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Vaccine ; 28(18): 3086-94, 2010 Apr 19.
Artigo em Inglês | MEDLINE | ID: mdl-20199764

RESUMO

Fijian infants aged 6 weeks were stratified by ethnicity and randomized to receive 0, 1, 2, or 3 PCV-7 doses with or without the 23-valent pneumococcal polysaccharide vaccine (PPV-23) at 12 months. Strong booster effects for all 7 PCV-7 serotypes were elicited, and for 4/7 serotypes these responses were highest in the single PCV-7 group. There were fourfold rises in GMC for all non-PCV-7 serotypes. By 17 months the PPV-23 group still had significantly higher GMC (each p<0.001) for all serotypes. The PPV-23 was well tolerated and induced excellent responses for all serotypes which were greatest in the single PCV-7 group.


Assuntos
Anticorpos Antibacterianos/sangue , Esquemas de Imunização , Imunização Secundária/métodos , Vacinas Pneumocócicas/efeitos adversos , Vacinas Pneumocócicas/imunologia , Pré-Escolar , Vacina Pneumocócica Conjugada Heptavalente , Humanos , Imunoglobulina G/sangue , Lactente
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