RESUMO
The synthesis of a highly soluble triptycene end-capped indigo and its bay annulated derivative is reported. Both compounds have been studied by absorption and emission spectroscopy cyclic voltammetry, as well as theoretical calculations and compared to the parent indigo and bay annulated indigo. Besides a large improvement of solubility in organic solvents by the factor of approx. 70(!) the compounds also show a pronounced tendency to form crystals. Both properties, making these compounds promising electron acceptors for organic electronics.
RESUMO
Robust oligopeptides that mimic natural ion channels are attractive for use as molecular switches or model systems to study ion transport. Herein, we report octapeptides derived from aminobenzoic acid and l/d amino acids. Two of the alanine containing peptides were found to be most active and the peptide containing p-aminobenzoic acid was found to be most active (2.4 times its m-analog). Experimental studies indicate the peptides do not transport halides and transport alkali metal ions.
Assuntos
Ácido 4-Aminobenzoico/química , Ácido 4-Aminobenzoico/metabolismo , Oligopeptídeos/química , Oligopeptídeos/metabolismo , Cátions , Transporte de Íons/fisiologiaRESUMO
Ion transporters have been developed from acyclic octapeptides comprising L/D alanine and m-aminobenzoic acid. These octapeptides transport cations up to 3 times faster than their cyclic analog through lipid vesicles. Preliminary CD, XRD and computational studies allude to a 6-9 Å wide tetrameric ion channel as the active ion transporter.