1.
ACS Med Chem Lett
; 1(2): 59-63, 2010 May 13.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24900177
RESUMO
Hematopoietic prostaglandin D synthase (HPGDS) is primarly expressed in mast cells, antigen-presenting cells, and Th-2 cells. HPGDS converts PGH2 into PGD2, a mediator thought to play a pivotal role in airway allergy and inflammatory processes. In this letter, we report the discovery of an orally potent and selective inhibitor of HPGDS that reduces the antigen-induced response in allergic sheep.