Effects of Exercise Alone or Combined With Cognitive Training and Vitamin D Supplementation to Improve Cognition in Adults With Mild Cognitive Impairment: A Randomized Clinical Trial.

Importance: Exercise, cognitive training, and vitamin D may enhance cognition in older adults with mild cognitive impairment (MCI). Objective: To determine whether aerobic-resistance exercises would improve cognition relative to an active control and if a multidomain intervention including exercises, computerized cognitive training, and vitamin D supplementation would show greater improvements than exercise alone. Design, Setting, and Participants: This randomized clinical trial (the SYNERGIC Study) was a multisite, double-masked, fractional factorial trial that evaluated the effects of aerobic-resistance exercise, computerized cognitive training, and vitamin D on cognition. Eligible participants were between ages 65 and 84 years with MCI enrolled from September 19, 2016, to April 7, 2020. Data were analyzed from February 2021 to December 2022. Interventions: Participants were randomized to 5 study arms and treated for 20 weeks: arm 1 (multidomain intervention with exercise, cognitive training, and vitamin D), arm 2 (exercise, cognitive training, and placebo vitamin D), arm 3 (exercise, sham cognitive training, and vitamin D), arm 4 (exercise, sham cognitive training, and placebo vitamin D), and arm 5 (control group with balance-toning exercise, sham cognitive training, and placebo vitamin D). The vitamin D regimen was a 10 000 IU dose 3 times weekly. Main Outcomes and Measures: Primary outcomes were changes in ADAS-Cog-13 and Plus variant at 6 months. Results: Among 175 randomized participants (mean [SD] age, 73.1 [6.6] years; 86 [49.1%] women), 144 (82%) completed the intervention and 133 (76%) completed the follow-up (month 12). At 6 months, all active arms (ie, arms 1 through 4) with aerobic-resistance exercise regardless of the addition of cognitive training or vitamin D, improved ADAS-Cog-13 when compared with control (mean difference, -1.79 points; 95% CI, -3.27 to -0.31 points; P = .02; d = 0.64). Compared with exercise alone (arms 3 and 4), exercise and cognitive training (arms 1 and 2) improved the ADAS-Cog-13 (mean difference, -1.45 points; 95% CI, -2.70 to -0.21 points; P = .02; d = 0.39). No significant improvement was found with vitamin D. Finally, the multidomain intervention (arm 1) improved the ADAS-Cog-13 score significantly compared with control (mean difference, -2.64 points; 95% CI, -4.42 to -0.80 points; P = .005; d = 0.71). Changes in ADAS-Cog-Plus were not significant. Conclusions and Relevance: In this clinical trial, older adults with MCI receiving aerobic-resistance exercises with sequential computerized cognitive training significantly improved cognition, although some results were inconsistent. Vitamin D supplementation had no effect. Our findings suggest that this multidomain intervention may improve cognition and potentially delay dementia onset in MCI. Trial Registration: ClinicalTrials.gov Identifier: NCT02808676.

Multiple routes to help you roam: A comparison of training interventions to improve cognitive-motor dual-tasking in healthy older adults.

Cognitive-motor dual-tasking is a complex activity that predicts falls risk and cognitive impairment in older adults. Cognitive and physical training can both lead to improvements in dual-tasking; however, less is known about what mechanisms underlie these changes. To investigate this, 33 healthy older adults were randomized to one of three training arms: Executive function (EF; n = 10), Aerobic Exercise (AE; n = 10), Gross Motor Abilities (GMA; n = 13) over 12 weeks (1 h, 3×/week). Single and dual-task performance (gait speed, m/s; cognitive accuracy, %) was evaluated before and after training, using the 2-back as concurrent cognitive load. Training arms were designed to improve cognitive and motor functioning, through different mechanisms (i.e., executive functioning - EF, cardiorespiratory fitness - CRF, and energy cost of walking - ECW). Compared to baseline, we observed few changes in dual-task gait speed following training (small effect). However, dual-task cognitive accuracy improved significantly, becoming facilitated by walking (large effect). There were no differences in the magnitude of improvements across training arms. We also found that older adults with lower cognitive ability (i.e., MoCA score < 26; n = 14) improved more on the dual-task cognitive accuracy following training, compared to older adults with higher cognitive ability (i.e., MoCA ≥26; n = 18). Taken together, the results suggest that regardless of the type of intervention, training appears to strengthen cognitive efficiency during dual-tasking, particularly for older adults with lower baseline cognitive status. These gains appear to occur via different mechanisms depending on the form of intervention. Implications of this research are paramount, as we demonstrate multiple routes for improving cognitive-motor dual-tasking in older adults, which may help reduce risk of cognitive impairment.

Impact of tapering and proactive recovery on young elite rugby union players' repeated high intensity effort ability.

To assess the effects of a taper combined with proactive recovery on the repeated high intensity effort (RHIE) of elite rugby union players, and the possible interaction of pre-taper fatigue and sleep. Eighteen players performed a 3-week intensive training block followed by a 7-day exponential taper combined with a multicomponent recovery strategy. Following the intervention, players were divided into 3 groups (Normal Training: NT, Acute Fatigue: AF or Functional Overreaching: F-OR) based on their readiness to perform prior to the taper. Total sprint time [TST], percentage decrement [%D] and the number of sprints ≥90% of the best [N90] were analyzed to assess performance during a RHIE test. Subjective sleep quality was assessed through the Pittsburg Sleep Quality Index (PSQI) and the Epworth Sleepiness Scale (ESS). No improvement in TST was reported in either NT or F-OR after the taper, whereas AF tended to improve (-1.58 ± 1.95%; p > 0.05; g = -0.20). F-OR players reported baseline PSQI and ESS indicative of sleep disturbance (6.2 ± 2.2 and 10.6 ± 5.4, respectively). AF displayed a small impairment in PSQI during intensive training (11.5 ± 80.6%; p > 0.05; g = 0.20), which was reversed following the taper (-34.6 ± 62.1%; p > 0.05; g = -0.73). Pre-taper fatigue precluded the expected performance benefits of the combined taper and recovery intervention, likely associated with a lack of strictly controlled intensive training block. Poor sleep quality before the intensive training period appeared to predispose the players to developing functional overreaching.

Preconditioning Activities to Enhance Repeated High-Intensity Efforts in Elite Rugby Union Players.

PURPOSE: To assess the effect of a rugby-specific high-intensity interval-training (HIITRugby) protocol on the repeated high-intensity-effort ability of young elite rugby union players and to verify the influence of 2 preconditioning sequences composed either of physical contacts (ie, tackles) or of additional runs on the magnitude of improvement. METHOD: Fourteen players (19 [1] y; 183.5 [8.6] cm; 95.6 [15.6] kg) underwent an HIITRugby protocol, consisting of 7 supervised training sessions over 4 weeks, each session including 3 or 4 sets of 1 to 2 minutes with 1-minute recovery. Prior to HIITRugby training, players underwent a preconditioning contact sequence or a preconditioning running sequence, to assess their influence on subsequent interval-training sessions. RESULTS: The overall group showed a moderate improvement in total sprint time, sprints ≥90% of the best, and 20-m sprint (-3.91% [2.68%], P = .0002; 74.6% [123.7%], P = .012; -3.22% [3.13%], P = .003, respectively) and a large improvement in percentage decrement (-23.1% [20.5%], P = .005) following the 4-week training block. Relative improvements were similar between groups in total sprint time, 20-m sprint, and perceived difficulty, but the preconditioning running-sequence group exhibited a larger magnitude of gains in percentage decrement (-28.6% [20.2%] vs -17.6% [20.7%]; effect size = -1.01 vs -0.73). CONCLUSION: An HIITRugby training block was effective to improve repeated high-intensity-effort ability. A preconditioning contact sequence prior to HIITRugby can reduce subsequent long-interval running activity, which may attenuate the improvement of repeated high-intensity-effort indices related to the aerobic system.

A Comparison of the Effect of Physical Activity and Cognitive Training on Dual-Task Performance in Older Adults.

OBJECTIVES: Studies suggest that cognitive training and physical activity can improve age-related deficits in dual-task performances. However, both of these interventions have never been compared in the same study. This article investigates the improvement in dual-task performance in 2 types of exercise training groups and a cognitive training group and explores if there are specific dual-task components that are more sensitive or more likely to improve following each type of training. METHODS: Seventy-eight healthy inactive participants older than the age of 60 (M = 69.98, SD = 5.56) were randomized to one of three 12-week training programs: aerobic training (AET) = 26, gross motor abilities (GMA) = 27, and cognition (COG) = 25. Before and after the training program, the participants underwent physical fitness tests, and cognitive evaluations involving a computerized cognitive dual task. The AET consisted of high- and low-intensity aerobic training, the GMA of full-body exercises focusing on agility, balance, coordination, and stretching, and the COG of tablet-based exercises focusing on executive functions. RESULTS: Repeated-measures analysis of variance on reaction time data revealed a group × time interaction (F(2,75) = 11.91, p < .01) with COG having the greatest improvement, followed by a significant improvement in the GMA group. Secondary analysis revealed the COG to also improve the intraindividual variability in reaction time (F(1,24) = 8.62, p < .01), while the GMA improved the dual-task cost (F(1,26) = 12.74, p < .01). DISCUSSION: The results show that physical and cognitive training can help enhance dual-task performance by improving different aspects of the task, suggesting that different mechanisms are in play.

Bridging the Gap between Research and the Community: Implementing Physical and Cognitive Interventions to Improve Spontaneous Walking Speed in Older Adults.

The application of interventions to enhance mobility in ecological settings remain understudied. This study was developed to evaluate the feasibility of training methods in a community centre and to evaluate their impact on mobility outcomes. Fifty-four participants were randomized to one of three 12-week training programs (three times/week): aerobic (AE), gross motor abilities (GMA) or cognitive (COG). Feasibility was evaluated by calculating adherence, feedback from participants and long-term participation. The impact of these interventions on mobility was assessed by comparing pre- and post-program on Timed-up-and-go (TUG) and spontaneous walking speed (SWS) performances. Results showed relatively high rates of adherence (85.1%) and long-term participation (66.7%), along with favorable feedbacks. SWS significantly improved in COG (0.10 ± 0.11 m.s-1; p = 0.004) and AE (0.06 ± 0.11 m.s-1; p = 0.017) groups, and TUG performance was maintained in all groups. Results of this feasibility study demonstrated successful implementation of physical and cognitive training programs, encouraging the development of real-world applications.

Sport-Specific Agility and Change of Direction in Water Polo: The Reliability and Validity of Two Newly Developed Tests.

ABSTRACT: Dong, L, Paradelo, D, Delorme, A, Oliveira, J, Parillo, B, Croteau, F, Romeas, T, Dubé, E, Bieuzen, F, Billaut, F, and Berryman, N. Sport-specific agility and change of direction in water polo: The reliability and validity of two newly developed tests. J Strength Cond Res 35(12S): S111-S118, 2021-There is a gap in water-based agility testing that considers both the change-of-direction (COD) and perceptive-reactive components of agility. This study sought to develop easily implementable, sport-specific in-water agility tests for water polo and to verify the reliability and validity of these new tests: the in-water Stop and Go (SG) and Jump and Go (JG). Female water polo athletes at the Senior (n = 12, age = 22.1 ± 2.1 years), Junior (n = 19, age = 18.5 ± 1.0 years), and Youth (n = 11, age = 16.5 ± 0.8 years) national levels performed 3 trials of each of the SG, JG, and the existing Functional Test for Agility Performance (FTAP). Senior athletes performed an additional experimental session to assess reliability parameters. Relative reliability for agility and COD versions of the SG and JG was high or very high (intraclass correlation coefficient [ICC] = 0.76-0.95). For construct validity analyses, significant between-group differences for each of the new tests (p < 0.05) were found. In contrast, the FTAP was moderately reliable (ICC = 0.57) and was unsuccessful in discriminating between playing levels. Considering the favorable metrological properties of the SG and JG, their fidelity to in-game demands, and their accessible setups, these new tests represent viable options to implement at grassroots and elite levels for the assessment and training of water polo-specific agility.

Assessment of the Relationship Between Executive Function and Cardiorespiratory Fitness in Healthy Older Adults.

Associations between cardiorespiratory fitness and brain health in healthy older adults have been reported using a variety of cardiorespiratory fitness estimates (CRFe). Using commonly used methods to determine CRF, we assessed the relationship between CRFe and executive function performance. Healthy older adults (n = 60, mean age 68 years, 77% women), underwent three CRF tests: a Maximal Graded Exercise Test performed on a cycle ergometer, the Rockport Fitness Walking Test, and a Non-Exercise Prediction Equation. Executive function was assessed by a computerized cognitive assessment using an N-Back task (updating cost) and a Stroop task (interference cost, global and local switch cost). Multiple hierarchical regression analyses were conducted to assess the relationship between different CRFe and executive function performance. Regardless of age and education, cardiorespiratory fitness estimated from the Maximal Graded Exercise Test and the Rockport Fitness Walking Test was significantly associated with the global switch cost. All CRFe were associated with the interference cost. No association was observed between CRFe and local switching costs or the updating costs. In the present study, not all subcomponents of executive function were related to CRFe. Interestingly, the executive functions that were associated with CRFe are those that are known to be the most affected by aging.

Cardiorespiratory fitness and prefrontal cortex oxygenation during Stroop task in older males.

AIM: The aim of the current study was to assess whether executive function and prefrontal oxygenation are dependent on fitness level and age in older adults. METHODS: Twenty-four healthy males aged between 55 and 69 years old were recruited for this study. They were stratified by age, leading to the creation of two groups: 55-60 years old and 61-69 years old. A median split based on CRF created higher- and lower-fit categories of participants. Cerebral oxygenation was assessed using functional near-infrared spectroscopy (fNIRS) during a computerized Stroop task. Accuracy (% of correct responses) and reaction times (ms) were used as behavioural indicators of cognitive performances. Changes in oxygenated (∆[HbO2]) and deoxygenated (∆[HHb]) hemoglobin were measured to capture neural changes. Repeated measures ANOVAs (CRF × Age × Stroop conditions) were performed to test the null hypothesis of an absence of interaction between CRF, Age and executive performance. RESULTS: We also found an interaction between CRF and age on reaction times (p = .001), in which higher fitness levels were related to faster reaction times in the 61-69 year olds but not in the 55-60 year olds. Regarding ΔHHb, the ANOVA revealed a main effect of CRF in the right PFC (p = .04), in which higher-fit participants had a greater Δ[HHb] than the lower-fit (d = 1.5). We also found fitness by age interaction for Δ[HHb] in the right PFC (p = .04). CONCLUSION: Our results support the positive association of CRF on cerebral oxygenation and Stroop performance in healthy older males. They indicated that high-fit individuals performed better in the 61-69 year olds group, but not in the 55-60 years old group. We also observed a greater PFC oxygenation change (as measured by Δ[HHb]) in the high-fit individuals.

Fitness Determinants of Repeated High-Intensity Effort Ability in Elite Rugby Union Players.

PURPOSE: To investigate the relationship between physical fitness and repeated high-intensity effort (RHIE) ability in elite rugby union players, depending on playing position. METHOD: Thirty-nine players underwent a fitness testing battery composed of a body composition assessment, upper-body strength (1-repetition maximum bench press and 1-repetition maximum bench row), lower-body strength (6-repetition maximum back squat), and power (countermovement jump, countermovement jump with arms, and 20-m sprint), as well as aerobic fitness (Bronco test) and RHIE tests over a 1-week period. Pearson linear correlations were used to quantify relationships between fitness tests and the RHIE performance outcomes (total sprint time [TST] and percentage decrement [%D]). Thereafter, a stepwise multiple regression model was used to verify the influence of physical fitness measures on RHIE ability. RESULTS: TST was strongly to very strongly associated to body fat (BF, r = .82, P < .01), the 20-m sprint (r = .86, P < .01), countermovement jump (r = -.72, P < .01), and Bronco test (r = .90, P < .01). These fitness outcomes were related to %D, with moderate to strong associations (.82 > ∣r∣ > .54, P < .01). By playing position, similar associations were observed in forwards, but RHIE ability was only related to the 20-m sprint in backs (r = .53, P < .05). The RHIE performance model equations were TST = 13.69 + 0.01 × BF + 0.08 × Bronco + 10.20 × 20 m and %D = -14.34 + 0.11 × BF +0.18 × Bronco - 9.92 × 20 m. These models explain 88.8% and 68.2% of the variance, respectively. CONCLUSION: Body composition, lower-body power, and aerobic fitness were highly related with RHIE ability. However, backs expressed a different profile than forwards, suggesting that further research with larger sample sizes is needed to better understand the fitness determinants of backs' RHIE ability.

A comparison of physical exercise and cognitive training interventions to improve determinants of functional mobility in healthy older adults.

OBJECTIVES: Mobility is a complex but crucial clinical outcome in older adults. Past observational studies have highlighted that cardiorespiratory fitness (CRF), energy cost of walking (ECW), and cognitive switching abilities are associated with mobility performance, making these key determinants of mobility intervention targets to enhance mobility in older adults. The objective of this study was to compare, in the same design, the impact of three training methods - each known to improve either CRF, ECW, or cognitive switching abilities - on mobility in healthy older adults. METHODS: Seventy-eight participants (69.28 ± 4.85yo) were randomly assigned to one of three twelve-week interventions: Aerobic Exercise (AE; n = 26), Gross Motor Abilities (GMA; n = 27), or Cognitive (COG; n = 25) training. Each intervention was designed to improve one of the three key determinants of mobility (CRF, ECW, and cognitive switching). Primary outcomes (usual gait speed, and TUG performance) and the three mobility determinants were measured before and after the intervention. RESULTS: Repeated-measures ANOVAs showed a time effect for TUG performance (F(1,75) = 14.92, p < .001): all groups equally improved after the intervention (ΔTUGpost-pre, in seconds, with 95% CI: AE = -0.44 [-0.81 to -0.08]; GMA = -0.60 [-1.10 to -0.10]; COG = -0.33 [-0.71 to 0.05]). No significant between group differences were observed. CRF was improved in the AE group only (Hedges' G = 0.27, small effect), ECW and cognitive switching improved the most in the GMA (Hedges' G = -0.78, moderate effect) and COG groups (Hedges' G = -1.93, large effect) respectively. Smaller improvements in ECW were observed following AE and COG trainings (Hedges' G: AE = -0.39, COG = -0.36, both small effects) as well as in cognitive switching following AE and GMA training (Hedges' G: AE = -0.42, GMA = -0.21, both small effects). DISCUSSION: This study provides further support to the notion that multiple interventional approaches (aerobic, gross motor exercise, or cognitive training) can be employed to improve functional mobility in older adults, giving them, and professionals, more options to promote healthy ageing.

Tapering and Repeated High-Intensity Effort Ability in Young Elite Rugby Union Players: Influence of Pretaper Fatigue Level.

PURPOSE: To assess the effects of a short-term taper on the ability to perform repeated high-intensity efforts, depending on players' fatigue level following an intensive training block. METHOD: After a 3-day off-season camp, 13 players followed the same 3-week preseason training block followed by a 7-day exponential taper. Performance was assessed by a repeated high-intensity effort test before and after the taper. Total sprint time, percentage of decrement, and the number of sprints equal to or higher than 90% of the best sprint were retained for analysis. Players were a posteriori classified in normal training or acute fatigue groups based on their readiness to perform prior to the taper, assessed through the magnitude of difference in psychological (Profile of Mood State Questionnaire), cardiovascular (submaximal constant-duration cycling), and neuromuscular (countermovement jump) tests between the preintensive and postintensive training blocks. RESULTS: Training load declined by 55% (9%) during the taper (P = .001, g = -2.54). The overall group showed a small improvement in total sprint time (-3.40% [3.90%], P = .04, g = -0.39) following the taper. Relative changes tended to be higher in the acute fatigue compared with the normal training group (-5.07% [4.52%] vs -1.45% [1.88%], respectively; P = .08; d = 1.01). No taper-induced improvement was observed in percentage of decrement or number of sprints equal to or higher than 90% of the best sprint. CONCLUSION: A 7-day taper consisting of 55% training load reduction improved repeated high-intensity effort performance in young elite rugby union players. Pretaper level of fatigue seems to be a key determinant in the taper supercompensation process, as acutely fatigued players at the end of the intensive training block tended to benefit more from the taper.

Effects of tapering on neuromuscular and metabolic fitness in team sports: a systematic review and meta-analysis.

Purpose: To assess the effects of a taper strategy on neuromuscular and metabolic fitness in team sport athletes, through a systematic review and meta-analysis. Method: To be included in this meta-analysis, studies had to involve competitive team sport athletes and a tapering intervention providing details about the procedures used to decrease the training load, as well as competition or field-based criterion performance and all necessary data to calculate effect sizes. Four databases were searched according to these criteria, which led to the identification of 895 potential studies and the subsequent inclusion of 14 articles. Independent variables were training intensity, volume and frequency, as well as the pattern of taper and its duration. The dependent variable was performance obtained in various neuromuscular and metabolic tests. Results: There was limited evidence of a moderate taper-induced improvement in repeated sprint ability (Standardized Mean Difference (SMD) (95%IC;I2) = 0.41 (0.26-0.55;0%)) and moderate evidence of a moderate increase in maximal power (SMD (95%IC;I2) = 0.44 (0.32-0.56;15%)), change of direction speed (SMD (95%IC;I2) = 0.38 (0.15-0.60;28%)) and maximal oxygen uptake (SMD (95%IC;I2) = 0.76 (0.43-1.09;37%)). Conclusion: Tapering is an effective training strategy to improve maximal power, maximal oxygen uptake, repeated sprint ability and change of direction speed in team sports. However, the literature lacks studies using various tapering strategies to compare their effectiveness and make evidence-based recommendations. Future original studies should focus on this major issue.

Synergistic Effects of Cognitive Training and Physical Exercise on Dual-Task Performance in Older Adults.

BACKGROUND: Studies report benefits of physical exercise and cognitive training to enhance cognition in older adults. However, most studies did not compare these interventions to appropriate active controls. Moreover, physical exercise and cognitive training seem to involve different mechanisms of brain plasticity, suggesting a potential synergistic effect on cognition. OBJECTIVE: This study investigated the synergistic effect of cognitive training and aerobic/resistance physical exercise on dual-task performance in older adults. Intervention effects were compared to active controls for both the cognitive and the exercise domain. METHOD: Eighty-seven older adults completed one of 4 different combinations of interventions, in which computer lessons was active control for cognitive training and stretching/toning exercise control for aerobic/resistance training: (a) cognitive dual-task training and aerobic/resistance training (COG+/AER+), (b) computer lessons and aerobic/resistance training (COG-/AER+), (c) cognitive dual-task training and stretching/toning exercises (COG+/AER-), and (d) computer lessons and stretching/toning exercises (COG-/AER-). The primary outcome was performance in an untrained transfer dual task. Stepwise backward removal regression analyses were used to predict pre- versus post-test changes in groups that have completed the dual-task training, aerobic/resistance or both interventions. RESULTS: Participation in AER+ did not predict improvement in any dual-task outcomes. Participation in COG+ predicted reduction in dual-task cost and participation in COG+/AER+ predicted reduction in task-set cost. DISCUSSION: Results suggest that the combination of cognitive and physical training protocols exerted a synergistic effect on task-set cost which reflects the cost of maintaining multiple response alternatives, whereas cognitive training specifically improved dual-task cost, which reflects the ability of synchronizing concurrent tasks.

Effects of Short-Term Concurrent Training Cessation on the Energy Cost of Running and Neuromuscular Performances in Middle-Distance Runners.

Evidence supports the implementation of concurrent strength and running training, within the same mesocycle, to improve performances in middle- and long-distance events. However, very little is known about the effects of concurrent training cessation. The purpose of this investigation was to describe the effects of 4 weeks of explosive strength training cessation after an 8-week concurrent training protocol. Eight runners completed this study, which first included either plyometric (n = 4) or dynamic weight training (n = 4) in addition to the usual running regimen. Explosive strength training was thereafter interrupted for 4 weeks, during which running sessions were maintained. Participants were tested at baseline, after concurrent training and after concurrent training cessation. The results suggest that the energy cost of running improvements observed after the intervention (-5.75%; 95% CI = -8.47 to -3.03) were maintained once explosive strength training was interrupted (-6.31%; 95% CI = -10.30 to -2.32). The results also suggest that neuromuscular performances were maintained after 4 weeks of concurrent training cessation, especially when tests were specific to the training intervention. Furthermore, a 3000m time trial revealed a similar pattern, with improvements after the concurrent mesocycle (-2.40%; 95% CI = -4.65 to -0.16) and after concurrent training cessation (-4.43%; 95% CI = -6.83 to -2.03). Overall, only trivial changes were observed for aerobic endurance and V˙O2peak. Together, these results suggest that short-term explosive strength training cessation might be beneficial and could be considered as a taper strategy for middle-distance runners. However, coaches and athletes must interpret these results cautiously considering the study's low sample size and the very limited available literature in this domain.

Mind the Rhythm: ECG QT Dispersion and Cognition in Healthy Older Adults.

BACKGROUND: Autonomic function has been linked to cognitive abilities in aging. Even in non-clinical states, a certain variability in heart rhythm regulation can be measured with QT dispersion (QTcD), an ECG marker of ventricular repolarization which has been linked to autonomic function and cardiovascular health. QTcD has been shown to be higher in individuals with mild cognitive impairment, and the highest in individuals with Alzheimer's disease. The goal of this study was to see if QTcD is associated with cognitive performance in healthy individuals. METHODS: Sixty-three healthy inactive older adults (> 60 years) completed an extensive cognitive assessment (including inhibition, divided attention, updating, working memory, and processing speed), a physical fitness assessment, and underwent a resting ECG. RESULTS: After controlling for age, sex, and education, QTcD significantly predicted global cognition (MoCA) scores (R 2 = 0.17, F ( 4 . 58 ) = 3.00, p < 0.03, ß = -0.36). Exploratory analysis on the MoCA subcomponents revealed a significant association between the visual/executive subcomponent and QTcD (R 2 = 0.12, F (1 .6 1) = 7.99, p < 0.01, ß = -0.34). In individuals with high QTcD, QTcD values were linked to executive functions (R 2 = 0.37), processing speed (R 2 = 0.34), and dual-task performances (R 2 = 0.47). No significant associations were found within the low QTcD group. CONCLUSION: This study shows an association between ventricular repolarization (QTcD) and cognitive performance, in particular speed and executive functions, in healthy older adults. The results provide further support for linking autonomic heart regulation and age-related cognitive changes, and suggest that deviations on ECG, even within-normal range, could help detect early cognitive deficits.

Sex-moderated association between body composition and cognition in older adults.

BACKGROUND: Some studies have reported an association between body composition and cognition in older adults, but underlying mechanisms and physiological factors remain poorly understood. Moreover, sex-related differences in metabolic health and age-related cognitive decline have gained major interest lately. The present study investigated the potential moderating effect of sex on the relationship between body composition and cognition in older adults. METHODS: Global cognition, assessed by the Montreal Cognitive Assessment (MoCA), and body composition, measured using dual-energy x-ray absorptiometry (DXA), were analyzed in 155 women and 65 men aged 60 years old or more. Moderation analyses were computed to determine if sex moderates the effect of the different body composition parameters on the MoCA while controlling for the body mass index and the level of education of the participants. RESULTS: Sex moderated the association between total lean mass, trunk lean mass, arms lean mass, and the MoCA score. These body composition parameters were positively associated with cognition only in men. Fat mass was not associated with cognition in any sex. CONCLUSION: Overall, higher lean mass and in particular trunk and arms lean mass was associated with higher cognitive abilities in older men. Longitudinal studies or intervention studies are needed to further identify physiological mechanisms that sustain the relationship between lean mass and cognition.

Reliability of a Repeated High-Intensity Effort Test for Elite Rugby Union Players.

This study aimed to adapt a repeated high-intensity effort (RHIE) test to the rugby union physical demands and assess both sprint time and tackle indices reliability. Following a familiarization session, sixteen elite rugby union players completed two RHIE tests consisting of 12 × 20 m sprint + tackle. Total sprint time and total g-force during tackling, average sprint time and average g-force as well as percentage decrementsprint time and percentage decrementtackle were considered for the analysis. Sprint time indices showed high to very high absolute and relative reliability (intraclass coefficient correlation (ICC) = 0.95, Standard Error Measurement (SEM) = 1.30%; ICC = 0.95, SEM = 1.44%; ICC = 0.73, SEM = 23.0%, for total sprint time, average sprint time and percentage decrementsprint time, respectively). Tackle indices showed moderate to high reliability (ICC = 0.54, SEM = 16.5%; ICC = 0.61, SEM = 15.6%; ICC = 0.71, SEM = 12.3%, for total g-force, average g-force and percentage decrementtackle, respectively). The RHIE test provides reliable measures of sprint time and tackle indices. Tackle indices should be used as a validation criterion of the test, whereas total time should be considered as the test final result.

Effects of an 8-week training cessation period on cognition and functional capacity in older adults.

BACKGROUND: Multiple types of exercise interventions have been described as effective methods for improving cognition and mobility in older adults. In addition to combined strength and aerobic training, gross motor activities have shown benefits. However, adherence to exercise is a challenge, which may bring about periods of training cessation. Importantly, short-term training cessation may lead to a loss of fitness adaptations. The effects of training cessation on cognition and functional capacity are not well known, especially within the context of dual-tasking in older adults. OBJECTIVES: We examined the effects of an 8-week training cessation period on cognition (executive functioning (EF) in single (ST) and dual-task (DT)) and functional capacity (10 m Walk and 6 Minute Walk Test) of healthy older adults, after one of three training interventions: combined lower body strength and aerobic, combined upper body strength and aerobic, or gross motor activities. MATERIALS AND METHODS: Forty older adults (70.5 ± 5.5 years, 67.5% F) participated in training sessions, 3×/week for 8 weeks prior to training cessation. Pre (T0), post (T1) and follow-up (post-cessation, T2) measures of EF (performance in inhibition and updating/working memory indices of the Random Number Generation task) in ST and DT (treadmill walking at 0.67 m·s-1, 1.11 m·s-1, and 1.56 m·s-1), and functional capacity were assessed. Changes in ST and DT as well as functional capacity tests were analyzed using two-way ANOVAs (time ∗ group) with repeated measures for the time factor (T0, T1 and T2). RESULTS: Improvements in inhibition indices were observed in ST for all time comparisons (T0-T1, T1-T2 and T0-T2). Inhibition in DT improved from T0-T2 and from T1-T2. Working memory declined from T0-T2 and from T1-T2. Functional capacity performance was maintained from T1-T2 (small improvement from T0-T1 and from T0-T2). DISCUSSION: Performances in inhibition were maintained or improved after cessation of training. We found no interaction between training groups, whatever the condition, indicating similar training cessation effects regardless of the intervention. CONCLUSIONS: Multiple types of exercise interventions may lead to positive benefit to inhibition and functional capacity in older adults, and it may also be possible to retain these benefits after a short cessation period.

Cerebral Oxygenation Reserve: The Relationship Between Physical Activity Level and the Cognitive Load During a Stroop Task in Healthy Young Males.

Introduction: Many studies have reported that regular physical activity is positively associated with cognitive performance and more selectively with executive functions. However, some studies reported that the association of physical activity on executive performance in younger adults was not as clearly established when compared to studies with older adults. Among the many physiological mechanisms that may influence cognitive functioning, prefrontal (PFC) oxygenation seems to play a major role. The aim of the current study was to assess whether executive function and prefrontal oxygenation are dependent on physical activity levels (active versus inactive) in healthy young males. Methods: Fifty-six healthy young males (22.1 ± 2.4 years) were classified as active (n = 26) or inactive (n = 30) according to the recommendations made by the World Health Organization (WHO) and using the Global Physical Activity Questionnaire (GPAQ). Bilateral PFC oxygenation was assessed using functional near-infrared spectroscopy (fNIRS) during a computerized Stroop task (which included naming, inhibition, and switching conditions). Accuracy (% of correct responses) and reaction times (ms) were used as behavioural indicators of cognitive performances. Changes in oxygenated (∆HbO2) and deoxygenated (∆HHb) hemoglobin were measured to capture neural changes. Several two-way repeated measures ANOVAs (Physical activity level x Stroop conditions) were performed to test the null hypothesis of an absence of interaction between physical activity level and executive performance in prefrontal oxygenation. Results: The analysis revealed an interaction between physical activity level and Stroop conditions on reaction time (p = 0.04; ES = 0.7) in which physical activity level had a moderate effect on reaction time in the switching condition (p = 0.02; ES = 0.8) but not in naming and inhibition conditions. At the neural level, a significant interaction between physical activity level and prefrontal oxygenation was found. Physical activity level had a large effect on ΔHbO2 in the switching condition in the right PFC (p = 0.04; ES = 0.8) and left PFC (p = 0.02; ES = 0.96), but not in other conditions. A large physical activity level effect was also found on ΔHHb in the inhibition condition in the right PFC (p < 0.01; ES = 0.9), but not in the left PFC or other conditions. Conclusion: The results of this cross-sectional study indicate that active young males performed better in executive tasks than their inactive counterparts and had a larger change in oxygenation in the PFC during these most complex conditions.