1.
Org Lett
; 14(19): 5082-5, 2012 Oct 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23005340
RESUMO
Intermolecular hydroamination of unactivated alkenes represents a significant synthetic challenge. An efficient Cope-type hydroamination is achieved under mild conditions for reactions of N-alkylhydroxylamines with allylic amines, using hydrogen bonding to achieve increased reactivity and high regioselectivity. This approach provides a number of highly functionalized vicinal diamine motifs as Markovnikov addition products.
Assuntos
Alcenos/química , Aminação , Hidrogênio/química , Ligação de Hidrogênio , Estrutura Molecular , Oxirredução
2.
Synthesis of pyridines and pyrazines using an intramolecular hydroamination-based reaction sequence.
Angew Chem Int Ed Engl
; 48(44): 8325-7, 2009.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19784988