RESUMO
The concentrations of C-reactive protein (CRP), serum amyloid A, haptoglobin (Hp) and α(1)-acid glycoprotein were measured in dogs with clinical signs of nasal disease and compared with those of healthy dogs in order to determine the expression of these proteins in cases of canine nasal disease. A significant difference (P<0.001) between the symptomatic group and the control group was found for both CRP and Hp. Among the animals with nasal disease, a significant intergroup difference (P<0.05) was found in the expression of Hp between dogs with aspergillosis and those with chronic rhinitis.
Assuntos
Doenças do Cão/sangue , Doenças Nasais/veterinária , Proteínas de Fase Aguda , Animais , Aspergilose/sangue , Aspergilose/imunologia , Aspergilose/veterinária , Proteína C-Reativa/metabolismo , Estudos de Casos e Controles , Doenças do Cão/imunologia , Cães , Feminino , Haptoglobinas/metabolismo , Masculino , Doenças Nasais/sangue , Doenças Nasais/imunologia , Rinite/sangue , Rinite/imunologia , Rinite/veterinária , Proteína Amiloide A Sérica/metabolismoRESUMO
Catalytic antibodies have created a new dimension in protein chemistry. In these studies it is particularly valuable to investigate systems for which natural enzymic catalysts are unknown. At Strathclyde we have examined several ways of preparing homochiral building blocks for organic synthesis. Antibodies that catalyse the Diels-Alder reaction have been characterized. The target reaction was the addition of acetoxybutadiene to N-substituted maleimides, a reaction that should give a pentafunctional homochiral building block. Catalytic antibodies can give insight into the mechanism of catalysis by proteins. We have investigated an adventitious hydrolytic antibody that cleaves activated esters. We have also shown that an antibody raised to ampicillin for analytical purposes catalyses hydrolysis of the beta-lactam ring.