 in the chromite-bearing hornblendite, and -0.56 to -0.16 in the gabbro. The Mg isotopic variations in different types of rocks are closely related to fractional crystallization and accumulation of different proportions of oxides vs. silicates. Chromite crystallization and accumulation is the most important factor in controlling Mg isotope fractionation during the formation of the Xiadong intrusion. Compared to basaltic and granitic magmas, differentiation of the Alaskan-type intrusions occurs at a relatively high oxygen fugacity, which favors chromite crystallization and consequently significant Mg isotope fractionations at both mineral and whole-rock scales. Therefore, Mg isotope systematics can be used to trace the degree of magma differentiation and related-mineralization.
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We report Li isotopic compositions of olivine from the mantle sequence of the Luobusa ophiolite, southern Tibet. The olivine in the Luobusa ophiolite has Li concentrations from ~0.1 to 0.9 ppm and a broad range of δ(7)Li (+14 to -20). An inverse correlation of Li concentration and δ(7)Li in olivine from harzburgite suggests recent diffusive ingress of Li into the rock. Olivine from dunite enveloping podiform chromitites shows positive δ(7)Li values higher than those of MORB, whereas olivine from the chromitite has negative δ(7)Li values. Such variations are difficult to reconcile by diffusive fractionation and are thought to record the nature of the magma sources. Our results clearly indicate that the Luobusa chromitites formed from magmas with light Li isotopic compositions and that the dunites are products of melt-rock interaction. The isotopically light magmas originated by partial melting of a subducted slab after high degrees of dehydration and then penetrated the overlying mantle wedge. This study provides evidence for Li isotope heterogeneity in the mantle that resulted from subduction of a recycled oceanic component.
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Lithium elemental and isotopic compositions of olivines in peridotite xenoliths from Hebi in the North China Craton provide direct evidence for the highly variable δ(7)Li in Archean lithospheric mantle. The δ(7)Li in the cores of olivines from the Hebi high-Mg# peridotites (Fo > 91) show extreme variation from -27 to +21, in marked deviation from the δ(7)Li range of fresh MORB (+1.6 to +5.6) although the Li abundances of the olivines are within the range of normal mantle (1-2â ppm). The Li abundances and δ(7)Li characteristics of the Hebi olivines could not have been produced by recent diffusive-driven isotopic fractionation of Li and therefore the δ(7)Li in the cores of these olivines record the isotopic signature of the subcontinental lithospheric mantle. Our data demonstrate that abnormal δ(7)Li may be preserved in the ancient lithospheric mantle as observed in our study from the central North China Craton, which suggest that the subcontinental lithospheric mantle has experienced modification of fluid/melt derived from recycled oceanic crust.
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Polarized radiative transfer in a multilayer system is an important problem and has wide applications in various fields. In this work, a Monte Carlo (MC) model is developed to simulate polarized radiative transfer in a semitransparent arbitrary multilayer medium with different refractive indices in each layer. Two kinds of polarization mechanisms are considered: scattering by particles and reflection and refraction at the Fresnel surfaces or interfaces. The MC method has an obvious superiority in that complex mathematical derivations can be avoided in solving the polarization by Fresnel reflection and refraction in an arbitrary multilayer system. We define the vector radiative transfer matrix (VRTM), which describes the polarization characteristics of radiative transfer, and obtain four elements of Stokes vector using the VRTM. The results for the two-layer model by MC method are compared against those for coupled atmosphere-ocean model by the discrete-ordinate method available in the literature, which validates the correctness of the MC multilayer model of polarized radiative transfer. Finally, the results for three-layer, five-layer, and ten-layer models are presented in graphical form. Results show that in the multilayer system, total reflections occurring at the surfaces/interfaces have significant effects on the polarized radiative transfer, which causes abrupt changes or fluctuations like waves in the curves of the Stokes vector.
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Within a gradient-index medium, the radiative rays propagate in curved paths, which makes polarized states change continuously and the solution to the radiative transfer be thus more complex and difficult. In this paper, an arbitrary multilayer model is developed to approximately simulate vector (polarized) radiative transfer in a gradient-index plane-parallel medium. The gradient-index medium is divided into an arbitrary number of sublayers, and each sublayer has a uniform refractive index and two virtual Fresnel's interfaces where only transmission (refraction) is considered. Thus the polarization caused by the curved propagation of lights is approximated by that resulting from refraction on the interfaces. Radiative transfer with consideration of polarization caused by particle scattering and refraction (reflection) on the interfaces (surfaces) in the multilayer model is solved by the MC method. The grid independence of results obtained by the multilayer model for vector radiative transfer in gradient-index medium shows that the convergent solution of Stokes vector will be achieved provided that the sublayer number is large enough. The results for apparent emissivity of gradient-index medium and Stokes vector for two-layer medium are compared well with those in published literatures. Finally, we investigate polarized behaviors of radiative transfer in Rayleigh scattering slabs with linear and sinusoidal gradient indexes and present angular distributions of Stokes vector. Results show that total reflection inside the gradient-index medium resulting from the curved paths traveled by the photons affects greatly the angular distribution characteristics of Stokes vector.
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The characteristics of the transient and polarization must be considered for a complete and correct description of short-pulse laser transfer in a scattering medium. A Monte Carlo (MC) method combined with a time shift and superposition principle is developed to simulate transient vector (polarized) radiative transfer in a scattering medium. The transient vector radiative transfer matrix (TVRTM) is defined to describe the transient polarization behavior of short-pulse laser propagating in the scattering medium. According to the definition of reflectivity, a new criterion of reflection at Fresnel surface is presented. In order to improve the computational efficiency and accuracy, a time shift and superposition principle is applied to the MC model for transient vector radiative transfer. The results for transient scalar radiative transfer and steady-state vector radiative transfer are compared with those in published literatures, respectively, and an excellent agreement between them is observed, which validates the correctness of the present model. Finally, transient radiative transfer is simulated considering the polarization effect of short-pulse laser in a scattering medium, and the distributions of Stokes vector in angular and temporal space are presented.