The mortality, modes of infection, diagnostic tests, and treatments of Marburg virus disease: A systematic review.

Background and Aims: Marburg virus (MARV) has regularly affected people since 1967 causing multiple outbreaks. There are presently no authorized therapies for the fatal Marburg virus disease (MVD), which poses an imminent risk to global public health. The MVD has so far claimed the lives of numerous people, with an increased number of cases being seen throughout the African continent. Hence, a review was carried out to analyze the geographical distribution of MVD, mortality, routes of transmission, and diagnostic and treatment modalities. Methods: PubMed, Scopus, Web of Science, Google Scholar, and ProMED servers were used to conduct a systematic search in compliance with the PRISMA guidelines. The results were tabulated and analyzed. Results: A total of 11 studies (7 case reports and 4 case series) were included in the final analysis, and 21 cases of MVD were analyzed. The most frequent symptoms were fever (66.67%), vomiting (57.14%), headache (52.38%), diarrhea (52.38%), and pain (47.62%). The most commonly used diagnostic test was RT-PCR (42.11%). Contact transmission (50%) and zoonotic transmission (37.5%) were the most prevalent routes of transmission. Antibiotics (61.5%) were the first line of treatment. The most common complications were hemorrhage (60%) and coagulopathies (33.3%). The mortality rate was 57.1%. Conclusion: To avoid disastrous consequences, it is essential to reiterate the necessity of early diagnosis and treatment of MVD.

The need for more medical schools in medically underserved regions in Africa.

Africa struggles with the double burden of disease, bearing the highest disease burden in the world and also having the most severe health workforce shortage. Only four countries on the continent meet the WHO-recommended density of 4.45 health workers per 1000 people. This physician shortage has been attributed to a variety of factors including shortfalls in medical education and medical schools' capacities. This commentary aims to reveal the gap and 'underrated' problem of inadequate medical schools and poor utilization of existing ones. Recommended solutions calling for the need for urgent improvement in medical education in Africa are highlighted in the paper.