Diagnostic accuracy of shear wave elastography for endometrial cancer: A meta-analysis.

BACKGROUND: This meta-analysis aimed to identify the accuracy of shear wave elastography (SWE) in the diagnosis of endometrial cancer (EC). METHODS: We searched the PubMed, Cochrane Library, and chinese biomedical literature database from inception to September 30, 2022. Meta-analysis was conducted using STATA version 14.0 and Meta-Disc version 1.4 software. We calculated summary statistics for sensitivity (Sen), specificity (Spe), positive and negative likelihood ratio (LR+/LR-), diagnostic odds ratio (DOR), and receiver operating characteristic (SROC) curves. RESULTS: Eight studies that met all the inclusion criteria were included in this meta-analysis. A total of 432 patients with EC and 548 with benign endometrial lesions were assessed. All endometrial lesions were histologically confirmed by SWE. The pooled Sen was 0.91 (95% confidence interval [CI] = 0.83-0.95); the pooled Spe was 0.90 (95% CI = 0.86-0.93); the pooled LR+ was 9.10 (95% CI = 6.20-13.35); the pooled negative LR- was 0.10 (95% CI = 0.05-0.20); the pooled DOR of SWE in the diagnosis of EC was 90.73 (95% CI = 36.62-804.5). The area under the SROC curve was 0.95 (95% CI = 0.93-0.97). No evidence of publication bias was found (t = 0.98, P = .37). CONCLUSION: Our meta-analysis indicates that SWE may have high diagnostic accuracy in the differential diagnosis of benign and malignant endometrial lesions. Thus, SWE may be a useful tool for the diagnosis of EC.

Ultrasonic S-Detect mode for the evaluation of thyroid nodules: A meta-analysis.

OBJECTIVES: This meta-analysis aimed to evaluate the value of ultrasonic S-Detect mode for the evaluation of thyroid nodules. METHODS: We searched PubMed, Cochrane Library, and Chinese biomedical databases from inception to August 31, 2021. Meta-analysis was conducted using STATA version 14.0 and Meta-Disc version 1.4 software. We calculated the summary statistics for sensitivity (Sen), specificity (Spe), summary receiver operating characteristic curve, and the area under the curve, and compared the area under the curve between ultrasonic S-Detect mode and thyroid imaging report and data system (TI-RADS) for the diagnosis of thyroid nodules. As a systematic review summarizing the results of previous studies, this study does not need the informed consent of patients or the approval of the ethics review committee. RESULTS: Fifteen studies that met all inclusion criteria were included in this meta-analysis. A total of 924 thyroid malignant nodules and 1228 thyroid benign nodules were assessed. All thyroid nodules were histologically confirmed after examination. The pooled Sen and Spe of TI-RADS were 0.89 (95% confidence interval [CI] = 0.85-0.91) and 0.85 (95% CI = 0.78-0.90), respectively; the pooled Sen and Spe of S-Detect were 0.88 (95% CI = 0.85-0.90) and 0.73 (95% CI = 0.63-0.81), respectively. The areas under the summary receiver operating characteristic curve of TI-RADS and S-Detect were 0.9370 (standard error [SE] = 0.0110) and 0.9128 (SE = 0.0147), respectively, between which there was no significant difference (Z = 1.318; SE = 0.0184; P = .1875). We found no evidence of publication bias (t = 0.36, P = .72). CONCLUSIONS: Our meta-analysis indicates that ultrasonic S-Detect mode may have high diagnostic accuracy and may have certain clinical application value, especially for young doctors.

Comparation of magnetic resonance hysterosalpingography and hysterosalpingosonography for the assessment of fallopian tubal occlusion of female infertility: A protocol for systematic review and meta-analysis.

OBJECTIVE: To evaluate the diagnostic performance of magnetic resonance hysterosalpingography (MR-HSG) for fallopian tubal occlusion in the context of female infertility when compared to the diagnostic performance of hysterosalpingosonography in evaluation of fallopian tubal occlusion of female infertility. METHODS: We will search PubMed, Web of Science, Cochrane Library, and Chinese biomedical databases from their inceptions to the October 31, 2021, without language restrictions. Two authors will independently carry out searching literature records, scanning titles and abstracts, full texts, collecting data, and assessing risk of bias. Review Manager 5.2 and Stata14.0 software will be used for data analysis. RESULTS: This systematic review will investigate whether MR-HSG has more diagnostic value than hysterosalpingosonography in evaluation of fallopian tubal occlusion of female infertility. CONCLUSION: Our meta-analysis indicated MR-HSG may serve as an alternative for further evaluation of fallopian tubal occlusion of female infertility. SYSTEMATIC REVIEW REGISTRATION: INPLASY2021110050.

Diagnostic accuracy of ultrasound shear wave elastography combined with superb microvascular imaging for breast tumors: A protocol for systematic review and meta-analysis.

BACKGROUND: Shear wave elastography (SWE) is a new ultrasonic elastography technique for evaluating the hardness of living tissue by measuring the propagation velocity of shear wave in tissue, which is characterized by real-time, non-invasive and quantitative. The SWE technique can be used to diagnose the lesions of different tissues and organs, and the quantitative measurement of SWE is considered as more objective information about breast masses. Superb microvascular imaging (SMI) is a new noninvasive Doppler ultrasound imaging method, which can display blood flow information with high spatial resolution and high frame rate, while keeping the minimum low-speed blood flow components. Therefore, SMI can diagnose diseases closely related to angiogenesis at a relatively early stage. However, the results of these studies have been contradictory. The present meta-analysis aimed at determining the accuracy of SWE combined with SMI in the differential diagnosis between benign and malignant breast lesions. METHODS: We will search PubMed, Web of Science, Cochrane Library, and Chinese biomedical databases from their inceptions to the April 18, 2021, without language restrictions. Two authors will independently carry out searching literature records, scanning titles and abstracts, full texts, collecting data, and assessing risk of bias. Review Manager 5.2 and Stata14. 0 software will be used for data analysis. RESULTS: This systematic review will determine the accuracy of shear wave elastography combined with superb microvascular imaging in the differential diagnosis between benign and malignant breast tumors. CONCLUSION: Its findings will provide helpful evidence for the accuracy of shear wave elastography combined with superb microvascular imaging in the differential diagnosis between benign and malignant breast tumors. SYSTEMATIC REVIEW REGISTRATION: INPLASY202150075.